Varun Shah

Scientist @Dikiclab @ibc2_gu @proxidrugs | Passion for cancer research and Targeted Protein Degradation

[Varun Shah @shahvarun28]

#2022 TPD research flashback

Like last year, I thought to make a list of papers/reviews which have advanced the targeted protein degradation field in 2022.

#PROTAC #Molecularglues #Targetedproteindegradation

@proxidrugs #AcademicTwitter

[Dikic lab @DikicLab]

The 2024 #Proxidrugs annual retreat was once again a great chance to meet our colleagues from the consortium. A big shout out to our team members who represented us on stage @acjacomin @GiulioGiulian16 Henry Bailey @mohitasya @shahvarun28
#Cluster4Future @proxidrugs @IBC2_GU

[Cristian Prieto-Garcia @CristianPG_mlg]

It is finally out! My first @ScienceMagazine paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor @iDikic2 for all the support and trust ! 🫶. Science https://t.co/P7xasHgVGw

[Ivan Đikić @iDikic2]

#Degradation resistant #tumors - grant funded by German-Israeli foundation for teams from @goetheuni, @HelmholtzMunich & @TechnionLive.

We rented a cottage in the beautiful Swiss Alps for our retreat. Discussing science, walks, peaceful nights with stars, fondue and fun... 😊

[PROXIDRUGS @proxidrugs]

Our #Cluster4Future has been positively evaluated by the jury & will be funded by @BMBF_Bund for a further 3 years!
A fantastic, essential, endorsement of the cluster’s projects - breaking the mold for advancing proximity-inducing drugs in Germany! #Innovation #TPD #TechTransfer

[Ivan Đikić @iDikic2]

Research network #UbiQancer "Functionalising #Ubiquitin system against #cancer" is now supported by @dfg_public. 🫶

Congrats to all members of TRR387 specially to Florian Bassermann @TU_Muenchen .
4 years of science and fun together 😀🙌🥰

More info on: https://t.co/rkwr6QgOLh

[ZhengLab @LabZheng]

Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171. https://t.co/yjUQoEkmN3

[ZhengLab @LabZheng]

Together with labs of @brian_b_liau and Philip Cole and many other collaborators, we are excited to share a new molecular glue story with many surprises. https://t.co/zyoYf2pMNM

[Xinlai's Lab @XinlaiC]

Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN: Cell Reports Physical Science https://t.co/uOMZc2M3pM

[Wojciech Pokrzywa @wojtek_pokrzywa]

Check out our game, DEGRADATOR! 🎮 Designed to popularize and educate on the ubiquitin-proteasome system and PROTACs. Perfect for kids 12+ but not only 😉 Dive into 10 fun levels to explore protein degradation. Available on Google Play and https://t.co/TMiwcfLi9M 🚀

[Harmit S. Malik @HarmitMalik]

That amazing paper you spent years on? That amazing breakthrough you had? Very likely you built this following the work of others (very few exceptions), just as others will build off yours. Science is a continuum. Want to leave a lasting legacy in science? Be generous & be kind.

[Varun Shah @shahvarun28]

@doc_jlmeier Why should have all the fun this year. saving one for next year.

[IBC2 @IBC2_GU]

Christmas times at IBC2: enjoying #mitochondria cookies & listening to Jens Brüning from @CECAD_ in a perspective lecture on how neuronal circuits regulate liver #autophagy & how the smell of food can change mitochondrial morphology. It‘s all about anticipation 🎄😋

[Ivan Đikić @iDikic2]

@SFB1177 focusing on selective #autophagy in health and disease was supported today for the next 4 years by @dfg_public
SFB network is evaluated as:
“#Leuchtturm of autophagy research in Germany at the highest international level”☺️👍
@goetheuni @IBC2_GU @HMWK_Hessen @

[Dikic lab @DikicLab]

After a rich first day of scientific discussions, we take a stroll around Wetzlar, learning more about Goethe and the history of the town.
@iDikic2

[Radek Nowak @RPNowak]

Introducing HiBiT-SpyTag - A Minimal Tag for Covalent Protein Capture and Degrader Development.
Developed at the CPD with @BLZerf6 @LynJonesChemBio and the team! A thread 1/N
https://t.co/jbBm1JmkRo

[Varun Shah @shahvarun28]

@AnshuBhattacha6 @iDikic2 @rukmini2288 @MuenchLab @DikicLab @IBC2_GU Congratulations!

[Luke Simpson @lukemsimpson]

Excited to share our recent paper detailing the development of the affinity-directed phosphatase (#AdPhosphatase) system for targeted protein #dephosphorylation 🎯
.
https://t.co/fo8x6EEnFA
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@gpsapkota @sapkota_mrcppu @sapkota_mrcppu @UoDLifeSciences

[Varun Shah @shahvarun28]

Hope you all find this thread useful and if I have missed anything important feel free to add it here..

[Varun Shah @shahvarun28]

#2022 TPD research flashback

Like last year, I thought to make a list of papers/reviews which have advanced the targeted protein degradation field in 2022.

#PROTAC #Molecularglues #Targetedproteindegradation

@proxidrugs #AcademicTwitter

[Varun Shah @shahvarun28]

22. Reviews not to be missed. 1) Chasing molecular glue degraders: screening approaches, from @CrisMayorRuiz , 2) PROTAC targeted protein degraders: the past is prologue @CraigMCrews
https://t.co/jD77Y7a98H