Many experiments in biology happen one protein at a time, which means synthesizing DNA one gene at a time. This is fine for tens of genes. For thousands, the cost is unsustainable.
Introducing uSort-M: a method to isolate and sequence-verify thousands of genes at low cost
Excited to begin my postdoctoral appointment soon in the laboratory of Prof. David Liu at the Broad Institute!
This is a big pivot from natural product synthesis, but I am eager to contribute everything I can to gene editing and protein design!
Thanks everyone for your support!
@ZondloLab@ChemRxiv Super cool work Neal! Did you guys notice any resin decomp issues during your cross coupling? 110C for 18h is the hottest on-resin reaction I think I’ve seen before
Inspiring day at the @berkeleyMCB Molecular Therapeutics Division retreat at Bakar BioEnginuity Hub! Grateful to our trainees for sharing their research and to keynote Kevin Eggan (CSO at BioMarin) for insights into translating basic science into life-changing therapeutics.
Adding to the growing toolbox of aryl azide syntheses: From @Shangyu_Li on @ChemRxiv, Pd-catalyzed coupling of ArBr/ArOTf with NaN3. This reaction is trickier than it looks: as we show, [LPd-N3]2 dimers form with many L's & the pdt can inhibit Pd(0).
https://t.co/w8Req4nD39
We detail the design & synthesis of metal-ɑ-helix frameworks. If you are just interested in learning how to make #peptides, we have provided a thorough procedure for setting up your first solid phase peptide synthesis (#SPPS)!
Article free until Sept 6! https://t.co/yZBOrQbEY5
I'm excited to share my lab's first preprint! It describes Affinity Map, a highly general method providing proteomic profiles of binding affinity for small molecules, peptides, and antibodies in cell lysate, organ extracts, and live cell surfaces.
https://t.co/EvUtvTp7SN
@KCGOrtiz Most “rules in chemistry” don’t really hold up or could actually end up steering you wrong so don’t get too tied up them. Recognizing patterns and learning how one experiment can teach you what to do in the next is really the secret sauce
Our approach to the total synthesis of chartelline C, out now in JACS. Photochemistry and unique topology gave way to some really interesting reactivity!
https://t.co/GeS8LaxesB
Congrats to MCB postdocs Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab) for being selected as 2025 Jane Coffin Childs Fellows! 🎉👏 @schepartzlab@NogalesLab@RapeLab@heegwangroh
https://t.co/UO8YBjKl5J