Structural-functional dissection of arginine sensing by CASTOR1 and its interaction with GATOR2 to regulate mTORC1 signaling, led by Rachel Jansen @TheHurleyLab lab with help from Z-lab postdoc Clement Maghe: https://t.co/Qe7QLldYha
Proud of new work https://t.co/VVD4eyFOlc from the lab by Zhicheng (Chen) Cui @Chen3dem using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ @G__Napolitano, A. Esposito, and A. Ballabio.
Thought you should know, the cryo-EM structure was solved by @MinghaoChen10 and preprinted on Jun. 1, 2023 https://t.co/2btiLItPSo and the cryo-EM coordinates of the same complex were released on Jun. 23, 2023 https://t.co/yCOaHHYAep .
Our new preprint has been published.
This is my first work from the @NodannL . We have elucidated the mechanism of ULK complex formation through in vivo and in vitro experiments based on AlphaFold-predicted structure.
**MEETING ALERT** @BiochemSoc@ASAP_Research 20th Anniversary meeting on #PINK1 mutations in #Parkinsons. Fantastic lineup of speakers; industry and clinical talks and many early-career speaker slots. To register and learn more click: https://t.co/QaVSAlgNpj