The Zhou Lab

We are the Zhou Lab @UCLA. We use #cryoEM and #cryoET to study viruses, viral proteins, protein assemblies, and membrane proteins. Student-curated account.

[The Zhou Lab @zhou_lab]

We're so proud to be featured on the cover of @nature! Brilliant work from Dr. Peng Ge and team, uncovering intricacies of the fascinating P. aeruginosa bacteriocin at high resolution using #cryoEM.

[Nature Portfolio @NaturePortfolio]

This week on the Nature cover: Molecular syringe. High-resolution structures shed light on the workings of an antibacterial nanomachine. Browse the issue here: https://t.co/hX97FaLYX2

[The Zhou Lab @zhou_lab]

Here is the link to the article. https://t.co/X827BSBs6y
We are also excited to see the accompanying paper on the doublet structure of trypanosomatid parasites from the labs of Rui Zhang and Alan Brown.
https://t.co/ndzOOrEOle

[The Zhou Lab @zhou_lab]

Our study on the atomic structure of the T. brucei microtubule, has been published in Science and featured in UCLA News! This work was led by Dr. Xia @xianxia13 in collaboration with colleagues from Dr. Kent Hill's and Dr. James Wohlschlegel's labs.
https://t.co/z0eWGQJrVT

[The Zhou Lab @zhou_lab]

@RuiZhangWUSTL Congrats!

[Hui Wang @HuiWang007]

Excited to share our latest work: Using cryoET, we unraveled the in situ structure of a methanogen surface layer and its cell envelope. Now published in Science Advances! #teamtomo https://t.co/9Hu5tb7poY

[The Zhou Lab @zhou_lab]

Please check out our just published Nature paper "Native DGC structure rationalizes muscular dystrophy-causing mutations", the excellent teamwork from @ShihengLiu @ tiantiansu and @xianxia13

[Shiheng Liu @ShihengLiu]

Thrilled to share our latest work: native cryo-EM structure of the Dystrophin-Glycoprotein Complex (DGC) is now published in Nature! https://t.co/UhiQFq6xbS This discovery sheds new light on the molecular basis of muscular dystrophies and pave the way to novel therapies.

[Mike Martynowycz @ScienceMick]

Excited to share our new work! We shed light on the sociology of virus-induced condensates supporting reovirus assembly and replication. Visualized using #CryoET #CryoEM and #FIBmilling

https://t.co/yYjyIipgyj

Great collab w/ @xianxia13 @zhou_lab Xiaoyu Liu @gonenlab

[The Zhou Lab @zhou_lab]

Proud to see the spIsoNet is online now! Hope you enjoy using it!

[Nature Methods @naturemethods]

Introducing spIsoNet, a software tool that addresses the challenges of map anisotropy and particle misalignment in cryo-EM caused by the preferred orientation problem.
@zhou_lab @yuntaoinnit @hongcheng_fan

https://t.co/vViLnZWwie

[Chi-Min Ho @mimi1inh]

We have a fully-funded postdoc position in the
@cmholab in #NYC to study how #membraneproteins drive host-pathogen interactions in #malaria parasites using #CryoEM and #CryoET!🦠❄️🔬Email [email protected] with your CV to apply!

https://t.co/jZa2WxFLFk #teamtomo

[Hui Wang @HuiWang007]

TomoNet is now published in Biological Imaging! It is a 100% GUI-based cryoET integration pipeline package. Specifically, we offer two major options for high-throughput particle picking to achieve high-resolution STA. Please check the website for details. #cryoET #teamtomo

[The Zhou Lab @zhou_lab]

@Jiaxing_Tan_ Thanks for trying it out! Dr. Liu regularly check the issues/questions in Google group, he should reply your question in the next few days.

[The Zhou Lab @zhou_lab]

spIsoNet is available on Biorxiv and GitHub now!

[The Zhou Lab @zhou_lab]

Beautiful work from Xian @xianxia13 and our amazing collaborators!

[Mike Martynowycz @ScienceMick]

Excited to share our latest work in @CellCellPress on how bluetongue virus packages its RNA & assembles its capsid inside host cells! Using #cryoET & #cryoEM, we've visualized this process with 11 structures. Great collab w @gonenlab @zhou_lab 🦠🔬
https://t.co/RvDcVGLyUL

[Hui Wang @HuiWang007]

Our preprint of TomoNet is online now!

[Fumiaki Ito @FumiakiIto110]

Check out our latest preprint work on SARS-CoV-2 Nsp15:
https://t.co/v33tg9euo5

We present cryo-EM structures of SARS-CoV-2 Nsp15 bound to its physiological substrate polyU containing RNA, illuminating the basis for immune evasion tactics by coronaviruses!

[Hui Wang @HuiWang007]

Our paper is out! We resolved the sheath structure from M. Hungatei cells using cryoET. ⁦⁦Thanks to all the coauthors @zhou_lab⁩ and Gunsalus lab.⁦#TeamTomo https://t.co/03UaDTFVOq

[Chi-Min Ho @mimi1inh]

We're also recruiting postdocs! DM or email if you'd like to join us in using integrated structural biology approaches combining #CryoEM and #insitu #CryoET to study #membraneproteins and molecular machines in #malaria parasites!

Check it out👇👉https://t.co/jZa2WxFdPM #teamtomo

[The Zhou Lab @zhou_lab]

Congrats!

[Fumiaki Ito @FumiakiIto110]

Check out our latest paper on HIV Vif-APOBEC3H complex structure by cryo-EM:
https://t.co/gu1rBuV8iv
This has been a collaborative project between @zhou_lab and Xiaojiang Chen lab at USC.

[The Zhou Lab @zhou_lab]

Check out the recent cryoET work with our beloved colleagues in Hill lab on the flagella structure of T. Brucei. https://t.co/1qCaBLvwE6

[The Zhou Lab @zhou_lab]

Check out our cryoEM result of mRNA editosome in Trypanosoma brucei! Awesome collaboration with Aphasizhev lab from Boston U. Many congrats to Bruce @ShihengLiu⁩ and other coauthors for another wonderful piece of work! https://t.co/fRpZmH3Yfq

[The Zhou Lab @zhou_lab]

Congrats to Jason, Jane and Yuntao @yuntaoinnit

[Structure @Structure_CP]

The group of Hong Zhou @MicrobioUcla & their collaborators determined the cryo-EM structure of filamentous 3-methylcrotonyl-CoA carboxylase from Leishmania tarentolae and discuss its mechanism @zhou_lab

https://t.co/gdL7WepqaO