Zondlo Lab

Chemical biology/bioorganic chemistry and other such shenanigans. Ruthless multidisciplinarians.

[Zondlo Lab @ZondloLab]

Today’s Organic 1 class covered diastereomers, resolution, and asymmetric catalysis. The Chemistry @NobelPrize #chemnobel fit in perfectly. So I ended class with a song. With apologies to @DollyParton: “Proline” sung to Jolene. Congratulations @ListLaboratory @MacMillan_Lab!

[Zondlo Lab @ZondloLab]

Searching TATP brings me to one of my own tweets from a decade ago. Useful to remind myself of things I’ve previously read!

[Zondlo Lab @ZondloLab]

The @nytimes writing about the challenges of exotherms! As a chemist, odd to read about in major media. #TATP https://t.co/6Bj4wnQcKo

[Zondlo Lab @ZondloLab]

Obviously PolyPro is the BEST building material!

[Zondlo Lab @ZondloLab]

The class was also musically balanced, as I earlier noted that anti-aromaticity makes me sing Taylor Swift “Anti-Hero”.

[Zondlo Lab @ZondloLab]

In class today, I described the pictured reaction. “Do I have any AC/DC fans in the class?” <hands raised> “What is the molecule on the right?” <no answer>
“CAUSE I’M T N T - I’M DYNAMITE! T N T!” - me belting it out.

[Zondlo Lab @ZondloLab]

DELAWARE @UDelaware WITH THE BEST BOWL WINNING PERCENTAGE OF ANY TEAM IN COLLEGE FOOTBALL HISTORY!!!!!

[Zondlo Lab @ZondloLab]

Delaware INT! #weregoingbowling

[Zondlo Lab @ZondloLab]

@soncharm @KelleyKga Basically, if they want to take *any* website down (including things that decidedly fall under the umbrella of “academic freedom”), they can claim “non-compliance with accessibility rules” as a basis for cleaning those items from university-hosted web sites.

[Zondlo Lab @ZondloLab]

@soncharm @KelleyKga The problem is also specifically an issue because university administrators are so insistent on avoiding compliance issues. Things are taken down without warning or explanation, REDUCING accessibility to information in the name of “accessibility”.

[Zondlo Lab @ZondloLab]

I had multiple outfit changes during the final.

[Zondlo Lab @ZondloLab]

Final exam bonus points question:

[Zondlo Lab @ZondloLab]

It was a beautiful morning at @UDelaware!

[Zondlo Lab @ZondloLab]

Rilo Kiley is my favorite answer to this question.

[ghost @ghostamanita]

EVERYBODY SAY YOUR FAVORITE FEMALE FRONTED BANDS *WITHOUT* SAYING PARAMORE AND EVANESCENCE CHALLENGE GO!11!!1!!1!

[Zondlo Lab @ZondloLab]

@AlexSolivan One thing we are careful about is making sure the resin is suspended in the glass vial (using a light football stirbar than essentially floats above the bottom of the vial), rather than crushed under a heavier stirbar.

[Zondlo Lab @ZondloLab]

One paper accepted today and also one new manuscript appearing on @ChemRxiv makes for a good day.

[Zondlo Lab @ZondloLab]

@AlexSolivan @ChemRxiv Nothing that was obvious. Yields (versus amount on resin) were in the ballpark of expected, though we didn’t quantify rigorously. We’ve used these conditions before in cross-coupling, and they worked well! https://t.co/xPa6LzfoeM

[Zondlo Lab @ZondloLab]

And a notification that the just-accepted paper has also been chosen to feature of the journal front cover! Details to follow on publication!

[Zondlo Lab @ZondloLab]

On @ChemRxiv, we describe the synthesis of the novel amino acid 2-mercaptophenylalanine (via a copper-mediated cross-coupling reaction with an N-terminal 2-iodo-Phe on solid phase) and its application in NCL as a phenylalanine surrogate. https://t.co/gXqEOdnG1q

[Zondlo Lab @ZondloLab]

First day of 50th grade!
First day of my 25th year at @UDelaware!

[Zondlo Lab @ZondloLab]

Gordon Conference karaoke also reminds me that Gen Z properly loves Joan Jett. And that their parents are decidedly Gen X.

[Zondlo Lab @ZondloLab]

I had my doubts about Gordon Conference karaoke. I was wrong.

Do you wonder what it’s like to see Erick Carreira sing “Country Roads” or Rick Danheiser enthusiastically belt out “Sweet Caroline”? Exactly.

[Zondlo Lab @ZondloLab]

Though it should be noted that Erick seemed particularly enthusiastic about singing multiple songs from Queen.