Komal Soni

Staff Scientist @UniBayreuth
Passionate about structural biology of protein-RNA complexes

[Komal Soni @Komal_Soni02]

Spliceosomes use quality control mechanisms to detect and correct mistakes during RNA processing. Our work explores how defective spliceosomes are identified and discarded. #RNA #RNAProcessing #Spliceosomes #QualityControlMechanisms #RMAP

https://t.co/IjYgWUr7Pr

[Carlomagno Group UoB @CarlomagnoNMR]

Pravin Jagtap presents novel mechanisms through which RNA helicases are regulated. @UoBbiosciences
Read more here https://t.co/kbvtntMUlu

[Sebastian Glatt @GlattSebastian]

We are very excited about our latest work, which just came out @embojournal – https://t.co/fXvRgVMu1I. The work @MCB_UJ was driven by Anna Biela and @TingYuLin1031 in collaboration with Janusz Bujnicki and his team @IIMCB_Poland…a short🧵

[Nature Methods @naturemethods]

Introducing spIsoNet, a software tool that addresses the challenges of map anisotropy and particle misalignment in cryo-EM caused by the preferred orientation problem.
@zhou_lab @yuntaoinnit @hongcheng_fan

https://t.co/vViLnZWwie

[Komal Soni @Komal_Soni02]

We propose that the Gpl1-Gih35 complex is involved in a new Splicing Quality Control mechanism in the discard pathway where it initiates the process of disassembly by the Ntr1 complex.
(7/7)

[Komal Soni @Komal_Soni02]

📢Delighted to share our preprint on cryo-EM structures of aberrant spliceosome intermediates from Schizosaccharomyces pombe. This work sheds light on a new splicing quality control mechanism.
Check out the full paper here: https://t.co/pJwdSRiomt
(1/7)

[Komal Soni @Komal_Soni02]

Structure superpositions with Bact and B* spliceosomes suggest that Gih35 likely acts on the branch helix in the process of disassembly.
(6/7)

[Komal Soni @Komal_Soni02]

Gpl1 has an enormous interface with Prp8 and acts as a molecular glue between Gih35 and the spliceosome. (5/7)

[Komal Soni @Komal_Soni02]

Gpl1 recognizes this altered active site conformation. The largely unstructured Gpl1 crawls into the active site where it also extensively interacts with the 1585-loop of Prp8. (4/7)

[Molecular Cell @MolecularCell]

eIF4F is a thermo-sensing regulatory node in the translational heat shock response https://t.co/IrhpAQ9OFG

[Abdel-Wahab Lab @AbdelWahablab]

Excited to announce our paper out today in @MolecularCell discovering a novel splicing factor GPATCH8 and its requirement for pathologic splicing activity of mutant SF3B1. With @bradleybio & @Doulatov_lab. Led by @SBenbarche, @jpineda223, & @GalvisBaquero:
https://t.co/rtTnw2ENzs

[Mandy Jeske @Jeske_Lab]

Struggling with testing interactions between structurally complex proteins? -> You may try ReLo.

Great work by x-less Harpreet and Jutta 🥳 #WomenInSTEM
Now online @NatureComms
@dfg_public

https://t.co/AxGKWrM6Tv