Nitzan Shabek

Associate Professor & PI @UCDavis ∙structural biologist⚛︎ ubiquitin system aficionado ✾ signaling & sensing mechanisms in plants🌱🎸dad of 2

[Nitzan Shabek @ShabekLab]

🔥our latest study is now online @NatureComms we found that the salicylic acid catabolic enzymes DMR6/DLO1 are controlled by the ubiquitin system. SA modulates their turnover, revealing a regulatory circuit linking hormone metabolism to immune balance. https://t.co/Xu9zZxgq7G

[UC Riverside CNAS @UCRCNAS]

In Memoriam: Meng Chen, Professor of Botany and Plant Sciences https://t.co/32vStKviGh

#UCRscience #botany #plantsciences #ucr #ucriverside

[Nitzan Shabek @ShabekLab]

Check out our new review @ThePlantCell
A collaborative effort with Yangnan Gu and Shou-Ling Xu, and members of our labs, bringing together practical lessons for designing, executing, and interpreting proximity-labeling proteomics in plants: https://t.co/mlFAEo2Xjs

[ZhengLab @LabZheng]

Two decades after revealing the mechanism of action of auxin, we have now uncovered the molecular mystery of another plant hormone: salicylic acid (SA), the precursor of aspirin that most of us have taken at some point in our lives. We were surprised again https://t.co/yDujLVGxcL

[Nitzan Shabek @ShabekLab]

@LiorTal4 Congratulations!!! Beautiful work

[Nitzan Shabek @ShabekLab]

🔥check out our latest. From signalling to catabolism: terminal tails in plant hormone regulation.
Hormone catabolism is no passive cleanup, but a highly regulated process, exemplified by strigolactone & salicylic acid deactivation & structural plasticity.
https://t.co/GuwqdDGiM5

[Nitzan Shabek @ShabekLab]

🔥check out our latest. From signalling to catabolism: terminal tails in plant hormone regulation.
Hormone catabolism is no passive cleanup, but a highly regulated process, exemplified by strigolactone & salicylic acid deactivation & structural plasticity.
https://t.co/GuwqdDGiM5

[Dr. Neelima Sinha @PlantDevo]

https://t.co/BJElIvZgbi The Dept. of Evolution & Ecology at UC Davis will be hiring this Fall! We're searching broadly, from macro (speciation, comparative genomics, evo-devo) to micro (pop biology, adaptive evolution, evo-eco). Please reach out if you have questions, and apply!

[Nitzan Shabek @ShabekLab]

AI has transformed structure prediction, but its predictive power depends on experimentally determined structural data. Yet plant protein structures account for less than 4% of the PDB, leaving plant-specific folds, conformational changes and transient assemblies underrepresented

[Nitzan Shabek @ShabekLab]

check out our latest review.
Beyond prediction: Why experimental structural biology remains essential in plants.
https://t.co/DohQxe8H6h

[UCDavis News @UCDavisNews]

Plants Walk a Fine Line Between Growth and Defense @ucdavisbiology https://t.co/WeihxjfCaP

[Nitzan Shabek @ShabekLab]

DMR6 undergoes SA-dependent conformational remodeling linked to turnover. We mapped the SCF E3 ligase adaptor interactome during infection, revealing dynamic remodeling, & identified ligase DAF1 using TurboID-DMR6/DLO1. Thanks @ShabekLab members, @Zerbe_Lab, Walley & Dinesh-Kumar

[Nitzan Shabek @ShabekLab]

🔥our latest study is now online @NatureComms we found that the salicylic acid catabolic enzymes DMR6/DLO1 are controlled by the ubiquitin system. SA modulates their turnover, revealing a regulatory circuit linking hormone metabolism to immune balance. https://t.co/Xu9zZxgq7G

[Nitzan Shabek @ShabekLab]

Excited to share our latest review on ubiquitin ligases in plant immunity:
https://t.co/LU3XymC9sq

[Nitzan Shabek @ShabekLab]

@Lumba_lab Thank you, Shelley

[Nitzan Shabek @ShabekLab]

https://t.co/1jnvFSVJVj

[Nitzan Shabek @ShabekLab]

Humbled and honored to receive the UC Davis Distinguished Teaching Award 🏅
Beyond our research mission, education & mentoring are at the core of what we do @ucdavis & I’m grateful for the opportunity to teach such engaged & motivated students https://t.co/1jnvFSVJVj

[Nitzan Shabek @ShabekLab]

Excited to share our new review, now online @AnnualReviews : Structural Insights into Plant Hormone-Sensing Mechanisms
https://t.co/2qDOCkPfrb

[Yasin Dagdas @PlantoPhagy]

Please RT‼️@meo0205 & us are looking for a #postdoc to explore #regeneration & #autophagy across kingdoms of life.Please spread the word & get in touch if interested. https://t.co/k5Vd5WPWXY

[ZhengLab @LabZheng]

Excited to share our lab's latest discovery today in @Nature: "orthosteric molecular glue” (OMG) inhibitors - a new drug design strategy that achieves substrate-dependent potency, i.e., substrate selectivity, with conventional orthosteric inhibitors. https://t.co/U5Y6JBoJql

[Nitzan Shabek @ShabekLab]

Proximity labeling and quantitative proteomics suggest that ASK1/SKP1 assembles condition-specific networks, acting both within SCF E3 #ubiquitin ligases and through noncanonical interactions to coordinate #plant stress adaptation

[Nitzan Shabek @ShabekLab]

Excited to share our latest work to close out 2025: Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation🌱 With the Walley lab, we map how ASK1/SKP1 dynamically rewires protein networks during stress. https://t.co/GoqFnTj87U