We've uncovered sex-specific effects of early-life stress (ELS) exposure on fear memory, HPA-axis regulation, and brain metabolism🧠. Unsupervised clustering shows that fear responses are more than only freezing @CommsBio https://t.co/S8PF6VaTEY
Highlights in thread👇
💫NEW: @seb_hofer et al. show that fasting promotes the synthesis of #spermidine, which stimulates eIF5A hypusination to induce #autophagy and increase #lifespan in various species in a conserved manner.
@UniGraz
https://t.co/wQFYm451Tx
Check out our SKA2 Punctum in Autophagy on our fascinating paper about SKA2-regulated Secretory Autophagy from the @jakobhartmann28 and @GassenNils labs, recently published in @NatureComms! 🧠🔥
👇https://t.co/P7rUdFZYWo
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https://t.co/9zm2AlSqHm
Inhibitors of the kinases MST1/2 in #HippoSignaling boost memory in aged mice and models of #AlzheimersDisease by promoting the incorporation of the scaffolding protein WWC1 into AMPAR complexes, show new experiments from @GassenNils lab. @mpi_psychiatry https://t.co/Cacta2ymEq
Memory Breakthrough from the @GassenNils Lab: Disrupting Hippo Kinases to Supercharge Synaptic Plasticity and Memory in Mice! 🧠
Check it out 👇🏼
https://t.co/5vSTtWvHsU
So happy to finally see our study on novel regulators of secretory autophagy and their impact on neuroinflammation published in @NatureComms 🧠🔥🔬 Incredibly thankful to all my co-authors for their contributions! https://t.co/T1TAYqvUXI
Great new paper from the @jakobhartmann28 and @GassenNils labs, to which we were lucky to contribute. We identify a mechanism by which #SKA2 regulates #autophagy & contributes to neuroinflammation-induced neurodegeneration. Link to #Alzheimer's disease!
https://t.co/6HnDJcsDnl
Check out this impressive new paper by @jakobhartmann28 and colleagues, uncovering a new mechanism how the psychiatric risk factors Ska2 and FKBP5 impact secretory autophagy and neuroinflammation. Huge implications for psychiatric disorders. Happy we could contribute.
Interested in mechanisms of neuroinflammation? Check out our preprint demonstrating that SKA2 and FKBP5 impact neuroinflammation via regulation of secretory autophagy.
Huge team effort with @GassenNils and Kerry Ressler @AtSpared and many more!
https://t.co/qaEuAvoNuV
Truly stimulating work from the @GassenNils lab just out in @CellReports!
🫘🧠⚡️🦛 >💡🐭 🆙
Uncoupling KIBRA/WWC1 from the Hippo pathway to AMPAR-reg. complexes promotes long-term memory formation. Wonderful study and graphical abstract by @matteosciart
https://t.co/e3hmIVgxa2
Thank You @NatureComms for featuring our research on CoV-2-mediated dysregulation of metabolism and autophagy among the most impactful and innovative articles in your COVID-19 collection: https://t.co/By9iFoF2Ef
Check it out! https://t.co/LFSuaqzU0I
@GassenNils and @MarcelAMller