Nick Ariotti

Group leader. Cell Biologist. Electron microscopist. @IMBatUQ. Views my own. (He/Him)

[Damien Cahill @DamienCahill8]

Devastating, short-sighted and shamefully irresponsible announcement by @UOW management today of 135 proposed sackings, including whole teaching departments such as history. All the while the VC is a partner in a consultancy firm reviewing the university’s operations. @NTEUnion

[Ishan Deshpande @IshanDeshpande]

Thrilled to share our findings on NINJ1 autoinhibition, now online in @Nature. Big thanks to the amazing team @dixitvishva @Melissa_Truong @DrMCJohnson @AlexisRohou and many others. Video by the talented, twitterless Sergei Pourmal (1/3)

[Debnath Ghosal @DebnathGhosal]

Our latest work on DPANN archaea is now published in the ISME Journal (https://t.co/csBW8kWZPV). Using cryoET, we discovered an enormous attachment organelle in the DPANN cell envelope that forms a cytoplasmic bridge between the host and DPANN cells.

[Cell Biology J-Club @cell_club]

Precision in situ cryo-correlative light and electron microscopy of optogenetically-positioned organelles https://t.co/EZt6XbRVuW

[Nick Ariotti @AriottiNick]

Achieving optical transparency in live animals with absorbing molecules | Science https://t.co/Q3LzHgB0pR

[Kaitlyn Abe @kaitlyn_m_abe]

I am thrilled to share that our manuscript on using LEA proteins to prevent air-water interface damage to fragile samples for cryo-EM is offically out!
https://t.co/WOusFe1Ypb

[Jason Zhaoxing Zhang @jasonzxzhang]

Thrilled to share progress on Ras isoform binders! Using AI-driven protein design, I’ve targeted the challenging, highly charged and disordered C-terminus of Ras. These de novo binders exceed antibody specificity and effectively disrupt Ras signaling. https://t.co/uezpEHhm5b

[GeroldLab @GeroldLab]

We are hiring! 2 #postdoc #positions in advanced infection models and in data-driven #virology tba on Sept 4th at https://t.co/vZIf2klgla Join an enthusiastic and international team of virologists @MedUniInnsbruck in beautiful Tyrol. Join the club of those who #lovevirology

[Melanie D. White, also @melaniedwhite.bsky.social @MelanieDWhite]

Thrilled to see our Lifeact-EGFP quail published @JCellBiol after a fantastic and speedy editorial process. This was a great team effort from the whole lab @IMBatUQ but especially @Yanina61831716 with support from @MariseVan2905 & @wang_jianxiong. #Biology

[Institute for Molecular Bioscience @IMBatUQ]

Will it be the next #antibiotic? A lasting treatment for #ChronicPain? A new way to stop #cancer in its tracks or a novel insight into the #genome?

Do your #PhD at IMB and join some of the world's best to see what you will discover.

🔍 Explore now: https://t.co/0gQbz0z4J8

[Oleksiy Kovtun @KovtunOleksiy]

Our mini-review of the recent reports revealing the architecture of the Commander complex is online.
https://t.co/5y3GMAgVGX

[Institute for Molecular Bioscience @IMBatUQ]

Congratulations to our researchers who have been awarded @nhmrc 2024 Investigator Grants to address health challenges.

◾ A/Prof Frederic Gachon (@GachonLab)
◾ Prof Glenn King (@VenomsLab)
◾ Dr Marina Naval Sanchez (@MarinaNaval)
◾ Dr Hana Starobova (@starobova)

[Brett Collins @brettcollins100]

This work was led by outstanding postdocs Kevin Chen, Vikas Tillu, Navin Gopaldass, Sudeshna Chowdhury, and with amazing assistance from Juanfang Ruan at the UNSW Microscopy unit. @KevinCh33957486 @Vikas7896 @CryoRetromer @KovtunOleksiy @AriottiNick @IMBatUQ @UQ_News. 2/n

[Alice Ting @aliceyting]

LYTACs pioneered by @CarolynBertozzi opened the door to degradation of cell surface and extracellular proteins through lysosomal targeting. Here, we introduce genetically-encoded LYTACs, or GELYTACs, which are (1) easier to produce by recombinant expression (LYTACs, antibody conjugates to glycopeptides, are harder to make), (2) amenable to engineering via directed evolution, and (3) possible to secrete from therapeutic cells such as T-cells.

We demonstrate degradation of various soluble targets, including TGFb, IL6R ectodomain, and mCherry with GELYTACs optimized via yeast display directed evolution, added either as recombinant protein or secreted from living T-cells.

Congratulations to lead author @Jony_theChemist, our wonderful collaborators Sean Yamada-Hunter, @LouaiLabanieh and @molecular_elena from the @mackalllab, and great teaming up again with the formidable @CarolynBertozzi.

https://t.co/WVYAadruBP

[Murphy Lab @_Murphy_Lab]

Happy to announce that our efforts to establish elemental mapping for cryo-EM ❄️ by EELS 🌈 are now shared on bioRxiv: https://t.co/hCTHQCyxN4
Congratulations to @zoliviapg and co-authors!

But wait - Can we map elements in 3D?
🧵👇 1/6

[Nick Ariotti @AriottiNick]

@fiona_whelan @IMBatUQ It’s the CLEM bug… we’re all catching it

[@cellphylab.bsky.social @cellphylab]

This work has found a home! https://t.co/qFEOEnUy67 @MonashBDI @EMBLAustralia

[Nick Ariotti @AriottiNick]

'Can we separate hallucinations and the antidepressant effects of psychedelics?' on @lets_experiment https://t.co/6TN7JUXlcP
Fundamental research is important! Greg and Jack are looking to develop new antidepressants from psychedelics.

[Miao Gui @miao_gui]

I’m delighted to share our work @alanbrownhms on the structures of axoneme, one of the largest macromolecular machine in nature! This is really a dream coming true! Now we have an atomic view of the core of cilia skeleton. https://t.co/hd4AjwBJAw