David McKellar

building tech for RNA @ Romix Bio

former @NYGCtech | @CornellBME | @NHGRI postbac

[David McKellar @dwmckellar]

@OmicsOmicsBlog The low yield (~0.1%) is why dRNA currently can't touch single-cell, spatial, or any other highly multiplexed application - probably needs to be at least ~10%. Glad they are working on it!

[David McKellar @dwmckellar]

Nothing but hot takes from @LoyConor today!

[David McKellar @dwmckellar]

@notSoJunkDNA @iskander Actually most of those transcripts are polyadenylated (but only sometimes!)

[David McKellar @dwmckellar]

https://t.co/C0YdUZMZMZ

Cool to see someone using this tool! People throw away way too much data

[David McKellar @dwmckellar]

@ahmetfcoskun @davidvanvalen @ahmetcoskun_lab @XiuweiZhang Seems to me like an excellent philanthropic opportunity for Coca Cola... Congrats!

[David McKellar @dwmckellar]

@z_chiang Definitely - I think my point was that even if personalized medicine isn't the plot, it is the climax/conclusion (still figuring out this metaphor...)

[David McKellar @dwmckellar]

@z_chiang I would love to see that plotted over time. I'd have a hard time believing that more than 50% of current short read capacity is used for WGS right now

[David McKellar @dwmckellar]

@AdamDraper @BoostVC When will you be getting that jacket with the boost logo on the back?

[David McKellar @dwmckellar]

@NikoMcCarty I think N6 is probably worth a mention in the postscript as well!
https://t.co/HDiRWfLFP2

[David McKellar @dwmckellar]

@CornellBME @IwijnDeVlaminck @LoyConor @Cornell @Cornell_CTL @CornellEng @CornellNews Don't forget co-founder number 3, @CornellBME alum @dwmckellar! Lol

[Cornell Biomedical Engineering @CornellBME]

From lab to startup, faster. Cornell’s Ignite program is helping biomed research reach real patients.
@IwijnDeVlaminck & Ph.D. student @LoyConor '24 turned cell-free RNA research into Romix Biosciences—advancing earlier detection & personalized care. https://t.co/FGDnqjEnlk

[David McKellar @dwmckellar]

This data (and several other factors...) was what convinced me to co-found @romixbio

Reach out if you want to learn more about cell-free RNA!

[Iwijn De Vlaminck @IwijnDeVlaminck]

CAR-T is effective for B cell lymphoma, but not for all patients. RNA profiling of the tumor microenvironment can inform response, but requires biopsies.

We ask whether TME signals can be detected in blood via cell-free RNA. The data are encouraging:

https://t.co/aoWhPT4ePE

[David McKellar @dwmckellar]

@OmicsOmicsBlog Maybe the best blog title I've seen this year

[David McKellar @dwmckellar]

@GorinGennady Reminds me of one of my favorite recent single-cell tech papers from @AdamCribbs -

check out Fig 1 - https://t.co/Hw45C3NbI9

[David McKellar @dwmckellar]

https://t.co/VQumrhgnWB

[David McKellar @dwmckellar]

Spatial transcriptomics needs to look beyond just mRNAs.

Great to see this work from @ntekasi, Lena Takayasu, @IwijnDeVlaminck, and me in a past life out today!

[David McKellar @dwmckellar]

@kenbwork 200+ known chemical modifications, 1000s of new transcripts/isoforms added to gencode annually- mRNA tools may be maturing, but tools to actually profile RNA are in early days

[David McKellar @dwmckellar]

Congrats to RNA-multiomics evangelist @ntekasi on defending your PhD today!

Loved that this slide happened to be # 42 in the deck!

[David McKellar @dwmckellar]

Looking forward to catching up with folks at the NYC RNA Symposium w/ @Tri_I_RNA tomorrow!