Carter Brzezinski

Biocatalysis, Pharmacology, Swimming. @KFBChem Postdoc @WuestLab alumni (‘25) @KenyonCollege swammer & alumni (‘20) he / him / his 🇯🇵

[Carter Brzezinski @sp3intermediate]

Check out @HJLChem and I’s recent report on using VHPO enzymes to prepare oxindoles and spiro-oxindoles! Excited to see this work out and help eliminate the need for hazardous halogenating reagents and harsh oxidants. Go team VHPO!

[Kyle F. Biegasiewicz @KFBChem]

KFB Lab Alert: Our general biocatalytic platform for the oxidative rearrangement of indoles is now online at @ChemRxiv! Congratulations to @HJLChem and @sp3intermediate for leading this work with Sergio, Raina, Ana, Sophie, and John!
https://t.co/7PMBifdyjJ

[Liela (Bayeh) Romero @Liela_Romero]

Check out our latest work on the co-catalytic reductive cross coupling of aryl bromides and alkynes through the merger of ZrH and Pd catalysis: https://t.co/AUe46ibey4

Kudos to the team: Marymoud Erzuah, @raj_abhishekk_ @RebeccaKehner

[Carter Brzezinski @sp3intermediate]

Couldn’t agree more!

[Laszlo Kurti @kurtilaszlo]

Pleased to share our @J_A_C_S paper on de novo pyrrole synthesis using O-vinylhydroxylamines. These reagents are versatile annulation partners for rapid, regioselective access to electron-deficient and highly substituted pyrroles under mild conditions. https://t.co/GbO4UUJsEP

[Garg Lab UCLA @GargLab]

Recently, Ben and Allison published a procedure for the enzymatic saponification of esters containing β-leaving groups in @OrgSynth. Many thanks to Kevin Campos and the team @Merck for checking, and congrats to the authors!
Read it here: https://t.co/HwwqwsSUAN
@uclachem

[Carter Brzezinski @sp3intermediate]

The incorporation of enzymatic reactions in natural product total synthesis in the past few years is so awesome and inspiring - I really feel like this has ramped up recently. Enzymes are great for everyone, not just process chemists!

[Chao Li Lab @LabChao]

Our latest work shows how modern total synthesis can enable therapeutically meaningful discovery, uncovering selective anti-C. difficile activity and toxin-protective effects of structurally complex polyether ionophores. Now available on ChemRxiv: https://t.co/iXiPUvBeja

[Carter Brzezinski @sp3intermediate]

@LabChao Amazing work, love the epoxide hydrolase step!!!

[Carter Brzezinski @sp3intermediate]

@Braden_Keith It’s juicy, but “the absolutely juciest newsbit that swimming has had in quite some time”?

[Hans Renata @hanzyduzit]

https://t.co/PwQdyi02yu

[Taku Mizutani @TM81241003]

Our @J_A_C_S paper is out!
We found a unique PLP enzyme that builds α-hydroxy β-amino acids.

Can’t wait to make more and more strange amino acids with this guy!
https://t.co/H3w5rRa1fu

[Lopchuk Lab @LopchukLab]

Today in ChemRxiv, we report the C-H amination of unactivated alkanes and aldehydes with diazirines via photocatalysis. This method provides our first approach to acyl diaziridines, which are readily converted to amides, hydrazides, acyl hydrazones and heterocycles.

[UChicago Chemistry @UChiChemistry]

A full account of the Rawal group’s total synthesis of (+)-hinckdentine A is now out in JOC.

In pursuit of the “ideal” synthesis, several routes were explored before an indole-based Claisen rearrangement enabled a concise (5 operations) synthesis of the target.

The paper was selected as an ACS Editors’ Choice and is currently free to read: https://t.co/Gzp2tQGx1A

#OrganicChemistry #TotalSynthesis #JOC #ACSEditorsChoice #ChemistryNews #VireshRawal #UChichemistry

[Ritter Lab @ritter_lab]

Nitrate reduction enables Sandmeyer reactions without sweat on your forehead – even on 20 mmol scale!

Check out our detailed protocol in @OrgSynth and join us on the safer side of diazonium chemistry!

Thanks to @MaulideLab for reproducing! 🤝

https://t.co/0mkTLmnbnO

[Kyle F. Biegasiewicz @KFBChem]

KFB Lab Alert: Our latest work on VHPO-mediated cryptic diazo generation to access triazolopyridines is now out @JOC_OL! Congratulations to @ManiksharmaASR for leading this work!
https://t.co/MSgueP4IkM

[Carter Brzezinski @sp3intermediate]

Awesome work Manik!!!

[Kyle F. Biegasiewicz @KFBChem]

KFB Lab Alert: Our latest work using VHPOs for cryptic formation of nitrile oxides to generate isoxazolines is out now @angew_chem! Huge congratulations to @ManiksharmaASR for leading this work from start to finish!
https://t.co/ROkLJdcmUx

[J. Am. Chem. Soc. @J_A_C_S]

Cooperative Aldehyde Chemistry Maps an Orthogonal Lysine Reactivity Landscape | Journal of the American Chemical Society https://t.co/9sMVXv3cDD

[Laszlo Kurti @kurtilaszlo]

Excited to share our ChemRxiv preprint on de novo pyrrole synthesis via an aza-Michael/oxaza-Cope/aromatization cascade from O-vinylhydroxylamines. Congrats to Charlotte, Zach as well as Oleksander and Pavel (@MykhailiukChem) at Enamine (@EnamineLtd)! https://t.co/IWGuDg5Znw

[Kyle F. Biegasiewicz @KFBChem]

KFB Lab Alert: Our first report in bioinspired catalysis is here! Check out our latest report on a Newman-Kwart Rearrangement Enabled by Flavin Photoredox Catalysis @ChemRxiv! Congratulations to @CG_Chem and @ManiksharmaASR for leading this effort!
https://t.co/nUSHEd3LlR

[Total Synthesis @TotalSynthesis]

The #TotalSynthesis of (−)-spiroaspertrione A: A divinylcyclopropane rearrangement approach by Wenbo Huang, Lu Pan, Heng Zhao, Fabian Schneider, and Tanja Gaich at @UniKonstanz in @ScienceMagazine https://t.co/DRgBPwA5E8

[Kyle F. Biegasiewicz @KFBChem]

KFB Lab Alert: Our first efforts in biocatalytic chlorination of aliphatic amines is now online @ACSCatalysis! Huge congratulations to @EJGChem, @sp3intermediate, Sophie, @Logan_Zane97, and John!
https://t.co/9uf3nAk9by

[Carter Brzezinski @sp3intermediate]

@Braden_Keith @kylesockwell Gotcha ok. I live like 20 min from GT and want to take my gf to see a session so if you happen to hear about two tickets for Saturday I’d take you up on it!

[Carter Brzezinski @sp3intermediate]

@Braden_Keith is there no option to buy single-session tickets for NCAAs in ATL??? Is this usually the case??? Would kill to see a session or two but not for $180…

cc @kylesockwell