Thomas Bajaj

Neuroscientist interested in autophagy, lysosome biology, organelle homeostasis and molecular biology of glucocorticoid signaling @UniklinikBonn

[Joeri Bordes @joeribordes]

We've uncovered sex-specific effects of early-life stress (ELS) exposure on fear memory, HPA-axis regulation, and brain metabolism🧠. Unsupervised clustering shows that fear responses are more than only freezing @CommsBio https://t.co/S8PF6VaTEY
Highlights in thread👇

[Thomas Bajaj @BajajThomas]

Check out our new preprint here:
https://t.co/d6dRR5mE9B

[Thomas Bajaj @BajajThomas]

Spermidine supplementation restores polyamine balance and boosts autophagy under stress, presenting a promising, well-tolerated treatment for stress-related depression!
@harvardmed @McLeanHospital
@UniGraz @MedUniGraz spearheaded by @GassenNils Lab @UniklinikBonn.🧠

[Nature Cell Biology @NatureCellBio]

💫NEW: @seb_hofer et al. show that fasting promotes the synthesis of #spermidine, which stimulates eIF5A hypusination to induce #autophagy and increase #lifespan in various species in a conserved manner.
@UniGraz
https://t.co/wQFYm451Tx

[Sebastian J. Hofer @seb_hofer]

🥂Thrilled to see my latest #postdoc work out! What began as a quick, fun side project just before the first lockdown led me down a rabbit hole and ended in @NatureCellBio 4.5y later:

https://t.co/vRSwB4ko0j

#autophagy #polyamines #fasting #caloricrestriction🧵1/11

[Thomas Bajaj @BajajThomas]

Check out our SKA2 Punctum in Autophagy on our fascinating paper about SKA2-regulated Secretory Autophagy from the @jakobhartmann28 and @GassenNils labs, recently published in @NatureComms! 🧠🔥
👇https://t.co/P7rUdFZYWo
+
https://t.co/9zm2AlSqHm

[Science Signaling @scisignal]

Inhibitors of the kinases MST1/2 in #HippoSignaling boost memory in aged mice and models of #AlzheimersDisease by promoting the incorporation of the scaffolding protein WWC1 into AMPAR complexes, show new experiments from @GassenNils lab. @mpi_psychiatry https://t.co/Cacta2ymEq

[Thomas Bajaj @BajajThomas]

Memory Breakthrough from the @GassenNils Lab: Disrupting Hippo Kinases to Supercharge Synaptic Plasticity and Memory in Mice! 🧠
Check it out 👇🏼
https://t.co/5vSTtWvHsU

[Marcel A. Muller @MarcelAMller]

Great retreat supported by @StiftungCharite with the team of guest prof @GassenNils from @UKBonn and my team from @ChariteBerlin trailblazing research on #stress & #infection

[Jakob Hartmann @jakobhartmann28]

So happy to finally see our study on novel regulators of secretory autophagy and their impact on neuroinflammation published in @NatureComms 🧠🔥🔬 Incredibly thankful to all my co-authors for their contributions! https://t.co/T1TAYqvUXI

[Mathias Schmidt @MathiasVSchmidt]

Great new paper from the @jakobhartmann28 and @GassenNils labs, to which we were lucky to contribute. We identify a mechanism by which #SKA2 regulates #autophagy & contributes to neuroinflammation-induced neurodegeneration. Link to #Alzheimer's disease!
https://t.co/6HnDJcsDnl

[SysBioStress - Daskalakis Lab @NikosDaskalakis]

🧬💡Excited to share our work @McLeanHospital @AtSpared @harvardmed @broadinstitute on cell-type-specific molecular underpinnings of #PTSD @APAPubJournals #AJP ! It represents the 1st #singlecell study of dorsolateral prefrontal cortex #PFC in PTSD! https://t.co/OH5s7GweQF 1/x

[Thomas Bajaj @BajajThomas]

@WowTerrifying https://t.co/YRYnOyLmX8

[Mathias Schmidt @MathiasVSchmidt]

Check out this impressive new paper by @jakobhartmann28 and colleagues, uncovering a new mechanism how the psychiatric risk factors Ska2 and FKBP5 impact secretory autophagy and neuroinflammation. Huge implications for psychiatric disorders. Happy we could contribute.

[Jakob Hartmann @jakobhartmann28]

Interested in mechanisms of neuroinflammation? Check out our preprint demonstrating that SKA2 and FKBP5 impact neuroinflammation via regulation of secretory autophagy.
Huge team effort with @GassenNils and Kerry Ressler @AtSpared and many more!
https://t.co/qaEuAvoNuV

[Thomas Bajaj @BajajThomas]

Truly stimulating work from the @GassenNils lab just out in @CellReports!
🫘🧠⚡️🦛 >💡🐭 🆙
Uncoupling KIBRA/WWC1 from the Hippo pathway to AMPAR-reg. complexes promotes long-term memory formation. Wonderful study and graphical abstract by @matteosciart
https://t.co/e3hmIVgxa2

[Thomas Bajaj @BajajThomas]

@MathiasVSchmidt @ahaeusl Fantastic! Congratulations Alex!🥂

[Marcel A. Muller @MarcelAMller]

Long-term collaborator @GassenNils from #UKBonn will join #ChariteVirology as guest prof to study with me the differential stress response and inflammation during virus infections in bats vs. human cells. Thanks @StiftungCharite @ChariteBerlin @c_drosten
https://t.co/jW4UrJM9nq

[Thomas Bajaj @BajajThomas]

Thank You @NatureComms for featuring our research on CoV-2-mediated dysregulation of metabolism and autophagy among the most impactful and innovative articles in your COVID-19 collection: https://t.co/By9iFoF2Ef
Check it out! https://t.co/LFSuaqzU0I
@GassenNils and @MarcelAMller

[Mathias Schmidt @MathiasVSchmidt]

@GassenNils and I recently did a podcast on #stress #resilience, FKBP51, #autophagy and #metabolism. Check it out here https://t.co/LmPTkF4vjH
Thanks to @dr_eeks for the fun interview.