Chia-Hsueh Lee

Associate Member, Dept. of Structural Biology, St. Jude Children's Research Hospital @StJudeStructBio

[Chia-Hsueh Lee @TheCHLeeLab]

Our work on human urate transporter is out @cell_res. @YaxinDai
single-handedly drove this project, which revealed the transport and drug mechanism of URAT1. We are grateful for the tremendous support from @StJudeStructBio

https://t.co/XBdLgxsz8G

[St. Jude Research @StJudeResearch]

Investigators have uncovered the full activation mechanism of sweet taste receptors, proteins that detect sugar and sweeteners. Their findings could guide the design of better sugar substitutes. https://t.co/Uprm8rp9fI

[Chia-Hsueh Lee @TheCHLeeLab]

@GenZadChemE Congrats 👏👏👏

[Chia-Hsueh Lee @TheCHLeeLab]

Membrane Transport subgroup @BiophysicalSoc is thrilled to announce the Chris Miller Award—honoring groundbreaking contributions to membrane transport—debuting at the BPS Meeting! Named for Chris Miller, a true pioneer & mentor. Awardees will lecture at our subgroup symposium.

[St. Jude Research @StJudeResearch]

As 2024 ends, we’re celebrating key discoveries by St. Jude scientists. In this #ResearchWrapUp, we’re highlighting advances in #MolecularBiology that connect basic science to better health.

[Chia-Hsueh Lee @TheCHLeeLab]

@danengw @nsmb Very impressive work. Congrats!

[Chia-Hsueh Lee @TheCHLeeLab]

@AlexanderSobol6 @shantigangwar @MariaKarela3 @LauraYen42 @MKCMU Congrats! Sasha and the team

[Chia-Hsueh Lee @TheCHLeeLab]

@HattoriLab @PNASNews Motoyuki, Congrats!

[Chia-Hsueh Lee @TheCHLeeLab]

@MansoorLabOHSU @CryoEM_PNCC @NIH_CommonFund Congrats! Steve.

[Chia-Hsueh Lee @TheCHLeeLab]

@mike_tilapia @DrAnneCarpenter Congrats! Great work.

[Chia-Hsueh Lee @TheCHLeeLab]

@inwardopen @LeaLabTweets @wellcometrust very cool work!

[Chia-Hsueh Lee @TheCHLeeLab]

Congrats!!! @TanjaMittag

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

.@TanjaMittag is named 2025 Biophysical Society Fellow, for her transformative advances on the mechanisms responsible for molecular recognition and phase separation of intrinsically disordered proteins.
https://t.co/rWs4NeoXPp

[Chia-Hsueh Lee @TheCHLeeLab]

Congrats! Scott @TheBlanchardLab

[Taekjip Ha @taekjip]

Scott C. Blanchard to Receive the 2025 Kazuhiko Kinosita Award in Single-Molecule Biophysics https://t.co/bOtA1KtjSw

[Cell Research @cell_res]

Human URAT1 transports urate and is a target for gout treatment.

The Lee lab @stjuderesearch presents 10 cryoEM structures of URAT1 with urate, pyrazinoate, and 3 anti-gout drugs, providing mechanistic insights into urate recognition, transport cycle, and inhibition by drugs.

Read the full article below:
https://t.co/Cc3fwhTL3r

#Gout #CryoEM #Urate #MedicalResearch #DrugDiscovery #StructuralBiology #GoutTreatment

[Boudker Lab @BoudkerLab]

Is it substrate? In our preprint led by @BiaoQiu1, we comprehensively assess EAAT3 substrate recognition properties using DSF, SSM ephys, and cryoEM. The L-Cys bound structure suggests that sodium binding is the final step of gate closure. Read below!

https://t.co/trlTJaIZGB

[Chia-Hsueh Lee @TheCHLeeLab]

@JiSunLab @cell_res @YaxinDai @StJudeStructBio Thank you Ji.

[Chia-Hsueh Lee @TheCHLeeLab]

Our work on human urate transporter is out @cell_res. @YaxinDai
single-handedly drove this project, which revealed the transport and drug mechanism of URAT1. We are grateful for the tremendous support from @StJudeStructBio

https://t.co/XBdLgxsz8G

[Chia-Hsueh Lee @TheCHLeeLab]

@XiaochunLi2 @cell_res @YaxinDai @StJudeStructBio Thank you Xiaochun!

[St. Jude Research @StJudeResearch]

Researchers uncovered ten unique structures of URAT1, providing a deeper understanding on the urate transport mechanism that may offer insights into kidney disease mutations and help guide therapeutic design for gout.

Learn more: https://t.co/RVD6pV1Eaw

[Chia-Hsueh Lee @TheCHLeeLab]

@AlexanderSobol6 @cell_res @YaxinDai @StJudeStructBio Thank you Sasha🙏

[Chia-Hsueh Lee @TheCHLeeLab]

@oxkawaka Or more