Happy to share that our work on the FDX2-bound core ISC complex is now published in @NatureComms 🎉
https://t.co/gfmRsx2TSd
By the way, we are now also on @bluesky! 🦋 https://t.co/D3AT4QtVjK
🎉 Our latest preprint is now online 👉 https://t.co/b8EYwcZZMx
Congrats to @RalfSteinhilper who determined #cryoEM structures of the ferredoxin 2-bound core iron-sulfur cluster assembly complex under reducing and turnover conditions at 2 Å resolution.
More below! 👇
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Our elemental mapping work, combining cryo-EM and EELS to REEL analysis, is now also published on Nature Methods:
https://t.co/Yf3UGSGSWe
For a highlight “reel”, see here 👇
Happy to announce that our efforts to establish elemental mapping for cryo-EM ❄️ by EELS 🌈 are now shared on bioRxiv: https://t.co/hCTHQCyxN4
Congratulations to @zoliviapg and co-authors!
But wait - Can we map elements in 3D?
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Congrats to @MaxYin_211013 and co-authors! Big thanks to X-ray team: Tristan Wagner, Olivier Lemaire and Mélissa Belhamri @MarineMicrobio; computational team: Gerhard Hummer and José Guadalupe Rosas Jiménez @HummerLab; MS team: Anna Shevchenko @mpicbg for the great collaboration!
How could CO₂ fixation occur in anaerobic and ancient life? Our new preprint sheds light on catalytic mechanism of the key enzyme CODH/ACS in the Wood-Ljungdahl pathway. Watch the summary movie to see how CO₂ is transformed into acetyl-CoA. Read more: https://t.co/pq42aOwLRF
The story doesn’t end there. QM/MM calculations reveal novel features of the catalytic metalloclusters, the C-cluster and A-cluster. The results suggest an electron storage mechanism for the C-cluster, and the configuration of the A-cluster in the ligand-free resting stage.
Happy to see our study on the structure of 46-kDa Streptococcus pneumoniae NOX out in @NatureSMB! Congratulations to the authors @PABLOSANSEGUND3 and @vicsnorr 🥳
Check it out here (open-access) 👉 https://t.co/HlpklHAeYr
Excited to share our preprint: “Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase” in which we obtained a structure of a 46-kDa membrane protein to 2.2 Å resolution without fiducials.
https://t.co/Cu2RxdxyZq
Many thanks to our colleagues @MPIbp and collaborators in the group of Roland Lill @Uni_MR for cooperation on this story and a study of the sulfur transfer intermediates in the frataxin-bound core ISC complex: https://t.co/EdUgKaF9hF
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🎉 Our latest preprint is now online 👉 https://t.co/b8EYwcZZMx
Congrats to @RalfSteinhilper who determined #cryoEM structures of the ferredoxin 2-bound core iron-sulfur cluster assembly complex under reducing and turnover conditions at 2 Å resolution.
More below! 👇
🧵 1/8
Our study clarifies how FDX2 binds to the core ISC complex and confirms that de novo FeS biosynthesis is a highly concerted process. This might have implications for understanding the concentration-dependent effects of frataxin in diseases like Friedreich’s ataxia.
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More research will be needed to reach single-atom sensitivity. In the meantime, we’d be grateful for any feedback and hope you enjoy the read!
Also, if you’d like to join the team: We do have an open post-doc position! ^^ https://t.co/lycMnKUnUr
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Happy to announce that our efforts to establish elemental mapping for cryo-EM ❄️ by EELS 🌈 are now shared on bioRxiv: https://t.co/hCTHQCyxN4
Congratulations to @zoliviapg and co-authors!
But wait - Can we map elements in 3D?
🧵👇 1/6
A big thanks for their contributions, especially to @_Higor_Rosa, as well as Dietmar Riedel, @YuSebyChen, @FilipPetegem, and the always-helpful team from CEOS whose awesome CEFID we have been relying on, as well as @DECTRIS_News whose ELA has been crucial to this project.
🧵 5/6