NSF Center for Genetically Encoded Materials

Re-engineering the ribosome to create a fundamentally new form of chemical matter. An NSF Center for Chemical Innovation. #NSFfunded

🦋:

[NSF Center for Genetically Encoded Materials @cgem_cci]

An exciting #NSFfunded discovery from the Miller Group and C-GEM!

[Miller Group @MillerGroupYale]

Congratulations to the team for further exploring the structure of 3’-(2-Pyridyldithio)-3’-deoxyadenosine via synthetic convergence with an antibiotic, cordycepin, and MicroED. https://t.co/7ad0I1EiZK

[NSF Center for Genetically Encoded Materials @cgem_cci]

✨ New C-GEM preprint
E. coli ribosomes support translation of (R) and (S) β2-hydroxyacids in vitro: a structural and biochemical study

Congrats @chon_majumdar, Alexandra, Noah, Cathy, Katie, Alanna, and Jamie!

https://t.co/8bSp674G1P

#NSFfunded #synbio

[NSF Center for Genetically Encoded Materials @cgem_cci]

Want a digestible summary of our latest paper? Check out this great writeup by @ampepsoc
https://t.co/jtOrJwV7nG

#NSFfunded

[NSF Center for Genetically Encoded Materials @cgem_cci]

✨New from C-GEM in @J_A_C_S:
Peptide Backbone Editing via Post-Translational O to C Acyl Shift https://t.co/gOvYo92pmu

Congrats to @CarlySchissel and coauthors in the @schepartzlab and @GroupFrancis!

#NSFfunded

[NSF Center for Genetically Encoded Materials @cgem_cci]

✨New from C-GEM in @J_A_C_S:
Peptide Backbone Editing via Post-Translational O to C Acyl Shift https://t.co/gOvYo92pmu

Congrats to @CarlySchissel and coauthors in the @schepartzlab and @GroupFrancis!

#NSFfunded

[J. Am. Chem. Soc. @J_A_C_S]

Peptide Backbone Editing via Post-Translational O to C Acyl Shift | Journal of the American Chemical Society @AlannaSchepartz @cgem_cci @czbiohub @arcinstitute @UCBerkeley @UCB_Chemistry https://t.co/z3duCppzzR

[NSF Center for Genetically Encoded Materials @cgem_cci]

✨ New from C-GEM in ACS Central Science:
Thioesters Support Efficient Protein Biosynthesis by the Ribosome
https://t.co/AfomHJIs5X

Congrats to Alexandra & Jacob, along with Isaac, Jess,
@AlexSolivan, Noah, Katie, Alanna, Jamie, and Scott!

#NSFfunded

[Yale Chemistry @YaleChem]

Are you an undergrad graduate (or soon to be) from an underrepresented background seeking research experience to place into a PhD program? A post-bacc experience at Yale, fully funded, can make you a competitive applicant. Learn more and apply by 2/28. https://t.co/LuHPi5vN4F

[NSF Center for Genetically Encoded Materials @cgem_cci]

✨ New from C-GEM on @biorxivpreprint
Monitoring monomer-specific acyl-tRNA levels in cells with PARTI

Congrats Meghan, @CarlySchissel, Izzy, Cameron, and @schepartzlab!
#NSFfunded #RNA
https://t.co/Dd0k1CVq4D

[Nature Protocols @NatureProtocols]

#NewNProt: A direct and quantitative assay to monitor the activity of #aminoacyltRNAsynthetase (aaRS) enzymes by using intact #tRNA LC-MS https://t.co/R8sjhGpYkB @cgem_cci, an @NSF Center for Chemical Innovation #MassSpec

[NSF Center for Genetically Encoded Materials @cgem_cci]

✨ New from C-GEM in @NatureProtocols: https://t.co/oiKRdxJsGA
This intact tRNA acylation assay discriminates acyl from non-acyl-tRNA, identifies rare acyl-tRNA species, and can quantify low-yield reactions.

Congrats Riley, Cameron, Isaac, Sarah, @schepartzlab! #NSFfunded

[Chintan Soni @cpsoni_74]

Thoroughly enjoyed sharing my research on engineering aminoacyl-tRNA synthetases without relying on ribosomal translation, published earlier this year.

Thank you Prof. Ruchi Anand (@ruchianand1975 ) and @Chemistry_IITB for hosting me!

[NSF Center for Genetically Encoded Materials @cgem_cci]

📰 Hot off the press at @NatureComms:

RNA language models predict mutations that improve RNA function
https://t.co/Db59SNiaZo

Congrats to @shulgina_kate and coauthors on a great C-GEM + @igisci collaboration! #NSFfunded #RNA #MachineLearning

[NSF Center for Genetically Encoded Materials @cgem_cci]

✨ The latest from C-GEM on @biorxivpreprint

Structure of an Archaeal Ribosome with a Divergent Active Site
https://t.co/aifikjYRf2

Congrats to Amos, @shulgina_kate, Roan, Jamie, and collaborators on a great story!

#NSFfunded #ribosome

[Alex Solivan @AlexSolivan]

Shoutout Isaac Garcia, current @cgem_cci postbacc in the @schepartzlab!!!

[NSF Center for Genetically Encoded Materials @cgem_cci]

Read about the activity here: https://t.co/i0VWdWlDVb

[NSF Center for Genetically Encoded Materials @cgem_cci]

🍝 It’s #NationalPastaDay! We use pasta to teach how monomer sequence and shape controls the final structure and, therefore, potential functions of a polymer.

Download the at-home guide: https://t.co/JUAUoRBDDr

[NSF Center for Genetically Encoded Materials @cgem_cci]

Congrats, Alex!!

[Alex Solivan @AlexSolivan]

Happy to officially be a PhD candidate now!

Thank you to everyone who has supported me this past year!

@schepartzlab @AlannaSchepartz @cgem_cci @MillerGroupYale @cate_lab @UCB_Chemistry

[NSF Center for Genetically Encoded Materials @cgem_cci]

✨New from C-GEM:
Role of ribosomal protein bS1 in orthogonal mRNA start codon selection

Congrats to @kristina_vboyko, her undergrad mentees Rebecca and Minji, and @cate_lab!

https://t.co/iGyyYDhvnc

[Alex Solivan @AlexSolivan]

Check out our work on introducing thioesters into ribosomal bond formation! It's been a super awesome experience being part of such an interdisciplinary project and super excited to finally see it live on @ChemRxiv!

[NSF Center for Genetically Encoded Materials @cgem_cci]

✨ New C-GEM preprint:
Thioesters support efficient protein biosynthesis by the ribosome
https://t.co/KDBFI9Nqn7

Congrats to the dream team of @anyadkent & @JacobGRobins + collaborators Isaac, Jess, @AlexSolivan, @NoahXHamlish, Katie, @AlannaSchepartz @MillerGroupYale @cate_lab