#PancreaticCancer Research Lab interested in selective #autophagy, iron, therapeutic resistance, and #proteomics. @DanaFarber, @BrighamWomens, @harvardmed
Excited to share our latest story @NatureComms. Here, we used quantitative proteomics, metabolomics and in vitro/in vivo CRISPR screens to define mechanisms of resistance to DHODHi in PDAC and propose combinatorial approaches with BCL-XL inhibitors:
https://t.co/I5iqDhiSGc
How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer?
A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀
https://t.co/iH8YXDz0X9
During the keynote addresses at #AACRpan24, Eileen M. O’Reilly and Joseph D. Mancias discussed how understanding pancreatic cancer’s strengths can help researchers uncover its weaknesses. Learn more on the #AACRBlog: https://t.co/JtuLTYJxAU @EileenMOReilly@ManciasLab
Joseph D. Mancias discussed "Targeting Autophagy in Pancreatic Cancer" in a Rising Star Keynote Lecture during the AACR Special Conference on Advances in Pancreatic Cancer Research.
#AACRpan24@ManciasLab
WE ARE HIRING! We are looking for a motivated postdoc to work on a fully-funded project studying the role of iron metabolism in drug resistance in pancreatic cancer. 3 weeks left to apply. Please spread the word.
https://t.co/I4WInQ5Oei
https://t.co/2WjWf3aqLV
We are so inspired by patients like Candace and her experience. With a loving and supportive family and the latest treatments at @DanaFarber, Candace is a source of hope for more patients with pancreatic cancer. https://t.co/oXE7vWqNZi
Researchers at @DanaFarber and other institutions recently made important discoveries into the recycling system of pancreatic cancer cells, a promising step toward targeted therapies for one of the most challenging cancers. https://t.co/5B9YXMaHTy
Pancreatic cancer cells operate a recycling program that would be the envy of any municipality — but the only beneficiaries are the cells themselves. https://t.co/gZ0FOHF0tu
A cross-country collaboration between former Damon Runyon-Rachleff Innovators @rushika_perera and @ManciasLab uncovered another way that #PancreaticCancer evades targeted therapies – and a new potential therapeutic target: https://t.co/mh5HOHfUwk
Latest Wolpin-Nowak lab paper on single cell, in situ protein-based characterization of transcriptional subtypes in pancreatic cancer now out in @CR_AACR https://t.co/8IagesbQDg
Robert Hale's determination in @DanaFarber and the Hale Family's incredible generosity help drive @DanaFarber_Hale closer to a cure for pancreatic cancer.
https://t.co/TIJwIueRus