ZhengLab

Ning Zheng Laboratory at University of Washington

[ZhengLab @LabZheng]

We are still in awe that the "" effect allows this to happen!

[ZhengLab @LabZheng]

Excited to share our lab's latest discovery today in @Nature: "orthosteric molecular glue” (OMG) inhibitors - a new drug design strategy that achieves substrate-dependent potency, i.e., substrate selectivity, with conventional orthosteric inhibitors. https://t.co/U5Y6JBoJql

[ZhengLab @LabZheng]

By selectively inhibiting an enzyme’s activity toward a specific disease-relevant substrate while sparing others, OMG inhibitors could provide a more refined alternative in drug design - enabling the development of treatments that are more effective & better tolerated by patients

[ZhengLab @LabZheng]

Together with Michele Pagano's lab at NYU, we are excited to share a new story on two F-box protein E3 ligases recognizing two distinct & mutually exclusive degrons encrypted in the quaternary structure of the substrate protein https://t.co/UbVCBnJK8g

[ZhengLab @LabZheng]

Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171. https://t.co/yjUQoEkmN3

[ZhengLab @LabZheng]

Together with labs of @brian_b_liau and Philip Cole and many other collaborators, we are excited to share a new molecular glue story with many surprises. https://t.co/zyoYf2pMNM

[ZhengLab @LabZheng]

We now formally define #molecularglue after coining the term for the MoA of #auxin in 2007. https://t.co/VxQou8kPJD

[ZhengLab @LabZheng]

Welcome, two new postdocs Songwen and Mark joined our lab!

[ZhengLab @LabZheng]

Open-state structure and pore gating mechanism of the cardiac sodium channel https://t.co/cp8WYFyTPT

[Huigang Shi @Huigang_Shi]

Finally! Many thanks to my Ph.D. supervisor Dr. Xinzheng Zhang and my labmate Ph.D. candidate Chunling Wu. Low-cooling-rate freezing in biomolecular cryo-electron microscopy for recovery of initial frames https://t.co/JkN0ThLJ76

[ZhengLab @LabZheng]

@JiSunLab @JunminPengLab @AlexmagCryo Congrats!

[Nitzan Shabek @ShabekLab]

We are hiring!!! Please RT: A postdoc position is now open in our growing lab @ShabekLab (@ucdavis California) to study the structure-function of hormone signaling pathway and the ubiquitin system. #structuralbiology #postdocjobs #ubiquitin #Biochemistry #plantbiology

[ZhengLab @LabZheng]

As part of our first entry into the Twitter world, we are happy to present our first preprint!

[bioRxiv @biorxivpreprint]

Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS https://t.co/fkZ9qQ3kvu #bioRxiv