In June of 1944, Sgt. James Devine & Pvt. Roland Bonnell, a couple Sappers from an engineer unit, comfort a young French girl and her puppy at Colleville-sur-Mer. 🪖
A new shot literally regrows knee cartilage.
Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).
The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.
In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.
This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.
The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.
Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.
Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.
[Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]
@katrionaos hey Kat, would you consider doing an ADHD test, there's plenty online, I reckon there's a good chance you have it, I was diagnosed at 28 ,46 now....
Being in your early 40s is weird, man. People around your age are in every stage of life. You have people who are grandparents. You have people who have newborns. You have people dating 25-year-olds. You have people celebrating their 20th wedding anniversary. Some of them look 60, and some of them look 30. All the bases are covered when you are in your early 40s.
26-min edition of Eddie Hobbs 'Counterpoint' now available on Youtube, examining the Alexander Coughlan death and investigation, and contrasting it with the death of Yves Sakila.
Gript Media Fatima Gunning is the only journalist to report that the accused in Alex Coughlan prosecution are "of a Muslim and immigrant background".
Alex Coughlan has been mentioned once, and once only in the Dail or Seanad, by Senator Sharon Keogan.
Something has broken in our mainstream media and body politic.
https://t.co/KzuIKSJRay
Remember the Loughgall martyrs
🇮🇪🏴🕊️
On May 8 1987, East Tyrone Brigade PIRA volunteers - Óglaigh Jim Lynagh, Declan Arthurs, Séamus Donnelly, Tony Gormley, Eugene Kelly, Paddy Kelly, Pádraig McKearney & Gerard O'Callaghan, & a civilian Anthony Hughes, were murdered by the SAS.
The moment the Irish Defence Forces were announced as winners in the Bradley category in the 2026 Sullivan Cup.
The Irish Defence Forces own zero Bradley tanks and trained up on these tanks for this competition.
Fair play.
Inspiring! Young Irish patriot speaks boldly for the unborn — says Generation Z is rediscovering Catholic faith and rejecting abortion. What’s your opinion?
☘️ Join & Petition Link: https://t.co/7rhjHXIBLg