Joeri Bordes

Find me at @joeribordes.bsky.social
Postdoc at Neurocentre Magendie - French Institute of Health (INSERM) | Triathlete and runner.

[Joeri Bordes @joeribordes]

We've uncovered sex-specific effects of early-life stress (ELS) exposure on fear memory, HPA-axis regulation, and brain metabolism🧠. Unsupervised clustering shows that fear responses are more than only freezing @CommsBio https://t.co/S8PF6VaTEY
Highlights in thread👇

[Joeri Bordes @joeribordes]

@CommsBio 8) Special thanks to @DeepLabCut , an open-source tool, which enabled this study to utilise more accurate and increased animal pose-estimation information.

If you would like to use DeepOF for supervised and unsupervised behavioral analysis, see here: https://t.co/guiTMzS3FE

[Joeri Bordes @joeribordes]

We've uncovered sex-specific effects of early-life stress (ELS) exposure on fear memory, HPA-axis regulation, and brain metabolism🧠. Unsupervised clustering shows that fear responses are more than only freezing @CommsBio https://t.co/S8PF6VaTEY
Highlights in thread👇

[Joeri Bordes @joeribordes]

@CommsBio 7) This work wouldn't have been possible without the contributions of the co-authors @MathiasVSchmidt @BajajThomas @GassenNils @lucasmiranda422 @svnarayan_ @MitraShiladitya @veron_kovarova @KarinKleigrewe and other co-authors without X.

[Joeri Bordes @joeribordes]

@CommsBio 6) 🌟 Conclusion:

ELS impacts stress-related neurobiology differently in males & females.
HPA-axis dysregulation, altered fear memory, & brain metabolism may inform sex-specific interventions for stress-related disorders.
Check out the full study for details!

[Joeri Bordes @joeribordes]

@CommsBio 5) Brain metabolism alterations by ELS:

ELS altered purine & glutamate metabolism pathways in the BLA, dHIP, & vHIP.

Sex differences in these pathways might explain distinct behavioral outcomes.

Linking brain metabolism to stress response is key!

[Joeri Bordes @joeribordes]

@CommsBio 4) 🚀 Using the open-source package DeepOF, we performed unsupervised analysis of fear behaviors. This revealed novel sex-specific patterns, in which females showed more active fear response (darting-like behavior) via explorative behaviors, that males did not show.

[Joeri Bordes @joeribordes]

@CommsBio 3) 🔍 Fear memory formation is altered on freezing:

ELS exposure reduces freezing behavior during fear retrieval especially in males.

[Joeri Bordes @joeribordes]

@CommsBio 2) 🧬 We show that ELS affects HPA-axis regulation differently in males & females:

Females: Persistent body weight effects & elevated baseline CORT early on

Males: Altered adrenal weight & delayed recovery of HPA-axis function

Sex matters in stress response!

[Joeri Bordes @joeribordes]

@CommsBio 1) Early life stress (ELS) increases vulnerability to stress-related disorders, such as PTSD, often with sex-specific impacts. Using a mouse model, we explored how ELS alters:
- HPA-axis regulation
- Fear memory acquisition & retrieval using
- Brain metabolomic pathways

[Marija Kundakovic @KundakovicLab]

Had such nice time in Mainz @ #RESILIENCE2024 - great, interdisciplinary science, top-notch entertainment. Europe really knows how to do it! Great hanging out w/ @Der_Scientist @clbockting . What an amazing night w/ fantastic band, food adventure, everyone dancing! @joeribordes

[Joeri Bordes @joeribordes]

@MathiasVSchmidt @mpi_psychiatry Beautiful 🤣🤣🤩

[Joeri Bordes @joeribordes]

@EuropeStress What a great list of speakers 🤩

[ResilienceResearch @ResilienceRes]

#resilience2024: 10th Intl Symposium on Resilience Research - Again a wonderful lineup of speakers: https://t.co/G9QHPJ8oeg and an exciting program: https://t.co/0ctDXgDX69 4all fans of #stress + #resilience research. Registration will be open soon. Meet us in Mainz, Sept 25-27.

[Joeri Bordes @joeribordes]

Big congrats to Simon and all co-authors for this amazing experimental design, including many state-of-the-art techniques and analyses. You are showing us the way we should perform such studies! Can't wait to fully dig in!

[Simon Chang @Simon_CEChang]

Check out my latest preprint with @FermaniFederica and @caina89: “Molecular and neural mechanisms of behavioural integration in the extended-amygdala”, now on biorxiv! https://t.co/72iuFTDpQv 1/n

[Joeri Bordes @joeribordes]

Always amazing to reconnect with Mathias and happy to meet one of the most influential scientists in Dutch (stress) research!!

[Mathias Schmidt @MathiasVSchmidt]

3 generations of stress scientists and a science family reunion at the first Global Stress and Resilience Network Meeting @GSRNet_ @carmensandi10 @quervain_de

[Joeri Bordes @joeribordes]

Many thanks to all co-authors for their invaluable contributions!! @BajajThomas @lucasmiranda422 @LDoeselaar @svnarayan_ @MitraShiladitya @veron_kovarova @KarinKleigrewe @GassenNils @MathiasVSchmidt and x-less Lea Brix, Huanqing Yang, Margherita Springer, Bertram Müller-Myhsok

[Joeri Bordes @joeribordes]

New preprint from my PhD work! We find sex-specific differences in fear acquisition behavior using deep phenotyping strategies via #DLC and #DeepOF analysis. Also, we show alterations in glutamate metabolism via metabolomics analysis related to sex and stress exposure.

[Mathias Schmidt @MathiasVSchmidt]

New pre-print from the lab on early life stress & fear: Sex matters! Our study shows how stress impacts females & males differently, linked to brain chemistry. Featuring deep phenotyping of fear conditioning behavior using #DeepLabCut and #DeepOF
https://t.co/PeCv8PPWGE

[Mathias Schmidt @MathiasVSchmidt]

New pre-print from the lab on early life stress & fear: Sex matters! Our study shows how stress impacts females & males differently, linked to brain chemistry. Featuring deep phenotyping of fear conditioning behavior using #DeepLabCut and #DeepOF
https://t.co/PeCv8PPWGE

[European Research Council (ERC) @ERC_Research]

📣 Hot off the press: Transitional arrangements will allow the ERC to begin accepting applications from researchers based in 🇨🇭Switzerland once again, as from the calls under the ERC’s 2024 Work Programme.

Statement from the ERC's Scientific Council 👇
https://t.co/e0amuhwrAd

[Juan Pablo Lopez @JPablo_Neuro]

I'm very happy to share our new study published today in @ScienceAdvances showing how Early Life Adversity leads to social deficits later in life. It was great to work on this one with my best friends Aron Kos and @JulienDine at @alon_chen_lab.

https://t.co/FUphEPBNoa