Bhattacharyya Lab

science enthusiasts in Pharmacology @Yale studying molecular mechanisms of cell signaling in cancer and neurodegeneration (

[Bhattacharyya Lab @moitrayee_lab]

Preprint from my lab @YalePharm uncovers the molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling using #singleMolecule #microscopy, #cryoEM, #ephys, #signaling, offering a clear blueprint to target this much sought-after pathway! https://t.co/tpkHpoW14d

[Avner Schlessinger @SchlessingerLab]

New paper from the lab. Using AI-guided modeling and experiments, we identified a hidden allosteric pocket in the cancer kinase PKMYT1. Led by @NHerrington24 in collaboration with @LazarusLab https://t.co/TOVfd0tesd

[Prof. Michael Lin @MichaelLinLab]

For those keeping track of kinases and brain diseases, LRRK2 inhibitor fails to benefit idiopathic Parkinson’s patients. Trial for PD caused by LRRK2 mutations still ongoing. https://t.co/f66bukNSl5

[Yale Pharmacology @YalePharm]

Join us in welcoming our next 2025–2026 Pharmacology Seminar Series speaker, Dr. Aashish Manglik of the University of California, San Francisco. He will be presenting his work at 12 pm on Thursday, April 16th in the Brady Auditorium.

[proteinsociety @ProteinSociety]

March 17 is the deadline for abstract submission for Open Talks (in every session) and Travel Grants (up to 100) for our 40th Anniversary Symposium in Boston, MA. Don't miss it! Abstract fees are $15 for student members and $30, for non-members.
https://t.co/RtXn1NrQeo

[Taekjip Ha @taekjip]

Consider applying for this Gordon conference on single molecule approaches to biology! Suliana Manley is the keynote speaker.

[Bhattacharyya Lab @moitrayee_lab]

@JunLiuLab @YaleMed @YaleMicroPath Congratulations Jun, very cool!

[Mahipal Ganji @mahipal_ganji]

🚨 Postdoc Position Open 🚨

Study protein-DNA interactions w/ cutting-edge single-molecule imaging in our lab!

Exciting projects perfect for ANRF-NPDF apps. Motivated postdoc candidates: Approach us!

Mahipal Ganji
[email protected]
https://t.co/cRiK9rjNoC

[Bhattacharyya Lab @moitrayee_lab]

Super cool work! I can see so many applications!!! Congratulations 🎉

[Abhishek Chatterjee @AChemSynBio]

Starting 2026 with Quan Pham's paper expanding the chemical toolbox for engineering AAV
- New bioorthogonal labeling, including IEDDA, for efficient macromolecule attachment
- Incorporation of two different chemistries for dual capsid labeling & much more:
https://t.co/ITupX1fsXq

[Vijay Sankaran @bloodgenes]

Delighted to have our work on 🧬 resilience to 🩸cancer led by @GauravA_UK & amazing collaborators, including @KharasLab, published in @ScienceMagazine: https://t.co/lZDCy8CSBv 🧵

[Cell @CellCellPress]

In the latest issue! Inhibition of oligomeric BAX by an anti-apoptotic dimer https://t.co/L1mjmfu7nw

[Hồng Minh Triết @atonidascs]

Super excited to share our latest finding on the EGFR activation mechanism. In our paper, we found that cholesterol in the inner leaflets of the plasma membrane is essential for ligand dependent EGFR activation.
https://t.co/vyuJJQihsq

[Bhattacharyya Lab @moitrayee_lab]

This project was led by the very talented Dr. Shailesh Kumar and Harry Jung in my lab, with outstanding collaborative support from what was truly a dream team! Special thanks to Drs. Shyamal Mosalaganti and Yamuna Krishnan for making this fun!

[Bhattacharyya Lab @moitrayee_lab]

Preprint from my lab @YalePharm uncovers the molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling using #singleMolecule #microscopy, #cryoEM, #ephys, #signaling, offering a clear blueprint to target this much sought-after pathway! https://t.co/tpkHpoW14d

[Bhattacharyya Lab @moitrayee_lab]

Our findings have outsized implications for selective targeting of #ChronicPain without adverse effects on trophic signaling OR treatment of #neurodegeneration without eliciting dose-limiting pain. A detailed step-by-step description of this preprint is coming soon!

[Lemmon and Ferguson Labs @LemmonFerguson]

FDA approves 100th small-molecule kinase inhibitor https://t.co/nrDmPmNm8H

[Lemmon and Ferguson Labs @LemmonFerguson]

Please join us on Nov 20th at noon in Brady Auditorium to hear about Moi Bhattacharyya's exciting work.

[Bhattacharyya Lab @moitrayee_lab]

We now provide a molecular framework to uncouple the nociceptive from neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling. This finding has outsized implications for selective targeting of chronic pain and neurodegeneration.

[Rockefeller University @RockefellerUniv]

Researchers in the Vosshall lab have discovered the first evidence of what happens when a female mosquito chooses to mate for the one and only time in her life.

We spoke to @leslievosshall and @LeahHouri about their unexpected findings. See the full Q&A:https://t.co/4NODZOfc9n

[Bewersdorf Lab @bewersdorflab]

Super-resolution single-molecule fluorescence meets quantitative phase contrast! This powerful combo enables ~0.05 nm optical path difference detection, < 20 nm resolution, and continuous live-cell imaging with digital staining, opening new windows into molecular dynamics!🔬

[Giovanni D'Angelo @Gio_Dangel0]

This is a game changer