Presented at #ASCO26:
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq
@ASCO
new collab from @paradigm and @OpenAI:
evmbench is a benchmark and agent harness for exploiting smart contract bugs
a few months ago, the best models found <20% of critical, fund-draining @Code4rena bugs in our benchmark. today they find > 70%
Our new discovery that bacteria utilize extracellular vesicles to deliver RNAs into fungi substantially broadens the paradigm of Cross-Kingdom RNA communication! Big congrats to @J_NinoSanchez, @HuaitongW and all! Thanks for your hard work! https://t.co/7OAMaItcxa
New L1s succeed by exploiting the dogma of incumbents
Ethereum succeeded by exploiting Bitcoin's resistance to programmability
Solana succeeded by exploiting Ethereum's devotion to home stakers
Hyperliquid is succeeding by exploiting Solana's unwillingness to specialize
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Today's decision markets can only evaluate a single proposal for each decision.
This doesn't scale.
Introducing Quantum Markets: a capital efficient mechanism for scaling futarchy.
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#UCRiverside professors Mary Droser & Hailing Jin were elected to @theNASciences, the highest-profile scientific organization in the country! ✨ Read more ⬇️ #ucr@UCRCNAS https://t.co/ddUfUvrk8d
Alpin is remarkably sophisticated in his understanding of protocols, businesses, and investing. No surprise he's quietly built himself an impressive portfolio and strong founder referenceability. Joining @paradigm is the perfect next step
I’m thrilled to announce that I’m joining @paradigm as an Investment and Research Partner to help @matthuang, @alanapalmedo, and the rest of the team build the best crypto-native investment firm.
Full post in thread!
What if we could universally recombine, insert, delete, or invert any two pieces of DNA?
In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
Excited to share our new work—Plant mRNAs,in addition to small RNAs, move into a fungal pathogen via #Extracellular Vesicles to reduce infection. Big thanks to collaborators @ceiabreu &Paul Birch and great job @shumeiwang5 & team! https://t.co/ZbSqpH9Rgt