Arthur Etchells

Love learning, building and hard challenges. Grew an eCommerce AI company from 0 to 8-figure ARR. Building what's next.

[Arthur Etchells @asketch]

i've heard parents talk about there being a last time they hold their kids, feed them their supper or change a diaper.

it strikes me that there is a last time most of us use a terminal directly.

[Arthur Etchells @asketch]

one might say this is my most load-bearing alias
```
alias yolo='claude --dangerously-skip-permissions --remote-control'
```

[Arthur Etchells @asketch]

TIL espresso increases cholesterol, pour over does not

[Derek Thompson @DKThomp]

In 2019, there were about 150,000 people working in autism therapy.

Six years later, there were 654,000—more than the number of people who work in mining and logging, or telecommunications, or at the US Postal Service.

[Arthur Etchells @asketch]

@mitchellh I reached the same realization before completing my PPL. Sure I can get this piece of paper that says I’m a pilot, but to feel good about flying loved ones means several hundred more hours and several dozen hours a year (at least) to stay at the top of my game.

[Arthur Etchells @asketch]

@garybernhardt I believe Cursor mirrors (or did at one point) your codebase to turbopuffer. Their head of product mentioned a 1% ab win for this approach in a talk. I suspect the silent part is it’s not about better results, but rather token efficiency.

[Andrew Ng @AndrewYNg]

The new White House policy requiring green card applicants to apply from outside the US is a capricious attack on legal immigration. It will hurt families, leave us with fewer doctors, teachers and scientists, and hurt American competitiveness in AI.

[Avi Roy @agingroy]

Eli Lilly released retatrutide Phase 3 data yesterday. 28% weight loss in 80 weeks. The most powerful obesity drug that’s ever been tested.

And today the cancer signal drops.

12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%). Breast cancer: 43% cut. Colon cancer five-year mortality in a separate study: 15.5% vs 37.1%.

Cancer joins a list that already includes heart disease (SELECT, 20% MACE reduction), kidney failure (FLOW, 24% slower decline), sleep apnea (SURMOUNT-OSA, FDA-approved), addiction (BMJ, 600K veterans, 18-25% reduction across substances), and liver disease (86% fat clearance).

Tumors express GLP-1 receptors. Activate them and NF-kB drops, apoptosis rises. The drug isn’t just shrinking fat. It’s talking directly to the cancer.

One drug class. Designed for blood sugar. The biology keeps finding uses the designers didn’t predict.

[Arthur Etchells @asketch]

They say the fantastic future of our childhood dreams never came, but I'm tickled with joy that Claude can take the wheel to request replacements for stolen Amazon packages!

[David Ferris @d4ferris]

startup gtm tier list, iykyk

[Arthur Etchells @asketch]

It will never not be crazy to me that the FDA approves medicine but the DEA has a separate role where they dictate allowable production levels for medicine.

[Arthur Etchells @asketch]

@Sirupsen @ArfurRock !!

[Arthur Etchells @asketch]

@adityaag love this. learnings are logarithmic over time. jump after 16 months and you miss out on deeper insights on decisions, whether organizational, product or technical, that only reveal themselves over a span of years.

[Hurley @Johnsjawn]

Or go to the Presidio, jump in the ocean, get a coffee at The Mill, watch sunset at Twin Peaks, ride a bike anywhere, see live music, eat a burrito, take a grass nap in GG Park, have beer at The Page, watch the Bay Bridge lights, wander Chinatown, wander Ferry building, run across GG Bridge, walk Fort Funston, eat the best meal of your life with friends…drive any direction for 2hrs. And be deeply grateful for the heavenscape you live in.

[Arthur Etchells @asketch]

@OckhamsRazor4 @FiSurgi Data? Physician-reported burnout has dropped every year for the last four years. Residency practices have never been healthier. Physicians actually report a lower level of regretted career choice than other high-investment careers. What other opportunities?

[Keith Humphreys @KeithNHumphreys]

Very important lesson for Blue Cities here: Every change Lurie has made has been opposed by screaming, bullying activists -- ignoring them has been the path to policy success and extremely high popularity. @skaushik100
https://t.co/sWctBukXM8

[Jean Twenge (author of 10 RULES, GENERATIONS) @jean_twenge]

Reading scores, 3rd graders to 8th graders, 2015 to 2025. This is a national tragedy.

[Sergey Nazarov @sergeynazarovx]

We used to go to a special website, ask strangers for help with programming, and get humiliated in return

[Shoshana Weissmann, Sloth Committee Chair 🦥 @senatorshoshana]

I am down one hell of a rabbit hole

Only like **70** years ago, pharmacists didn't want patients to know the NAME OF THE DRUG they were prescribed so the pharmacist didn't have to explain anything to them.

But it wasn't exactly their fault? Check out the 1952 APA code of "ethics":

"The pharmacist does not discuss the therapeutic effects or composition of a prescription with a patient. When such questions are asked, he suggests that the qualified practitioner is the proper person with whom such matters should be discussed."