Dikic lab

Research group of @iDikic2 at @IBC2_GU.
ubiquitination, autophagy, host-pathogen interactions

[PROXIDRUGS @proxidrugs]

🎙️Honored to enjoy insightful presentations on “RNA-based therapeutics” & “New targets & therapeutic approaches” on day 2 of the 1st Symposium on Advances in Therapeutic Approaches.🙏Thanks to all speakers & participants for their valuable contributions. @BMBF_Bund @HMWK_Hessen

[Dikic lab @DikicLab]

We are making a move ➡️🦋
Follow us there: https://t.co/pJtCoKpR8s

[Dikic lab @DikicLab]

🤩It's out! Check out our latest paper describing an optimised #CRBN that we used for high-throughput drug screening and developing new chemo-proteomic assays. #HTS #TPD @proxidrugs @IBC2_GU @goetheuni

[Cell Chemical Biology @CellChemBiol]

Online! An engineered cereblon optimized for high throughput screening and molecular glue discovery by Henry Bailey, Jonathan Eisert, Fiona Sorrell @Fi_in_Frankfurt, Ivan Dikic @iDikic2 @DikicLab et al at @goetheuni @IBC2_GU @MPIBP @merckgroup https://t.co/sMuAwOMKv5

[Dikic lab @DikicLab]

*See, share, register* for the Frankfurt Conference on Quality Control in Life Processes, 24-27th of March. The speaker's lineup looks amazing already!! 🤩
👉Registration before 1st of December: https://t.co/wK4IpvEhOZ
#FCQC2025 #autophagy #proteostasis #ubiquitin

[SFB 1177 @sfb1177]

Excited to announce the keynote speakers at #FCQC2025!
Aaron Ciechanover from @TechnionLive and @dixitvishva from @genentech

Stay tuned for more updates and don't forget to register! 

https://t.co/SSTnRJoCt1

#autophagy #ubiquitin #TPD #UPS #signaling

[SFB 1177 @sfb1177]

Excited to announce the keynote speakers at #FCQC2025!
Aaron Ciechanover from @TechnionLive and @dixitvishva from @genentech

Stay tuned for more updates and don't forget to register! 

https://t.co/SSTnRJoCt1

#autophagy #ubiquitin #TPD #UPS #signaling

[SFB 1177 @sfb1177]

🔔 Registration deadline approaching!
Don't miss out and secure your spot now!
🔗 https://t.co/SSTnRJoCt1
#FCQC2025

[Dikic lab @DikicLab]

The 2024 #Proxidrugs annual retreat was once again a great chance to meet our colleagues from the consortium. A big shout out to our team members who represented us on stage @acjacomin @GiulioGiulian16 Henry Bailey @mohitasya @shahvarun28
#Cluster4Future @proxidrugs @IBC2_GU

[Dikic lab @DikicLab]

7th year in a row that Ivan is on the @Clarivate Highly Cited Researchers list. Congratulations @iDikic2 , and a big thank you to all the team members, past & current collaborators and colleagues.
#HighlyCited2024 @ClarivateAG @goetheuni @IBC2_GU

[IBC2 @IBC2_GU]

🥳 Proud to see IBC2 Director @iDikic2 on the #HighlyCited2024 list for the 7th year in a row! Congratulations to all @goetheuni colleagues on the list - @StefanieDimmel1, @HummerLab, Florian Greten, Sibylle Loibl & Stefan Offermanns

[Ivan Đikić @iDikic2]

How changes in kinetics of #splicing can lead to proteotoxic cell death & what is the role of #ubiquitination and ER-phagy in this process?

Congrats to Cristian & all collaborators for this fascinating discovery 👏
More info:
https://t.co/ivwFQI2CMd

https://t.co/kjcgfmWOv5

[Dikic lab @DikicLab]

@MPIbp @imbmainz @srcsb @mpi_hlr @KyushuUniv_EN @UCAS1978 @SFB1531 @EnableFrankfurt @dzhk_germany @proxidrugs @ProLOEWE @trr267 @BMBF_Bund @Fraunhofer

[Dikic lab @DikicLab]

Excited to share our latest research published in @ScienceMagazine! Cryptic splicing can lead to proteotoxic stress, but how do cells cope? Our study uncovers the role of ubiquitination and ER-phagy in mitigating the effects of misfolded proteins. https://t.co/fglqtvo9sT

[Dikic lab @DikicLab]

We’re incredibly proud of this work and grateful to the amazing team behind it.🙌@IBC2_GU @goetheuni @CristianPG_mlg @iDikic2 @mixmue
@BrandesLab @JamesAOo7 @StainierLab @shahvarun28 @GiulioGiulian16 @acjacomin @WojtekGalej @ManuelKaulich @IEbersberger @ronaycetin @RayeneBerkane

[João Mello-Vieira @JT_MVieira]

I am very happy to have had the opportunity to present our latest results on targeting #legionella with #protacs. Especially in a session with such renowned scientists. Thanks to Antje Flieger and her team at @rki_de for organising this meeting.

[Dikic lab @DikicLab]

We can’t wait for this conference!😍4 days to talk about quality control mechanisms, the interplay between #autophagy and #ubiquitin and emerging therapeutics utilising the ub system.
Registration Deadline: 1st Dec https://t.co/wK4IpvEhOZ
#FCQC2025 @goetheuni

[Women in Autophagy @WAutophagy]

SAVE DATE: March 24-27, 2025, in Frankfurt. "4th Frankfurt Conference on Quality Control in Life Processes". https://t.co/eZf6aTBGWh

[Cristian Prieto-Garcia @CristianPG_mlg]

Really happy to take part of this amazing manuscript from @crypt_tales and @DiefenbacherL published in @oncogenejournal . USP10 promotes colorectal cancer and stemness. #ubiquitin #cancerResearch 🫶👏🏻

[Alejandro Poveda @alejo_fractal]

I’m thrilled to share that my latest research paper has been published in PNAS! 📄 https://t.co/GeIYrkK7w7

A big thank you to all the co-authors 🙏 @RamBhaskara4 @KateLohachova @iDikic2 @HummerLab.

Thanks to @IBC2_GU @BMLS @EnableFrankfurt @sfb1177 @dfg_public

[Cristian Prieto-Garcia @CristianPG_mlg]

Really happy to contribute with mouse liver cancer models and human cancer data analyses to this amazing Cell paper from @iDikic2 and Herhaus lab. Huge congrats to Lina, Uxia, Ivan and other authors from @jwadeharperlab , @ManciasLab, @DikicLab, etc.👏🏻

https://t.co/9snOiFClqf

[Cell @CellCellPress]

Now online! IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion https://t.co/2xD1MAYHg9

[Dikic lab @DikicLab]

And, of course, a huge thank you to all our collaborators and funders 🫶 @IBC2_GU @EnableFrankfurt @sfb1177

[Dikic lab @DikicLab]

🥳Excited to share our latest research on the role of the autophagy-lysosome system in tumour progression! #cancer #immunotherapy #autophagy @FCI_health @EnableFrankfurt @IBC2_GU @goetheuni https://t.co/KbyqPNhqCR

[Dikic lab @DikicLab]

We identified IRGQ as a key regulator of MHC-I quality control. Its absence enhances CD8+ T cell responses. Reduced IRGQ levels in hepatocellular carcinoma patients and mouse models lead to improved survival by promoting anti-tumour immunity. #CancerResearch #Immunotherapy