Michael Kharas MSK

Michael Kharas PhD is a Member in Molecular Pharmacology at the Sloan Kettering Institute. Tweets are my views alone not MSKCC.

[Elvin Wagenblast @Elvin_Wag]

Excited to share our new preprint! ChromE-seq reads 3D chromatin and gene expression in one cell. Across ~400,000 human primary cells, B lineage has the fewest chromatin loops and is most perturbed in trisomy 21, driving the B-cell block in Down syndrome.
https://t.co/Ssehmqjyjc

[Elvin Wagenblast @Elvin_Wag]

🧬 Happy to share our new study in @BloodAdvances! Many inherited cancer predisposition genes only cause disease once a second mutation arrives. We tested that directly, combining CRISPR editing of human primary blood stem cells with xenotransplantation.🧵https://t.co/mPDIjQLQuJ

[Keshari Lab @KeshariLab]

Congrats to @Nancy_T_S for pulling together and leading this great collaborative effort between our lab and @JustinPerryPhD! Here we build more on the concept of metabolic symbiosis… https://t.co/4EF07agQ0H

[Kostas Tzelepis @TzelepisLab]

Today in @NatRevDrugDisc (#NRDD), we proudly present a timely Perspective on the overall druggable landscape of RNA-binding proteins (RBPs), with a strong emphasis on the recent and exciting scientific advances around cell surface RBPs (csRBPs) in disease.

Many congratulations and a big thank you to my absolutely amazing colleague @GaiaTimote98110 for putting this inspiring piece together, as well as to my fantastic collaborators and key experts in the field, @AbdelWahablab, Ryan Flynn, and Benson George for their very important contributions!

We hope that our Perspective will benefit the wider scientific community by providing a clearer understanding of the therapeutic potential of targeting RBPs and csRBPs.
https://t.co/vh2ZgFfWAD

[Michael Kharas MSK @KharasLab]

@Yael_David__ Congrats! Amazing run and the fun is just begun!

[Sara Zaccara @SaraZaccara]

Excited to share our new preprint! 🎉

Using base-editor screens, we reveal how individual residues within the intrinsically disordered region of YTHDF2 control protein interactions, condensate recruitment, and m⁶A-dependent mRNA decay.

https://t.co/kJO8sit1J9

🧵👇

[Kivanc Birsoy @KivancBirsoy]

Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv
https://t.co/JYyu5eAoVu

[Michael Kharas MSK @KharasLab]

@leonard_zon Amazing congratulations!

[Michael Kharas MSK @KharasLab]

@Yael_David__ @BobowskiBritt @drsarahfaulkner @LabMelnick @LabSkoultchi @InLiuOfBulkExps Congrats!!!!

[Manel Esteller @ManelEsteller]

We used single-cell multiomics to trace the MDS-to-AML trajectory upon #HMA treatment and uncovered how #DNA #methylation clones evolve along the way. Featured in @LeukemiaJnl !
#SingleCellGenomics #AML #MDS #CancerBiology
https://t.co/DjldbtHZ3V

[Kentsis Research Group @KentsisResearch]

Read our latest: Recurrent non-canonical proteoforms in acute myeloid leukemia identified by integrative proteogenomics https://t.co/V9b6lAZHP8

[Michael Kharas MSK @KharasLab]

@rosslevinemd @RossLevineLab @MSKCancerCenter Congratulations!! Amazing!

[Harold K Elias 🇮🇳🇺🇸 @hrldelias]

I am thrilled to share that I've received a NHLBI K08 Career Development Award — "The Role of Zbtb1 in Normal and Clonal Hematopoiesis."

As an immigrant physician-scientist, this was once a pipe dream — the kind of career that felt like it belonged to someone else's story.

None of this would have been possible without the people who shaped this path. My mentors, @KharasLab and @DrMvandenBrink. My advisory committee — @AbdelWahablab, Ivan Maillard, Christina Leslie, @RichardKoche, @KivancBirsoy, and @RossLevineLab. @cedunbar80, @dstarczynowski, and @SteidlUli, for their unwavering guidance and support over the years. And above all, to my family, who has stood beside me through every step.

I'm excited for this next chapter and look forward to building an independent research program.

To anyone who feels like they don't belong in this room yet: keep going !

[Michael Kharas MSK @KharasLab]

@KeshariLab Congrats to Briana! We are so proud! Such a great day!

[Keshari Lab @KeshariLab]

Congrats to Briana for defending her PhD, so many amazing directions all coming together! Especially being able to bridge @KeshariLab and @KharasLab. We are looking forward to the things you do next.

[Manel Esteller @ManelEsteller]

Thrilled to deliver tomorrow seminar at the Memorial Sloan Kettering Cancer Center @MSKCancerCenter in #NYC invited by @KharasLab . If you are in the Big Apple, come listen how #epigenetics shapes #cancer

[Michael Kharas MSK @KharasLab]

@KarunaMDPhD @Nature I am honored. So cool. Thank you for including me.

[The Mark Foundation for Cancer Research @TheMarkFdn]

Congratulations to Emerging Leader Award winner @TuomasTammela for being named a 2026 Stephenson Global Scholar!

[Karuna Ganesh @KarunaMDPhD]

Thrilled to share our latest work is out today in @Nature

ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer.

https://t.co/YFOTEapoB8