FX MVS

CNS, PNS and macrophage lover.
Interested in (pediatric) neurophysiology, epilepsy and immunology.

[FX MVS @BadFX75]

@eric_kabrams @ImmunoFever @claudeai Same problem for me and not possible to DM you. Thanks

[FX MVS @BadFX75]

@univ_paris_cite @Inserm @HopRobertDebre

[FX MVS @BadFX75]

In our review out in @MyeloidC14405, we discuss that neuromyeloid effects depend on tissue, cell identity, receptor subtype and signal dynamics. The field needs standardized reporting, stronger causal evidence and better translation to human biology. https://t.co/z4wAEBZWOG #ANS

[FX MVS @BadFX75]

@GrablyR Oui ce matin même style que les messages exposés par d’autres

[FX MVS @BadFX75]

@RakutenFrance #RakutenRésolution éliminer toute la poussière de mon intérieur 😎

[Rakuten France @RakutenFrance]

Nouvelle année, nouvelles résolutions ! 🎉

Voici notre concours spécial résolutions 2026 :
1 semaine = 1 super cadeau à gagner !🎁

Résolution n°1 : Prendre soin de son intérieur :
Tentez de remporter un Aspirateur balai Dyson V12! ✨

Pour participer :
- Like et retweete ce post
- Suis @RakutenFrance
- Avec le #RakutenRésolutions, dis-nous ta résolution pour 2026 !

TAS le 8/01🍀

En ce moment, pour votre intérieur, profitez de 15€ offerts dès 119€ d’achat et 30€ offerts dès 299€ d’achat ! 👇
https://t.co/rJMF9mcivk

[FX MVS @BadFX75]

@Fnac Je tente ma chance / participe 🤞🤞

[Fnac @Fnac]

#JeuConcours 🎉 Vous avez besoin d'étendre votre capacité de stockage + profiter de sauvegardes rapides ? ✨ Tentez de remporter 1 Disque SSD Portable Lexar® SL300 1 To !

🎁 Pour participer :
🔁+ 💬 + Follow
📅 TAS 29/12 - 1 gagnant

Joyeux Noël 🎄 !
👉 https://t.co/YWrjqpLJiI

[FX MVS @BadFX75]

@JiwoonPark_ Very impressive and interesting work, congratulations! Do you have any data on the spleen?

[FX MVS @BadFX75]

@CanaudLab @morin_gbrl @ejhg_journal Bravo 👏

[FX MVS @BadFX75]

@CanaudLab @morin_gbrl @alexandre Congratulations Guillaume & the team!

[Iannacone Lab @iannaconelab]

💡Exciting news! Our latest study, in collaboration with Prof. Mirela Kuka’s lab, is out now—uncovering how T cell–derived IFN-γ can suppress T follicular helper (TFH) cells and limit antibody responses. 🚀🧵(1/10) https://t.co/OA0TCnmF7R

🔬Approach: We used a subcutaneous LCMV infection model, tracking virus-specific CD4⁺ T cells. Surprisingly, we found two T-bet⁺ subsets—one producing granzyme B (GzmB) and another expressing Tcf-1, the latter being a TFHprecursor. (2/10)

🌟Key Finding: IFN-γ from T cells drives the TH1 fate and blocks TFHmaturation. When we blocked IFN-γ early, Tcf-1⁺ “precursor” cells fully developed into TFH, boosting germinal center B cells and antibody responses. (3/10)

📊Mechanism: Rather than acting solely via an “autocrine loop,” IFN-γ shapes the microenvironment by acting on other immune cells—likely dendritic cells—thereby steering CD4⁺ T cells toward a TH1-dominant response at the expense of TFH. (4/10)

📌Infections & Vaccines: We also tested other settings—like systemic infections or even MPLA-based immunizations—and consistently observed that reducing IFN-γ can enhance TFH and humoral immunity. Timing is critical for optimal effect. (5/10)

🧬Broader Impact: Our data help explain why some infections trigger robust TH1activity but limited antibody responses, and highlight how precisely timed IFN-γ modulation could improve immunization strategies. (6/10)

🔑Clinical Relevance: In severe or chronic viral infections, TH1-skewed responses can sometimes block high-affinity antibody production. Targeted IFN-γ blockade might tip the balance toward TFH, aiding pathogen clearance or vaccine success. (7/10)

💡Mechanistic Insights: By tuning IFN-γ signals, we can reprogram local lymph nodes and “unlock” TFH potential. This points toward new avenues to combine T cell and B cell–focused therapies for more effective vaccines. (8/10)

👏Huge congratulations to Mirela Kuka, Eleonora Sala, Maria Nelli and all contributors who co-led the study! (9/10)

📖Dive deeper into our research and its implications for antiviral defense and vaccines. We look forward to your thoughts and questions!
Full paper here: https://t.co/OA0TCnmF7R
@SanRaffaeleMI @MyUniSR @ERC_Research @AIRC_it @EMBO @ArmeniseHarvard
(10/10) 💬📚

[FX MVS @BadFX75]

I am also grateful to the three reviewers for their very constructive -and challenging evaluation, and the Editor 3/

[FX MVS @BadFX75]

Very proud to see my work published in Immunity @ImmunityCP It has been a long journey but very enriching on a personal level. 1/

[Immunity @ImmunityCP]

Online now: Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors https://t.co/OOqkPMHcyE

[FX MVS @BadFX75]

I am grateful to all the collaborators from @G_R_Research @CIML_Immunology @criu1149 @SfrNecker @InstitutImagine @NeckerInem @Uniklinikum_ER @univ_paris_cite @UP_Medecine @Inserm @CNRS @hopital_necker @HopRobertDebre 2/

[Immunity @ImmunityCP]

Online now: Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors https://t.co/OOqkPMHcyE

[Waggoner Lab @LabWaggoner]

Metallophilic CD169+ marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors using a proteasome- and cDC1-independent pathway
@FMauvaisJarvis @pvandenendert @ImmunityCP
https://t.co/oITfIE9Yky

[@realFlorentGinhoux @FGinhoux]

We are hiring! We are looking for a neuro-immunologist for a postdoc position ! Joint project with Professor Sonia Garel on the “United States of Microglia” in Development and Diseases. Please reach out !

[Rejane Rua @RejaneRua]

Neuroimmunologists fans, we're looking for a post-doc to join our team :) !!

[Université Paris Cité @univ_paris_cite]

Disparition inquiétante | Ling-Diane Zhang, étudiante en 6e année de médecine à Université Paris Cité, a disparu le mardi 16 janvier.
Toute personne ayant des informations est invitée à contacter la police au 17 ou la gendarmerie au 01.64.81.90.85.
N’hésitez pas à relayer ces informations.