Bence Daniel

Principal Scientist @genentech, Epigenetics and Chromatin Biology.

[Bence Daniel @BenceDaniel2]

Further studies are needed to better understand this mechanism and how widespread it is among cancer types and treatments.

[Bence Daniel @BenceDaniel2]

Exciting news, first preprint from my group @Genentech, led by Vasumathi Kameswaran. We studied TEAD/YAP-addicted mesothelioma cells, and how they resist a pan-TEAD inhibitor. They revert to an old-school way of gene regulation…promoters: https://t.co/12Df9fmNgl

[Bence Daniel @BenceDaniel2]

We introduce the "Promoter-switch" concept as an adaptation mechanism in cancer cells when selective pressure targets TEAD/YAP-bound distal elements, shifting reliance to promoter-centric gene regulation.

[Wei Xie @xielablife]

Less than one month away from abstract submission deadline for the 2025 GRC/GRS Genome Architecture meeting at the beautiful beach in California. Don't miss it!

[Ansu Satpathy @Satpathology]

Happy to share our latest study asking whether exhausted T cells can form memory? Terrific work led by Colin Raposo and @InflammatoryDC

[Cartography Biosciences @CartographyBio]

On #IDWGS, we celebrate women transforming the way we tackle global challenges. From breaking stereotypes to mentoring the next generation, their contributions are shaping the future. We're proud to highlight the stories & wisdom of the #womeninscience at Cartography.

[Caleb Lareau @CalebLareau]

PERFF-seq is out today in @NatureGenet! Our recent thread summarizes why we are excited about the prospects of programmable nucleic acid cytometry for studying rare cell states.

https://t.co/pJZh23AZ1f

[Howard Chang @HowardYChang]

I am excited to join storied biotech pioneer @Amgen as Chief Scientific Officer and Head of Research. I look forward to partnering with my new colleagues to deepen understanding of biology and develop solutions to the most pressing medical challenges https://t.co/Vqmsv68Q9Z

[Bence Daniel @BenceDaniel2]

@kinglhung @Nature Congrats to all involved!

[Bence Daniel @BenceDaniel2]

wow, an amazing synthetic biology approach, congrats to all involved!

[Ansu Satpathy @Satpathology]

Happy to share our new work describing DESynR genes!

The evolution of new human protein-coding genes relies on repurposing protein domains from ancestral genes, rather than de novo sequence creation. New genes evolved from old parts, and while we have methods that enable high-throughput generation and screening of base-pair level sequence evolution (mutagenesis, directed evolution, CRISPR, etc), we lack similar scalable technologies for domain-level evolution.

We developed a high-throughput combinatorial molecular assembly method to generate thousands of barcoded novel genes from the domain building blocks of natural genes, termed DESynR (Domain Engineered via Synthesis and Recombination) genes.

[Bence Daniel @BenceDaniel2]

@SagerGosai @Nature wow, awesome, congrats! Love that you tested the sequences - what a result...