Co-Translational Incorporation of (R)- and (S)-β2-Hydroxyacids In Vivo: Directed Evolution of Efficient Aminoacyl-tRNA Synthetases | Journal of the American Chemical Society https://t.co/n5Tt8F4JDC
An accompanying paper from @AlannaSchepartz and Jamie Cate groups shows how the E. coli ribosome supports the incorporation of the non-α-amino acid monomers https://t.co/JBNGTPbEXO
Chintan's @cpsoni_74 work demonstrating the efficient incorporation of non-α-amino acid backbones into proteins expressed in both E. coli and mammalian cells, just came out! A great collaborative effort from @cgem_cci! https://t.co/lJJklJcArk
Starting 2026 with Quan Pham's paper expanding the chemical toolbox for engineering AAV
- New bioorthogonal labeling, including IEDDA, for efficient macromolecule attachment
- Incorporation of two different chemistries for dual capsid labeling & much more:
https://t.co/ITupX1fsXq
Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by @conor_loynd, @SinghaSoumya, and @SCanarelli! We introduce a new generation of BONCAT tools for versatile characterization of newly synthesized proteins in pathogenic bacteria https://t.co/OcGg6aMVXY
Cool work from @Han_Xiao2016 on site-specific incorporation of an environment-sensitive fluorescent noncanonical amino acid to visualize protein microenvironment changes in living cells
Our work @cgem_cci on co-translational incorporation of a noncanonical monomer into a protein, followed by its triggered post-translational chemical rearrangement, yielding novel backbone modifications. https://t.co/T8T4Fs4BSp
Happy to see this new T7 replicon based orthogonal replication system in E. coli. Congrats to the Diercks and Schultz lab teams at Scripps Research! https://t.co/vhVgLyxuot
I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share!
https://t.co/cyVZpAwJiq
Today in @ScienceMagazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with @SternbergLab.
1/13
https://t.co/ZLHtZm5Gmw
Writing in @J_A_C_S, we report a sugar-derived single-addition monomer that can be added together with other monomers in #ROMP and install functional groups at the chain end of metathesis polymers. #glycotime#polymer#NSFfunded
https://t.co/uezAc9OdZ0