Brandon Clark

Too many school boys not enough rude boys

[RNB RADAR @rnbradar]

Chaka Khan performing ‘Through the Fire’ for COLORS ❤️‍🔥

[Podcast Alpha @PodcastAlphaX]

$GOOGL has an anti-aging asset nobody is pricing.

Friedberg @friedberg walked through a Calico paper that should be on Alphabet holders' radar. Calico is Google's longevity lab. Working with Revel Pharma, it used AlphaFold plus directed evolution to design a novel enzyme that degrades CML, the glycation end-product that stiffens tissue and drives aging.

The result is not a slide. Across five recursive design cycles the enzyme degraded **52-97%** of CML on human proteins, and on donated skin from patients over 70 it eliminated about **55%** of CML - reversing the skin's profile toward that of a 31-year-old. It is AI-designed proteins doing something genuinely new in biology, not a benchmark score. Chamath @chamath frames the first market as cosmetic: a workable anti-aging cream is a multi-trillion-dollar category.

This is the AlphaFold thesis paying out in a product line, and the AlphaFold-to-drugs bridge is exactly what Demis Hassabis @demishassabis has argued is the real near-term return on Google's AI - not chatbots, but designed molecules. Same company, same stack, a second revenue engine the market files under "research."

Implication: this is deep-optionality inside a name you already hold on search and cloud. It does not move the $GOOGL model this year. But it is a reminder that Alphabet's AI edge shows up in drug and materials design, an option the Street assigns roughly zero value. If a Calico or Isomorphic asset reaches a real market, that is upside no analyst is underwriting.

Watch for Calico or Isomorphic Labs to move a designed molecule toward a commercial or clinical path.

[AshutoshShrivastava @ai_for_success]

Fabel 5 vs Kimi K3.

[Brandon Clark @Bclark796]

Wow

[SpamD @SpamDxw]

Need that

[Saltyandy 🇺🇸 🇺🇸 🇺🇸 🇨🇦 @BialkoAndrew68]

🫣😂🤣😂🤣😂

[Dear Son. @DearS_o_n]

Dear son, know the difference.

[Deep Psychology @DeepPsycho_HQ]

“If everybody is thinking alike, then somebody isn’t thinking.”

- George S. Patton

[Brandon Clark @Bclark796]

@mchooyah Well some seed and an apple pie sure as shit won’t kill anyone. Thanks for what you did my guy

[The Best @TheBestqueenx]

Real life Timon riding Pumbaa in the African savanna. 😂

[Brandon Clark @Bclark796]

He said it

[Monkeyjunk11 @Monkeyjunk11]

🤣🤣

[Brandon Clark @Bclark796]

That’s sweet

[Nastya Gornaya @nastyagornaya]

Anaesthesia.

Zenit 122, Kodak Ultramax 400