Phren fries 🧠🍟

Neuroleptic-induced deficit syndrome (NIDS), PSSD & ME/CFS from illicit off-label AP. 𝘙𝘦𝘮𝘦𝘮𝘣𝘦𝘳 𝘮𝘦, 𝘣𝘶𝘵 𝘢𝘩, 𝘧𝘰𝘳𝘨𝘦𝘵 𝘮𝘺 𝘧𝘢𝘵𝘦. (Purcell)

[Phren fries 🧠🍟 @asenacide]

@Altostrata I'm sure they have fCOIs as principal investor on intranasal catnip, aka es-cat-amine.

[Phren fries 🧠🍟 @asenacide]

@DBDouble @shvogt @FormerBipolar @drjanaway I'm sorry, bt no level of fancy physiology would solve—or dissolve—the mind-body problem.

[Phren fries 🧠🍟 @asenacide]

@JRBneuropsiq @shvogt It's a perfectly valid Q in a iatrogenic perspective, & it deserves a tentative answer: how more likely is pt P to develop a mis-dxd “SE” instead of an independent psych condition? If this isn't part of clinical reasoning I don't know what is...

[Phren fries 🧠🍟 @asenacide]

@JRBneuropsiq @shvogt @demetriastudy @jill_d35 @SameiHuda @RxISK We can't compare prevalence between a lasting condition & a SE, either treated w/ other meds or hopefully resolved w/ discontinuation: it doesn't make sense, & it's not the motivation behind the OP claim, which is abt mis-dx of new induced harm, not abs prevalence.

[Phren fries 🧠🍟 @asenacide]

@JRBneuropsiq @shvogt It's not misleading, it's the only comparison we have! The real Q is why make the comparison in the first place: harmed pts r almost universally mis-dxd w/ psych disorders instead of iatrogenesis, so Healy's efforts on RxISK r to inform on the higher risks of the latter.

[Phren fries 🧠🍟 @asenacide]

@JRBneuropsiq @shvogt @demetriastudy @jill_d35 @SameiHuda @RxISK Healy's arg is roughly this: psychotic dep has yearly incidence of 0.03/1000, so pretty rare; akathisia & induced agitation is in the double digits for those exposed, so pretty common (data from RCTs), so u could argue for a 100x, even if the populations r different.

[Phren fries 🧠🍟 @asenacide]

@JRBneuropsiq @shvogt Unfortunately we can't easily compare yearly incidence of psychotic dep w/ akathisia & induced agitation, for the latter data is v fragmented in various tx sub-populations, ppl not exposed don't develop it, so incidence depends on inclusion, & heuristics r required. 2/2

[Phren fries 🧠🍟 @asenacide]

@JRBneuropsiq @shvogt My point was re qualitative vs quantitative in general, not specifically akathisia; ofc I know a. is recorded in RCTs, rating scale & all, even tho is always suspect to see a drug-induced disorder also in the placebo arm. 1/n

[Phren fries 🧠🍟 @asenacide]

@JRBneuropsiq @shvogt Right, bt what when the only evidence available is from qualitative studies? Is it the best we have in the EBM pyramid, or should we absolve ourselves w/ Hail Marys & “more research is needed” after 50 yrs? That's pretty ridiculous!

[Phren fries 🧠🍟 @asenacide]

@shvogt @jill_d35 @demetriastudy @SameiHuda @JRBneuropsiq @RxISK Jääskeläinen et al. 2017 report 0.21–6.4/100k annual incidence for psychotic dep; no study on akathisia incidence, bt is almost universal w/ APs in healthy volunteers, v common SE for users, + the common “jitteriness” from ADs, & the withdrawal syndromes.

He's not really wrong.

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@JRBneuropsiq @shvogt Yes, it's rhetorical against the backdrop of no scientific research, thou akathisia is much more common & misdiagnosed than commonly thought, w/ nums in the double digits for APs, + withdrawal a. from APs, BZDs, & agitation from ADs. Not crumbs.

[Phren fries 🧠🍟 @asenacide]

@DBDouble @DianeOLeary @drjanaway Ofc Kant was quite wrong abt the impossibility of a non-teleological account of biology, for another Newton did come, namely Charles Darwin; still, his finitism abt synthetic a priori & his narrower metaphysical re-foundation (not followed by analytic phils) r of great value.

[Phren fries 🧠🍟 @asenacide]

@JRBneuropsiq @shvogt Hate when X doesn't show the header for links. ↑ is this:

[Phren fries 🧠🍟 @asenacide]

@JRBneuropsiq @shvogt Numbers r being used rhetorically all the time in the mainstream, & mindless statistics r part of the rhetoric. Also, the system isn't fair: no one has reported my weeks of suicidal akathisia beside me, it wasn't even recognized by a dozen of psychs. 🤦

https://t.co/CZsfR0uwv3

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@DianeOLeary @drjanaway @DBDouble His legacy includes panpsychism, logical positivism & post-modernism, for he's a philosopher's philosopher, a great writer, not someone w/ easily digestible bullet point set of args. Also, Hegel taught us historical concepts change, so atemporal appeal to Kant is misguided. 8/8

[Phren fries 🧠🍟 @asenacide]

@DianeOLeary @drjanaway @DBDouble He's also a finitist abt knowledge & its boundaries, extremely anthropocentric, a fictionalist abt many concepts, a constructivist abt others, & he's mostly interested in assuring a place for human free will in a borderline-scientistic Newtonian worldview. 7/n