Jim Baggen

Postdoc @KULeuven Rega Institute @Daelemanslab | Virus-host interactions | Drug resistance | CRISPR screening

[Jim Baggen @BaggenJim]

Our new paper is now online! We found that SARS-CoV-2 can use TMEM106B as cell entry receptor. Spike substitution E484D increases binding to TMEM106B.
@CellCellPress @DaelemansLab

https://t.co/oNRRdlFmOc

[Nature Portfolio @NaturePortfolio]

A @Nature paper describes coronaviruses that are genetically similar to SARS-CoV-2, identified within bat populations in northern Laos. The study suggests that these novel bat coronaviruses may have a potential for infecting humans. https://t.co/bExtTKTmrQ

[Jim Baggen @BaggenJim]

Check out our review about cellular host factors for SARS-CoV-2 infection, which was just published in @NatureMicrobiol. Thanks to Els Vanstreels, Dirk Daelemans @DaelemansLab and Sander Jansen for their efforts!
https://t.co/U2JHP5cNye

https://t.co/cPFrUM9klt

[Daelemans Lab @DaelemansLab]

#LKI_Oncoforum_2021 Looking forward to giving a tech talk on CRISPR technology at the virtual LKI-oncoforum shortly.

[Jim Baggen @BaggenJim]

@timlevine1 Thanks for sharing this, it's a very interesting study!

[Jim Baggen @BaggenJim]

@odd_opinions5 @EricTopol @NatureGenet @KU_Leuven @leuvenresearch Yes, it was known that coronaviruses require lysosomes. However, I want to add that we found TMEM106B to be needed for SARS-CoV-2, but not HCoV-229E, suggesting a more specific role of TMEM106B than general lysosome function. Whether it is druggable still needs to be explored.

[Nature Genetics @NatureGenet]

🚨NEW CONTENT ALERT!
From @BaggenJim and colleagues: Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2 | https://t.co/UVKU34ITAQ

[Johan Neyts @neyts_johan]

Check @NeytsVirology paper in @nature on single dose fast acting vaccine candidate that protects animals against #SARSCoV2 and yellow fever. Thanks a lot/congrats Lorena Sanchez, Kai Dallmeier @hendrikthibaut1 and entire team.

Verstuurd vanaf mijn iPhone https://t.co/N8xMdM6Mlq

[Jim Baggen @BaggenJim]

I'm exited to share that our new paper is now online. We identified the lysosomal protein TMEM106B as a host factor for SARS-CoV-2.
https://t.co/OGO79cGSfX

[Nature Portfolio @NaturePortfolio]

Since early reports revealed that a new coronavirus was spreading rapidly between people, researchers have been trying to pin down whether it can travel through the air. #COVID19 https://t.co/FRgdILoC9o

[Daniel Hurdiss @DanielHurdiss]

Check out the latest paper from @BaggenJim, @hendrikthibaut1 et al. Another nice virus-host factor story from the #virology group @UniUtrecht! @mbiojournal
https://t.co/QPeOZtJpBO

[Jim Baggen @BaggenJim]

Our paper describing an enterovirus D68 strain that bypasses the pan-enterovirus host factor PLA2G16 is published @NatureComms: https://t.co/OPo4KmiydZ

For a summary see: https://t.co/ITMBI2vbah