We've uncovered sex-specific effects of early-life stress (ELS) exposure on fear memory, HPA-axis regulation, and brain metabolism🧠. Unsupervised clustering shows that fear responses are more than only freezing @CommsBio https://t.co/S8PF6VaTEY
Highlights in thread👇
@CommsBio 8) Special thanks to @DeepLabCut , an open-source tool, which enabled this study to utilise more accurate and increased animal pose-estimation information.
If you would like to use DeepOF for supervised and unsupervised behavioral analysis, see here: https://t.co/guiTMzS3FE
We've uncovered sex-specific effects of early-life stress (ELS) exposure on fear memory, HPA-axis regulation, and brain metabolism🧠. Unsupervised clustering shows that fear responses are more than only freezing @CommsBio https://t.co/S8PF6VaTEY
Highlights in thread👇
@CommsBio 6) 🌟 Conclusion:
ELS impacts stress-related neurobiology differently in males & females.
HPA-axis dysregulation, altered fear memory, & brain metabolism may inform sex-specific interventions for stress-related disorders.
Check out the full study for details!
@CommsBio 5) Brain metabolism alterations by ELS:
ELS altered purine & glutamate metabolism pathways in the BLA, dHIP, & vHIP.
Sex differences in these pathways might explain distinct behavioral outcomes.
Linking brain metabolism to stress response is key!
@CommsBio 4) 🚀 Using the open-source package DeepOF, we performed unsupervised analysis of fear behaviors. This revealed novel sex-specific patterns, in which females showed more active fear response (darting-like behavior) via explorative behaviors, that males did not show.
@CommsBio 2) 🧬 We show that ELS affects HPA-axis regulation differently in males & females:
Females: Persistent body weight effects & elevated baseline CORT early on
Males: Altered adrenal weight & delayed recovery of HPA-axis function
Sex matters in stress response!
@CommsBio 1) Early life stress (ELS) increases vulnerability to stress-related disorders, such as PTSD, often with sex-specific impacts. Using a mouse model, we explored how ELS alters:
- HPA-axis regulation
- Fear memory acquisition & retrieval using
- Brain metabolomic pathways
Had such nice time in Mainz @ #RESILIENCE2024 - great, interdisciplinary science, top-notch entertainment. Europe really knows how to do it! Great hanging out w/ @Der_Scientist@clbockting . What an amazing night w/ fantastic band, food adventure, everyone dancing! @joeribordes
#resilience2024: 10th Intl Symposium on Resilience Research - Again a wonderful lineup of speakers: https://t.co/G9QHPJ8oeg and an exciting program: https://t.co/0ctDXgDX69 4all fans of #stress + #resilience research. Registration will be open soon. Meet us in Mainz, Sept 25-27.
Big congrats to Simon and all co-authors for this amazing experimental design, including many state-of-the-art techniques and analyses. You are showing us the way we should perform such studies! Can't wait to fully dig in!
Check out my latest preprint with @FermaniFederica and @caina89: “Molecular and neural mechanisms of behavioural integration in the extended-amygdala”, now on biorxiv! https://t.co/72iuFTDpQv 1/n
3 generations of stress scientists and a science family reunion at the first Global Stress and Resilience Network Meeting @GSRNet_@carmensandi10 @quervain_de
New preprint from my PhD work! We find sex-specific differences in fear acquisition behavior using deep phenotyping strategies via #DLC and #DeepOF analysis. Also, we show alterations in glutamate metabolism via metabolomics analysis related to sex and stress exposure.
New pre-print from the lab on early life stress & fear: Sex matters! Our study shows how stress impacts females & males differently, linked to brain chemistry. Featuring deep phenotyping of fear conditioning behavior using #DeepLabCut and #DeepOF
https://t.co/PeCv8PPWGE
New pre-print from the lab on early life stress & fear: Sex matters! Our study shows how stress impacts females & males differently, linked to brain chemistry. Featuring deep phenotyping of fear conditioning behavior using #DeepLabCut and #DeepOF
https://t.co/PeCv8PPWGE
📣 Hot off the press: Transitional arrangements will allow the ERC to begin accepting applications from researchers based in 🇨🇭Switzerland once again, as from the calls under the ERC’s 2024 Work Programme.
Statement from the ERC's Scientific Council 👇
https://t.co/e0amuhwrAd
I'm very happy to share our new study published today in @ScienceAdvances showing how Early Life Adversity leads to social deficits later in life. It was great to work on this one with my best friends Aron Kos and @JulienDine at @alon_chen_lab.
https://t.co/FUphEPBNoa