We are the Zhou Lab @UCLA. We use #cryoEM and #cryoET to study viruses, viral proteins, protein assemblies, and membrane proteins. Student-curated account.
We're so proud to be featured on the cover of @nature! Brilliant work from Dr. Peng Ge and team, uncovering intricacies of the fascinating P. aeruginosa bacteriocin at high resolution using #cryoEM.
This week on the Nature cover: Molecular syringe. High-resolution structures shed light on the workings of an antibacterial nanomachine. Browse the issue here: https://t.co/hX97FaLYX2
Here is the link to the article. https://t.co/X827BSBs6y
We are also excited to see the accompanying paper on the doublet structure of trypanosomatid parasites from the labs of Rui Zhang and Alan Brown.
https://t.co/ndzOOrEOle
Our study on the atomic structure of the T. brucei microtubule, has been published in Science and featured in UCLA News! This work was led by Dr. Xia @xianxia13 in collaboration with colleagues from Dr. Kent Hill's and Dr. James Wohlschlegel's labs.
https://t.co/z0eWGQJrVT
Excited to share our latest work: Using cryoET, we unraveled the in situ structure of a methanogen surface layer and its cell envelope. Now published in Science Advances! #teamtomo https://t.co/9Hu5tb7poY
Please check out our just published Nature paper "Native DGC structure rationalizes muscular dystrophy-causing mutations", the excellent teamwork from @ShihengLiu @ tiantiansu and @xianxia13
Thrilled to share our latest work: native cryo-EM structure of the Dystrophin-Glycoprotein Complex (DGC) is now published in Nature! https://t.co/UhiQFq6xbS This discovery sheds new light on the molecular basis of muscular dystrophies and pave the way to novel therapies.
Excited to share our new work! We shed light on the sociology of virus-induced condensates supporting reovirus assembly and replication. Visualized using #CryoET#CryoEM and #FIBmilling
https://t.co/yYjyIipgyj
Great collab w/ @xianxia13@zhou_lab Xiaoyu Liu @gonenlab
Introducing spIsoNet, a software tool that addresses the challenges of map anisotropy and particle misalignment in cryo-EM caused by the preferred orientation problem.
@zhou_lab@yuntaoinnit@hongcheng_fan
https://t.co/vViLnZWwie
TomoNet is now published in Biological Imaging! It is a 100% GUI-based cryoET integration pipeline package. Specifically, we offer two major options for high-throughput particle picking to achieve high-resolution STA. Please check the website for details. #cryoET#teamtomo
@Jiaxing_Tan_ Thanks for trying it out! Dr. Liu regularly check the issues/questions in Google group, he should reply your question in the next few days.
Excited to share our latest work in @CellCellPress on how bluetongue virus packages its RNA & assembles its capsid inside host cells! Using #cryoET & #cryoEM, we've visualized this process with 11 structures. Great collab w @gonenlab@zhou_lab 🦠🔬
https://t.co/RvDcVGLyUL
Check out our latest preprint work on SARS-CoV-2 Nsp15:
https://t.co/v33tg9euo5
We present cryo-EM structures of SARS-CoV-2 Nsp15 bound to its physiological substrate polyU containing RNA, illuminating the basis for immune evasion tactics by coronaviruses!
Our paper is out! We resolved the sheath structure from M. Hungatei cells using cryoET. Thanks to all the coauthors @zhou_lab and Gunsalus lab.#TeamTomo https://t.co/03UaDTFVOq
We're also recruiting postdocs! DM or email if you'd like to join us in using integrated structural biology approaches combining #CryoEM and #insitu#CryoET to study #membraneproteins and molecular machines in #malaria parasites!
Check it out👇👉https://t.co/jZa2WxFdPM #teamtomo
Check out our latest paper on HIV Vif-APOBEC3H complex structure by cryo-EM:
https://t.co/gu1rBuV8iv
This has been a collaborative project between @zhou_lab and Xiaojiang Chen lab at USC.
Check out our cryoEM result of mRNA editosome in Trypanosoma brucei! Awesome collaboration with Aphasizhev lab from Boston U. Many congrats to Bruce @ShihengLiu and other coauthors for another wonderful piece of work! https://t.co/fRpZmH3Yfq
The group of Hong Zhou @MicrobioUcla & their collaborators determined the cryo-EM structure of filamentous 3-methylcrotonyl-CoA carboxylase from Leishmania tarentolae and discuss its mechanism @zhou_lab
https://t.co/gdL7WepqaO