Hummer Lab

Molecular simulations and computational biophysics @MPIbp

[IBC2 @IBC2_GU]

A multidisciplinary team around @RamBhaskara4 from @IBC2_GU @goetheuni provides fresh insights into the role of intrinsic disorder in large-scale membrane shaping during ER-phagy. @HummerLab @DikicLab @EnableFrankfurt @sfb1177 @SCALE_Uni_FFM

[Di Wu @MiChAeL_900922]

Happy to share our latest study in @Nature revealing how FLVCR1 & FLVCR2 transport choline & ethanolamine, and shedding light on their roles in related rare diseases. Two in One! 🔬 Read more: https://t.co/hDjQDHWIa0 Great teamwork with @SafarianSchara @HummerLab @nguyenln_ 💪

[Sergio Cruz-León @SergioCruzLeon1]

We are excited to announce the publication of high confidence 3D template matching for #cryoET
@HummerLab @Beck_Laboratory @jpkreysing @geissler_katha @s_l_schaefer @pc_hoffmann @MPIbp @cziscience

Paper's link: https://t.co/97wkNFMVhI

See it in action in our short video!

[Max Planck Institute of Biophysics @MPIbp]

Congratulations!!!👏😀

[Beck Laboratory @Beck_Laboratory]

In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).

[Ram Bhaskara @RamBhaskara4]

Our team’s latest research on IDRs in membrane remodeling. #membraneremodeling #ERphagy @HummerLab @DikicLab

[Max Planck Institute of Biophysics @MPIbp]

Heartfelt congrats to our group leader @eugene_kim__ (@EKimlab) on receiving the Heinz Maier-Leibnitz Prize, one of the most important awards for early-career researchers, for her research on genome packaging! #biophysics @dfg_public @maxplanckpress
👉 https://t.co/O6CelvguPY

[Max Planck Institute of Biophysics @MPIbp]

#ATP, the energy currency of cells, is produced by the mitochondrial protein ATP synthase. Our @HummerLab provides new insights into the structural mechanism and energetics of the crucial proton-driven c-ring rotation by atomistic free energy calculations👉https://t.co/P4nFRH1dKr

[Matt Sikora @BioPhysMatt]

a true adventure and privilege to work Danny's team and colleagues (cryoEM, MS, SAXS) @IBCSinica @asibc512 @AcadSinica @khooAS @TzuJingYang @SKCM2_HU @KarenMinfenghsu big MD from @HummerLab @_mischi @SoBuelow enhanced sampling from @Isa_Grothaus @hmi_group and amazing @vidseh

[Hurley Lab @TheHurleyLab]

🚨Now in print!🚨Sankalp Shukla @Sankalp Shukla_ in collaboration with @PIHanson lab and @HummerLab probes the mechanistic and cellular implications of direct membrane binding by the ESCRT and ERES associated Ca2+- sensor ALG- 2 protein. Read it: https://t.co/TcmuQDRNrW @PNASNews

[Max Planck Institute of Biophysics @MPIbp]

Video by S. Rao: All-atom molecular dynamics simulation of the membrane-recruited ATG12-ATG5-ATG16L1-WIPI2 complex loaded with the ATG3-LC3 conjugate.
Congratulations to all authors from @LazarouLab, @TheHurleyLab and @HummerLab on this amazing publication in @ScienceAdvances!

[Max Planck Institute of Biophysics @MPIbp]

S.Rao from our @HummerLab & coworkers resolve mechanism of LC3 delivery to the phagophore membrane, a key step in selective #autophagy, by combining #MDsimulations & experiments. Three-step targeting of ATG12-ATG5-ATG16L1 machinery leads to LC3 lipidation👉https://t.co/9DtGHuFaKP

[Max Planck Institute of Biophysics @MPIbp]

Scientists from the MPI of Molecular Physiology (@mpimoph) and from our Department of Theoretical #Biophysics (@HummerLab) have identifed a region in actin that functions as a “molecular backdoor” for phosphate to exit through!
👉 https://t.co/Yo7rs9AJy8

[Wout Oosterheert @WoutOosterheert]

Very excited that our manuscript is now online @NatureSMB!

https://t.co/jFMeLSr6bW

We show how actin filaments release inorganic phosphate (Pi) through a “molecular backdoor” and demonstrate that the backdoor is distorted in a disease-linked actin variant.

A thread (1/17)

[Hurley Lab @TheHurleyLab]

New preprint! @AutophaZeke’s PI3KC3-C1/RAB1A structure reveals that VPS15 is a GTP-binding pseudokinase that repurposes the kinase fold to regulate a myristoylation, and stabilize a large rotation in the VPS34 lipid kinase to promote membrane binding and PI(3)P synthesis!

[Hurley Lab @TheHurleyLab]

The 2024 Gordon Conference on Autophagy will be held at the beautiful Il Ciocco site in Tuscany Mar. 10-15. If you have a passion for autophagy or just want to learn more, apply now before it gets oversubscribed! https://t.co/YYPxG2rEYr

[Beck Laboratory @Beck_Laboratory]

Detection of various complexes in cryo electron tomograms. Great work by @SergioCruzLeon1 and others now online. @MPIbp #teamtomo #cryoem @ChanZuckerberg

[Max Planck Institute of Biophysics @MPIbp]

The role of CydDC, a potential target for new antibiotics, in the bacterial energy metabolism has remained nebulous for decades. Scientists from our Institute, @ALIFE_VU, @UGent, @UniKent solved the riddle: CydDC is a heme transporter👉https://t.co/qqkC21S97a
#biophysics #cryoEM

[Kei-ichi Okazaki @okapik]

So nice to see Gerhard @HummerLab in Okazaki!

[mito911 @mito911_]

New @biorxivpreprint by Shanlin Rao @HummerLab and co-authors from @TheHurleyLab @LazarouLab for the collaborative work elucidating the mechansisms of LC3 targeting to membranes by the autophagy machinery @ASAP_Research @MichaelJFoxOrg https://t.co/Fahu98BDUo