Austin Hachey, PhD

Chemical biologist - medicinal chemistry, CYP450s, precious metals, infectious disease, and cancer biology.

[Shenvi Lab @Shenvi_Lab]

Happy to share this total synthesis: not the end, but only the beginning.
https://t.co/FnVqdkDDfS

[Austin Hachey, PhD @austinchachey]

@Cammie_Lesser Wonderful work! Congratulations Cammie, Jason, Coral, et al!

[Austin Hachey, PhD @austinchachey]

This guy right here! It’s been an honor to graduate (back to back) with you - one of the hardest working scientists I’ve ever met, and one of the nicest people around. Wouldn’t have wanted to go through grad school with anybody else! Congrats buddy!!!

[Austin Hachey, PhD @austinchachey]

@GlazerChemLab @meghan_kriger @HavrylyukDmytro The lab (what little I can see of it anyway) looks beautiful!!!

[Mikey Kwon @kwon_mikey]

The C-arylation paper is finally out! Conducting this research was a real herculean task for our team, and I’m very proud to have been part of some of the most hardworking and teammates. I hope you all enjoy this paper because this is some cool chemistry😎
https://t.co/VBnhvMFDJy

[Austin Hachey, PhD @austinchachey]

@That_Chemist For a non-copout answer I might say MeLi, it has it all. Hard, basic, nucleophilic, minimal steric hindrance…

[Austin Hachey, PhD @austinchachey]

@That_Chemist Something very fluorinated… FOOF, ClF3?

[Austin Hachey, PhD @austinchachey]

I’m beyond excited to share with you all the central project from my PhD. We report an extremely potent (0.2 nM!) and selective (19,900-fold!) inhibitor for CYP1B1 and study its interaction with the protein through biochemical and computational techniques. I hope you enjoy!

[GlazerLab @GlazerChemLab]

Wow, @austinchachey's latest paper is out!!! This fantastic work showed how he changed geometric features and functional groups for a HUGE increase in selectivity for our target CYP! Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach https://t.co/zUUs7asLLb

[Raphael Ryan, PhD @RaphaelRyan9]

Old Ru(II) complexes new tricks! Here we report our study on Ru(II) complexes with expanded chelate rings for photoactivated chemotherapy. Work done in the @GlazerChemLab and Selegue lab @ukychem. Thank you @austinchachey @RJMitchell1219 for your help
https://t.co/K8vzYcfNPK

[Austin Hachey, PhD @austinchachey]

Oh. This is bad.

[Austin Hachey, PhD @austinchachey]

Seconding this, Brian’s mentoring was so influential to my development as a scientist. You will not be disappointed!

[Austin Hachey, PhD @austinchachey]

Take a minute to check out this excellent new study from my old friend @dan_wise1 and his colleagues reporting a mild, ozone-free photochemical cleavage of alkenes to produce carbonyls. Great job, all!

https://t.co/4xhm69TjYp

[Austin Hachey, PhD @austinchachey]

@roby_bhatt This is fascinating. My partner tested + by PCR Dec ‘21. I took PCR tests for a week afterwards, all -. Neither of us were symptomatic. She was re-exposed 1.5 wks ago and we have continued to test - by antigen. I figured I had to have abs. I would love to see our serology data 😂

[Samantha Firth @SamanthaJFirth]

New metal complexes rainbow for #PrideMonth

[Austin Hachey, PhD @austinchachey]

This is one of my favorite papers in JACS in recent history, the experiment design is innovative and elegant. Could be easily adapted for folks interested in designing new photodynamic therapeutics.

[The Innovation Materials @Innov_Materials]

JACS online:

Reinterpreting the Fate of #Iridium(III) #Photocatalysts─Screening a Combinatorial Library to Explore #Light-Driven #Side-#Reactions

@J_A_C_S @isciverse @CHNSci @Fibre_Lord
@paul_s_francis @dhayne39 @DeakinIfm
@DeakinSEBE #Chemistry

https://t.co/fAvfvo5CTb

[GlazerLab @GlazerChemLab]

Congratulations to Dr. Dmytro Havrylyuk @HavrylyukDmytro, who was just awarded an Institutional American Cancer Society pilot award to target CYPs for potential cancer treatments! Way to go Dima, and many thanks to @UKMarkey and @AmericanCancer! @ResearchKY @ukychem

[Austin Hachey, PhD @austinchachey]

@roby_bhatt @AlexJaraCarta @kyraltaylor @chienlab I took biochem II with Dr. Chien! First prof. I had in college that lectured on a topic as it was being reported in real time - CRISPR! Pretty incredible experience in retrospect.

[Austin Hachey, PhD @austinchachey]

I don’t think a series of papers has had me this astounded, ever. It makes me want to buy a small UV setup and just start seeing what’s possible.

[Austin Hachey, PhD @austinchachey]

@RJMitchell1219 @DeRoucheyLab Biorender has yet to let me down. They keep stepping up their game!

[Austin Hachey, PhD @austinchachey]

@nippleointment This sounds ingenious as I 1) rarely use my n-BuLi and 2) regularly see 70% humidity in the lab. As an aside I didn’t connect the dots that you’re milkshake until I followed you here (we cross paths on reddit once in a while in the chempros sr)

[Austin Hachey, PhD @austinchachey]

I’ve always thought parafilm would be great to have around the house, except that it’s expensive — and that I would be ashamed to explain what it is, and what it was doing wrapped around the leftovers, to my significant other…