π₯³π₯³π₯³ Our study on engineering enzymes to break CβF bonds is now out in @angew_chem! Congrats to the brilliant & dedicated Suzanne Jansen for taking this first step toward the future bioremediation of #PFAS & other contaminating organofluorides!
https://t.co/nqHdexP8Rc
π’ π’ π’ !!!Come and join us!! π’ π’ π’
We are looking for a Postdoctoral Researcher with in-depth experience in next- and third-generation sequencing to help us understand the fitness landscapes of complex biomolecules! Please spread the word :)
https://t.co/SgDfiGDkeK
Overall, our study presents the first large-scale engineering campaign of FAcDs and introduces an operationally simple selection platform that paves the way toward adapting these enzymes for the sustainable degradation of contaminating organofluorides. (5/5)
With #PFAS and other organofluorides wreaking havoc, we set out to engineer natural defluorinases for man-made organofluorides. All credit goes to the amazing @suzanne__jansen, who has outdone herself in this project! (1/5)
https://t.co/qiDxJGWfVs
Forcing populations of bacteria expressing tens of thousands of distinct FAcD-variants to utilize various organofluorides as sole carbon source, we elicited a panel of FAcD variants with improved activities and drastically altered substrate profiles. (4/5)
So glad to see this out! By giving a strong fluorescence signal to read out NAD(P)H concentration, SAFRAN will greatly extend the range of reactivities comfortably assayable in droplets. This will make droplet microfluidics a much more versatile tool for biocatalyst engineering!
Two weeks ago, we had a great group outing, including a city tour through Utrecht, a Mario Kart Wii tournament, and some Rock Band Wii fun! I am truly privileged to work with such a group of talented, dedicated, and smart individuals.
π¨Open PhD positions @TUeindhoven & @univgroningen!
Are you intrigued by the potential of ML+directed evolution in drug discovery (@fra_grisoni), peptide catalysis (@robpollice) or biocatalysis (@narf42)?
Do you like interdisciplinary, cutting-edge research?
Then apply!π
π’π’π’The ML-GUIDE team (@fra_grisoni, @robpollice and myself) are looking for 3 PhD students, passionate about combining the directed evolution of diverse biomolecules with deep learning approaches to develop better (bio)catalysts and drugs!
Pls retweet
https://t.co/lh3z4RUTeJ
Finally, officially open!
Open #postdoc position in Organic/Medicinal Chemistry for generative #AI in Drug Discovery β join us @molecularML @TUeindhoven πͺπ»
Funded by @ERC_Research
Deadline: Jan 15, 25
More info belowπ
https://t.co/a65GM3UX8T
Repost appreciated! π
Great news to conclude 2024! I couldnβt think of a better team than the ones and only @narf42 and @robpollice to work on this exciting project. π Cool times ahead for the collaboration between @TUeindhoven and @univgroningen!
Over the past 18 months, we spent A LOT of time planning, discussing, writing, fine-tuning, and WAITING. I had such a blast though and couldn't have wished for a more creative, critical (!), and dedicated team! Thrilled beyond belief that all our efforts paid off!
π₯³π₯³π₯³ Early Christmas Present for @fra_grisoni@robpollice and me! @NWOFunding awarded us β¬2.7 million for our NWO-XL grant "ML-GUIDE β Machine Learning-GUIded Directed Evolution for drug discovery and (bio)catalyst engineering"! Best! Consortium! Ever!
https://t.co/AmMMuEAzv1
Porst-doctoral research position at @univgroningen in the group of Danny IncaRNAto on characterizing the role of RNA structural ensemble dynamics in driving cell fate decision.
More info below.
Apply before 2nd Feburary!
https://t.co/u79QFVdgU5
https://t.co/FctQIUYrn3
Thrilled to share our latest review on the role of noncanonical amino acids in biocatalysis recently published @ACSChemRev! A big thanks to everyone involved @BartBrouwer7@francdefel @RoelfesGroup & Emilia and Jan Hendrik (both @biocat_code)!!! πππ
https://t.co/CYPOc309T4
Very excited to share that our review on noncanonical amino acids in biocatalysis is now out @ACSChemRev! Thank you @francdefel, @IvanaDrienovska, Emilia and Jan Hendrik for the great collaboration! @RoelfesGroup @StratinghInst
https://t.co/2BTOqgb886
πππ Witnessing a PhD student become an outstanding scientist is the greatest honor for any supervisor. Last week, the amazing @Titi_a93 defended her PhD thesis in style! Listening to her answering challenging questions on cyclic peptides with ease made me beyond proud!