Benjamin Lau

.. interested in fundamental questions of RNA-protein biology.

EIPOD PostDoc @EMBL, Duss and Mahamid Group

[Benjamin Lau @Benjamin_Lau_hd]

Hot and splicy 🔥 Check out spliceosome complexes under quality control by GPATCH1-DHX35! #spliceosome #somelikeithot #hotandsplicy We establish C. Thermophilum as serious player when it comes to spliceosomes. https://t.co/qVbTi6p32Q

[Benjamin Lau @Benjamin_Lau_hd]

In ribosome biogenesis, being too early can be just as bad as being wrong.
Amazing collaboration @Cheng and @Beckmann Labs
https://t.co/1emlevHOGQ

[Benjamin Lau @Benjamin_Lau_hd]

In ribosome biogenesis, a Rio1-dependent checkpoint controls the decoding center maturation in the cytoplasm. But what if Rio1 starts quality control much earlier?

Our Cell Reports study reveals a nucleoplasmic decoding center checkpoint controlled by Rrp12.

[Benjamin Lau @Benjamin_Lau_hd]

Rrp12 ensures the timely, ordered maturation of the decoding center during early 40S assembly. We find that premature stabilization of h28 disrupts downstream small-subunit biogenesis and triggers early Rio1 surveillance.

[Cell Research @cell_res]

Jingdong Cheng's lab elucidates how DHX35 helicase and its cofactor GPATCH1 proofread an aberrant 5’ splice site in a catalytically activated spliceosome by unwinding the U2 RNA-branch site helix, ensuring splicing fidelity.
🔗https://t.co/sKvxGTZf1o
@FudanUniv

[Benjamin Lau @Benjamin_Lau_hd]

With the GPATCH1-DHX35 and TFIP11-DHX15 pairs present, our work opens intriguing questions regarding splicing fidelity. Great collaboration between the Hurt, @jingdongcheng,
@Fei_Xavier_Chen and Lührmann labs. Special thanks to Reinhard Lührmann for guiding us ribosome folks!

[Benjamin Lau @Benjamin_Lau_hd]

Hot and splicy 🔥 Check out spliceosome complexes under quality control by GPATCH1-DHX35! #spliceosome #somelikeithot #hotandsplicy We establish C. Thermophilum as serious player when it comes to spliceosomes. https://t.co/qVbTi6p32Q

[Benjamin Lau @Benjamin_Lau_hd]

Known to regulate splicing of pre-mRNAs with non-canonical splice sites, we provide fiery structural details into the action of GPATCH1-DHX35. @Komal_soni02 reported similar insights from S. Pombe, suggesting a conserved route to mitigate a common source of error during splicing.

[Jingdong Cheng @jingdongcheng]

Our latest study, in collaboration with the Hurt lab, @Benjamin_Lau_hd , @Fei_Xavier_Chen and Reinhard Lührmann, reveals how DHX35 and GPATCH1 work together to reject aberrant splicing substrates, ensuring splicing fidelity. #CryoEM #Splicing #Spliceosome
https://t.co/dm3KkpLoJn

[Benjamin Lau @Benjamin_Lau_hd]

@OlivierDuss @ERC_Research @embl Congrats! Well deserved.

[Benjamin Lau @Benjamin_Lau_hd]

Really cool story and impressive work!

[Olivier Duss @OlivierDuss]

First paper of our lab today @Nature by Nussi!

We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! @embl

https://t.co/ui1h01VaQW

[Benjamin Lau @Benjamin_Lau_hd]

@jingdongcheng @GreenLabJHMI @embojournal Congrats, nice work!

[Benjamin Lau @Benjamin_Lau_hd]

This was fun to be part of! Major effort from the Hurt and Beckman labs, revealing an H/ACA snoRNP on the pre-ribosome.

[Beckmann Lab @BeckmannLab]

First structure of a H/ACA snoRNP acting in ribosome synthesis. In a great collaboration with the Hurt lab, we provide a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇