Thrilled to share our work at @AbdelWahablab, @bradleybio & @Doulatov_lab, out in @MolecularCell, unveiling the role of the previously uncharacterized GPATCH8 protein in the pathologic splicing activity of mutant SF3B1 through its interaction with DHX15:
https://t.co/7ESg3w5r12
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research
https://t.co/r0oyhUwRZv
Excited to announce a new paper in @CD_AACR with @junwei_s, @TomZhendong, @DaniyanMd and led by @PuZhang09980432. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in AML:
https://t.co/sxxdNVQyt1
Excited to share our paper out today in @CellPressNews discovering RNA mis-splicing derived neoantigens & their cognate T cell receptors (TCRs) as well as characterization of endogenous neoantigen T cells in leukemia patients.
https://t.co/hVucfdL0oZ
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their DNA targets. https://t.co/ketXqFVQqw
Our paper on cryptic splicing-controlled protein expression, which we hope will inspire safer and more adventurous gene therapy approaches for ALS and FTD, has been published in @ScienceMagazine https://t.co/YriG3I4ILF
PATH (phylogenetic analysis of trait heritability) is out @NatureGenet! Excited about tackling the fundamentals of somatic evolution:
*measuring cell state heritability
*a quantitative definition for cell plasticity (1-heritability)
*cell-state transition dynamics
👀🧵👇
🥁The final agenda of our 3rd iPSC-hematopoiesis symposium coorganized by @Doulatov_lab@Dr_Sturgeon and yours truly is now available! If you are attending #ISEH24 do not miss! A truly stellar speaker lineup! Thanks to our sponsors Evans MDS and @RetroBio. @ISEHSociety#iPSCLove
Now LIVE: the inaugural "Biology and Therapy of Myeloid Malignancies Conference" @Fusion_Conf taking place May 14-17, 2025 on a beautiful Minoan coast in Crete, Greece. Huge thanks to co-organizer @rosslevinemd (and @LeeGrimesLab) ! #MyeloidMalignancies25
https://t.co/WGHP39mv93
It was a great pleasure to meet and hear from the teams at @virginia_tech@FralinBiomed. Thank you so much @DrChrisHourigan for the invitation.
First-author journal clubs are fun, let's normalize them!!!