Scientists led a multi-institute collaboration to create PanNDA, a first-of-its-kind atlas mapping proteomes across six neurodegenerative diseases and more than 10,000 brain proteins. PanNDA can be used as a resource to advance diagnosis and treatment. https://t.co/4ZEu0ze78I
Excited to share our lab's latest discovery today in @Nature: "orthosteric molecular glue” (OMG) inhibitors - a new drug design strategy that achieves substrate-dependent potency, i.e., substrate selectivity, with conventional orthosteric inhibitors. https://t.co/U5Y6JBoJql
Happy to share our new publication on KCNQ1. In this work, we reveal a cool molecular mechanism that modulates the tissue-specific function of KCNQ1 through its beta subunits, KCNE1/3, which provides different voltage and PIP2 (GPCR) sensitivity for gating https://t.co/KA92pmf1qg
A new paper from the #MacKinnonLab in @PNASNews finds that while Kv2.1 and EAG1 are from distinct architectural classes of voltage-dependent ion channels, the way the voltage sensors gate their pores is very similar. #RockefellerScience
https://t.co/h7UIKFFGlM
We’re excited to announce Hongbo Chi, PhD, as the new Chair of the St. Jude Department of Immunology. His leadership will advance our mission to find cures for catastrophic childhood diseases.
Our researchers, in collaboration with the Medical College of Wisconsin, have discovered how chemokines and G protein-coupled receptors (GPCRs) selectively bind to control how cells move. https://t.co/nGi6Ou5Bg5
Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: https://t.co/nyUA2qa4G1
Explore this amazing resource here:
https://t.co/Z2bCOKSzs5
New research from @TheHurleyLab & @ASAP_Research collaborators describes a structural pathway of enzyme activation (determined via cryo-EM analysis) of phosphatidylinositol-3 kinase complexes I (PI3KC3-C1) by VPS15 in autophagy
https://t.co/b5TOyivGR2
🚀 Thrilled to announce our latest work published in @NatureComms !
NAPTUNE: An ultra-sensitive platform using APE1 to create 5'-phosphorylated DNA, which guides PfAgo for precise nucleic acid & protein detection.
🔗 https://t.co/sE73PT79aa
#Diagnostics#PfAgo#NucleicAcids
Congrats to our newest faculty member, Christoph Gorgulla @StJudeResearch, and colleagues @UofT@InSilicoMeds, for work just out @NatureBiotech — using quantum computing to design small molecules that inhibit KRAS. #OpenAccess
https://t.co/h3LtzS8Sb1