narf42

Associate Professor for Molecular Evolution @univgroningen
; passionate scientist and insomniac. News, views & random things

[narf42 @narf42]

🥳🥳🥳 Our study on engineering enzymes to break C–F bonds is now out in @angew_chem! Congrats to the brilliant & dedicated Suzanne Jansen for taking this first step toward the future bioremediation of #PFAS & other contaminating organofluorides!
https://t.co/nqHdexP8Rc

[narf42 @narf42]

📢 📢 📢 !!!Come and join us!! 📢 📢 📢
We are looking for a Postdoctoral Researcher with in-depth experience in next- and third-generation sequencing to help us understand the fitness landscapes of complex biomolecules! Please spread the word :)
https://t.co/SgDfiGDkeK

[narf42 @narf42]

Overall, our study presents the first large-scale engineering campaign of FAcDs and introduces an operationally simple selection platform that paves the way toward adapting these enzymes for the sustainable degradation of contaminating organofluorides. (5/5)

[narf42 @narf42]

With #PFAS and other organofluorides wreaking havoc, we set out to engineer natural defluorinases for man-made organofluorides. All credit goes to the amazing @suzanne__jansen, who has outdone herself in this project! (1/5)
https://t.co/qiDxJGWfVs

[narf42 @narf42]

Forcing populations of bacteria expressing tens of thousands of distinct FAcD-variants to utilize various organofluorides as sole carbon source, we elicited a panel of FAcD variants with improved activities and drastically altered substrate profiles. (4/5)

[Maximilian Gantz @MaxGantz_]

So glad to see this out! By giving a strong fluorescence signal to read out NAD(P)H concentration, SAFRAN will greatly extend the range of reactivities comfortably assayable in droplets. This will make droplet microfluidics a much more versatile tool for biocatalyst engineering!

[narf42 @narf42]

Two weeks ago, we had a great group outing, including a city tour through Utrecht, a Mario Kart Wii tournament, and some Rock Band Wii fun! I am truly privileged to work with such a group of talented, dedicated, and smart individuals.

[Francesca Grisoni @fra_grisoni]

🚨Open PhD positions @TUeindhoven & @univgroningen!

Are you intrigued by the potential of ML+directed evolution in drug discovery (@fra_grisoni), peptide catalysis (@robpollice) or biocatalysis (@narf42)?

Do you like interdisciplinary, cutting-edge research?

Then apply!👇

[narf42 @narf42]

📢📢📢The ML-GUIDE team (@fra_grisoni, @robpollice and myself) are looking for 3 PhD students, passionate about combining the directed evolution of diverse biomolecules with deep learning approaches to develop better (bio)catalysts and drugs!
Pls retweet
https://t.co/lh3z4RUTeJ

[Francesca Grisoni @fra_grisoni]

Finally, officially open!

Open #postdoc position in Organic/Medicinal Chemistry for generative #AI in Drug Discovery — join us @molecularML @TUeindhoven 💪🏻

Funded by @ERC_Research
Deadline: Jan 15, 25

More info below👇
https://t.co/a65GM3UX8T

Repost appreciated! 🔃

[Francesca Grisoni @fra_grisoni]

Great news to conclude 2024! I couldn’t think of a better team than the ones and only @narf42 and @robpollice to work on this exciting project. 🚀 Cool times ahead for the collaboration between @TUeindhoven and @univgroningen!

[narf42 @narf42]

Over the past 18 months, we spent A LOT of time planning, discussing, writing, fine-tuning, and WAITING. I had such a blast though and couldn't have wished for a more creative, critical (!), and dedicated team! Thrilled beyond belief that all our efforts paid off!

[narf42 @narf42]

🥳🥳🥳 Early Christmas Present for @fra_grisoni @robpollice and me! @NWOFunding awarded us €2.7 million for our NWO-XL grant "ML-GUIDE – Machine Learning-GUIded Directed Evolution for drug discovery and (bio)catalyst engineering"! Best! Consortium! Ever!
https://t.co/AmMMuEAzv1

[SynBioNL @SynBio_NL]

Porst-doctoral research position at @univgroningen in the group of Danny IncaRNAto on characterizing the role of RNA structural ensemble dynamics in driving cell fate decision.

More info below.
Apply before 2nd Feburary!
https://t.co/u79QFVdgU5
https://t.co/FctQIUYrn3

[narf42 @narf42]

@PStacko @snsf_ch @UZH_en @UZH_Science 🎉 congrats! So well deserved!

[Ivana Drienovska @IvanaDrienovska]

Thrilled to share our latest review on the role of noncanonical amino acids in biocatalysis recently published @ACSChemRev! A big thanks to everyone involved @BartBrouwer7 @francdefel @RoelfesGroup & Emilia and Jan Hendrik (both @biocat_code)!!! 🎊🎊🚀

https://t.co/CYPOc309T4

[Bart Brouwer @BartBrouwer7]

Very excited to share that our review on noncanonical amino acids in biocatalysis is now out @ACSChemRev! Thank you @francdefel, @IvanaDrienovska, Emilia and Jan Hendrik for the great collaboration! @RoelfesGroup @StratinghInst

https://t.co/2BTOqgb886

[narf42 @narf42]

😍🙌🎉 Witnessing a PhD student become an outstanding scientist is the greatest honor for any supervisor. Last week, the amazing @Titi_a93 defended her PhD thesis in style! Listening to her answering challenging questions on cyclic peptides with ease made me beyond proud!