Structural Biology at St. Jude Children's Hospital

Dept. of Structural Biology, St. Jude Children's Research Hospital @StjudeResearch

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Our goal is to understand life and disease at atomic detail. We use #cryoEM, #NMR spectroscopy, #Xray #crystallography, #SingleMolecule spectroscopy, #MassSpectrometry and #computational tools to determine the mechanisms underpinning biological function.

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress

Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: https://t.co/nyUA2qa4G1

Explore this amazing resource here:
https://t.co/Z2bCOKSzs5

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Beautiful work from @JunminPengLab, presenting comprehensive proteomics and phosphoproteomics data from 5 different mouse models for Alzheimer’s disease at different ages, with comparison to human data and many insights, out in @NatureComms
Congrats @YarbroJay & all coauthors!

[Jay Yarbro @YarbroJay]

Excited to share our new paper! We mapped proteomic changes in AD models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more:https://t.co/gmXsIDbUDs
@JunminPengLab @Yanshen73854711 #proteomics #MassSpec #Proteinturnover #Alzheimers

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Congrats to our newest faculty member, Christoph Gorgulla @StJudeResearch, and colleagues @UofT @InSilicoMeds, for work just out @NatureBiotech — using quantum computing to design small molecules that inhibit KRAS. #OpenAccess
https://t.co/h3LtzS8Sb1

[St. Jude Research @StJudeResearch]

As 2024 ends, we’re celebrating key discoveries by St. Jude scientists. In this #ResearchWrapUp, we’re highlighting advances in #MolecularBiology that connect basic science to better health.

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Beautiful work from @kriwacki in @NatureComms!
Eric Gibbs and colleagues study the interactions between nucleolar protein NPM1 and tumor suppressor p14-ARF within condensates, revealing new regulatory mechanisms.
#NMR #SAXS
https://t.co/im6vgL2HcX

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

We have exciting news to share!
Abhay Kotecha (@abhaykot) is joining us as Senior Director of Technologies for Cryo-EM and Cryo-ET. We're thrilled to have him continue his great work in #CryoET, building on his innovation at @thermosciEMSpec.
Welcome to @stjuderesearch, Abhay!

[IRB Barcelona @IRBBarcelona]

📢Don't miss out on our plenary #seminar next week, with Dr. @TanjaMittag, from @StJudeStructBio @StJudeResearch:

🤝Hosted by Dr. @xsalvatella1 (#IRBBarcelona-@icreacommunity).

Register now!👉https://t.co/gPA6e83qNJ

#BarcelonaBiomed

[St. Jude Research @StJudeResearch]

St. Jude names M. Madan Babu, PhD, as Chief Data Scientist. He’ll lead the new Office of Data Science, advancing biomedical research with 115 new roles. His work will help integrate vast datasets and improve patient care. #DataScience #BiomedicalResearch

https://t.co/c5nMfg9oCC

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Congrats to @SchargelRichard, Zuhaib Qayyum, Ajay Singh, Ravi Kalathur – go PTC!!!

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Still hot off the press — @kellogg_liz and colleagues present the first structure of a Fanzor2!
Fanzors are eukaryotic RNA-guided DNA endonucleases. With the available Fanzor1 structures, the new work offers a comprehensive view of the family's evolution
https://t.co/9FuFjm1zzz

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

We end the symposium with closing remarks by Madan Babu @m_madan_babu.

We thank all speakers and session chairs, and hope all participants enjoyed the exciting science and stimulating discussion. We look forward to continuing the conversation at the reception tonight and beyond!

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Final session is on designing function, chaired by @NancyRGough
@Markus Weingarth, @AlissaHummer and Alexandre Zanghellini @biopraxis talk about the latest advances in antibiotic and protein design, and glimpse into the future!#NMR #antibiotics #MachineLearning #AI #proteindesign

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Our @TanjaMittag chairs the upcoming session exploring new approaches, featuring Stephan Rauschenbach @ESIBDLab, @IvetBahar and Francis O'Reilly @FJ_OReilly
#samplepreparation #MassSpectroscopy #ComputationalBiology #proteomics #SystemsBiology

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

We continue to explore #membrane signaling in the next session, chaired by Chia-Hsueh Lee @TheCHLeeLab, featuring talks by Willow Coyote-Maestas @willowcoyote, Nurunisa Akyuz and Justin English @JGEnglishLab
#transporters #channels #mechanosensation #GPCR

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Very excited about the Keynote Lecture by Rod MacKinnon from @RockefellerUniv and HHMI, introduced by former mentee Chia-Hsueh Lee @TheCHLeeLab

The auditorium is jam packed!

#ionchannel #membrane signaling

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Our very own Liz Kellogg @kellogg_liz kicks off the next session, focused on nuclear transactions.
We have 3 outstanding speakers: Yuh Min Chook @yuhminchook, Tatiana Kutateladze @CUAnschutz and Juli Feigon @FeigonLab
#cellnucleus #chromatin #telomerase

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Looking forward to session on decoding protein structure and disorder, chaired by Scott Blanchard @TheBlanchardLab and featuring @TanjaMittag, Edward Lemke @LemkeLab and Kresten @LindorffLarsen
#integrative #IDPs #condensates

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Session on #microbes and #pathogens, with more spectacular #CryoEM and #CryoET!
We have Susan Lea @S_M_Lea and the bacterial flagellum, and Mimi Ho @mimi1inh on an integrated approach to understand the native translation machinery in situ in #malaria parasites.
#molecularmachines

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

We are starting our 3rd Structural and Computational Biology Symposium!

Babis Kalodimos @KalodimosLab opens the event, followed by a session on structural cell biology chaired by Yiorgo Skiniotis, with Abhay Kotecha @AbhayKot and Shyamal Mosalaganti @s_mosalaganti #CryoET

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

@AhmedAdelEzat In person only this year. We might change the format next time

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

All ready for our upcoming symposium here at St. Jude. We have a stellar lineup of speakers and over 250 registered attendees!
Looking forward to two days of exciting science!