SunLab

The Sun Lab | Structural Biology @ St Jude

[SunLab @JiSunLab]

@Chunyi_Hu1 @shifengxue Congratulations

[St. Jude Research @StJudeResearch]

Scientists led a multi-institute collaboration to create PanNDA, a first-of-its-kind atlas mapping proteomes across six neurodegenerative diseases and more than 10,000 brain proteins. PanNDA can be used as a resource to advance diagnosis and treatment. https://t.co/4ZEu0ze78I

[ZhengLab @LabZheng]

Excited to share our lab's latest discovery today in @Nature: "orthosteric molecular glue” (OMG) inhibitors - a new drug design strategy that achieves substrate-dependent potency, i.e., substrate selectivity, with conventional orthosteric inhibitors. https://t.co/U5Y6JBoJql

[SunLab @JiSunLab]

My lab #NUS is located at the place near the arrow. My daily walk to the lab feels like stepping into the applewood Wardrobe in Narnia.

[SunLab @JiSunLab]

Happy to share our new publication on KCNQ1. In this work, we reveal a cool molecular mechanism that modulates the tissue-specific function of KCNQ1 through its beta subunits, KCNE1/3, which provides different voltage and PIP2 (GPCR) sensitivity for gating https://t.co/KA92pmf1qg

[SunLab @JiSunLab]

@lindsayschwarz Wow 😲 ,🎉

[Rockefeller University @RockefellerUniv]

A new paper from the #MacKinnonLab in @PNASNews finds that while Kv2.1 and EAG1 are from distinct architectural classes of voltage-dependent ion channels, the way the voltage sensors gate their pores is very similar. #RockefellerScience
https://t.co/h7UIKFFGlM

[SunLab @JiSunLab]

@yiweichang @janetiwasa Congratulations, 🎉🎉🎉

[SunLab @JiSunLab]

Congratulations, Hongbo!!!

[St. Jude Research @StJudeResearch]

We’re excited to announce Hongbo Chi, PhD, as the new Chair of the St. Jude Department of Immunology. His leadership will advance our mission to find cures for catastrophic childhood diseases.

[SunLab @JiSunLab]

@abu_remaileh Congratulations, Monther!!!

[St. Jude Research @StJudeResearch]

Our researchers, in collaboration with the Medical College of Wisconsin, have discovered how chemokines and G protein-coupled receptors (GPCRs) selectively bind to control how cells move. https://t.co/nGi6Ou5Bg5

[SunLab @JiSunLab]

Congratulations 🎉, @JunminPengLab

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress

Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: https://t.co/nyUA2qa4G1

Explore this amazing resource here:
https://t.co/Z2bCOKSzs5

[nature @Nature]

Nature research paper: VDAC2 loss elicits tumour destruction and inflammation for cancer therapy

https://t.co/fVxeL9QRTY

[Rui Zhang @RuiZhangWUSTL]

Complex water networks visualized by cryogenic electron microscopy of RNA, done by @RDasLab, @kaiming_zhang, @chiulab
https://t.co/TxSppGxUPG

[Jay Yarbro @YarbroJay]

Excited to share our new paper! We mapped proteomic changes in AD models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more:https://t.co/gmXsIDbUDs
@JunminPengLab @Yanshen73854711 #proteomics #MassSpec #Proteinturnover #Alzheimers

[SunLab @JiSunLab]

Congratulations 🎉 to @LabZheng for the two back-to-back stories on UM171 molecular glue. https://t.co/JTkfBsrz9X;
https://t.co/7EEJrxZMdg

[SunLab @JiSunLab]

Interesting work from @TheHurleyLab

[The Science of Parkinson's @ScienceofPD]

New research from @TheHurleyLab & @ASAP_Research collaborators describes a structural pathway of enzyme activation (determined via cryo-EM analysis) of phosphatidylinositol-3 kinase complexes I (PI3KC3-C1) by VPS15 in autophagy
https://t.co/b5TOyivGR2

[SunLab @JiSunLab]

Congratulations, Chunyi!

[Chunyi Hu Lab @Chunyi_Hu1]

🚀 Thrilled to announce our latest work published in @NatureComms !

NAPTUNE: An ultra-sensitive platform using APE1 to create 5'-phosphorylated DNA, which guides PfAgo for precise nucleic acid & protein detection.
🔗 https://t.co/sE73PT79aa
#Diagnostics #PfAgo #NucleicAcids

[SunLab @JiSunLab]

@SamReckPeterson @PengXu_Sci congratulations, Sam!

[SunLab @JiSunLab]

congratulations, Christoph.

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Congrats to our newest faculty member, Christoph Gorgulla @StJudeResearch, and colleagues @UofT @InSilicoMeds, for work just out @NatureBiotech — using quantum computing to design small molecules that inhibit KRAS. #OpenAccess
https://t.co/h3LtzS8Sb1