The Ho Lab

The Ho Lab @ColumbiaMed @Columbia_MI - using cryoEM to explore how membrane protein complexes mediate host-pathogen interactions in malaria parasites!

[Chi-Min Ho @mimi1inh]

So incredibly excited and grateful to be joining the Burroughs Wellcome Fund PATH family! Thank you @BWFUND and the selection committee members for supporting and believing in our vision, and congrats to the other 2026 PATH Investigators!!! 🥳

[ShorterLab @ShorterLab]

The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation https://t.co/qknlw6K6hd

[Alexander Sobolevsky @AlexanderSobol6]

Happy to share our new review of kainate receptor structure and gating. @shantigangwar @MariaKarela3 @LauraYen42
https://t.co/Lo9CKLmxS4

[Chi-Min Ho @mimi1inh]

Learn how our hunt for the native structure of top #antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms 👉 https://t.co/SX5vBW1ZzT 🦠🔬❄️

A team effort by @mehsehret @cmholab & Anurag Shukla @AkhilVaidya1 #cryoEM

[Jun Liu Lab @JunLiuLab]

Great work from @YueJianUSTC @YaleMicroPath @YaleMed in @PNASNews #Legionella #T4SS https://t.co/udVMSBCjQ2

[NatureStructMolBiol @NatureSMB]

New online! Dynamic TOM–TIM23 supercomplex directs mitochondrial protein translocation and sorting https://t.co/fVMIeuvhDq

[Alexander Sobolevsky @AlexanderSobol6]

Structures of kainate receptor channel GluK2 in the apo closed and open conducting states, both with 2-fold symmetrical LBD layer. To open the channel, we used agonist kainate and positive allosteric modulator BPAM but no Concanavalin A! @shantigangwar
https://t.co/r4RWqXAxCn

[Chi-Min Ho @mimi1inh]

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureSMB🥳https://t.co/5SaPnwQ4zf

Massive team effort led by @leonie_anton @mehsehret @Wenjing_Cheng_ in collaboration with @DziekanJerzy @CowmanAlan #teamtomo

[Chi-Min Ho @mimi1inh]

Thank you so much @hypothesisfund and @Yeh_Lab for supporting us in this new venture!! We're excited to get started! 🦠🔬❄️

[Hypothesis Fund @Hypothesisfund]

3/ Awardee @mimi1inh tackles the complex challenges of protein sequencing by leveraging molecular machinery made by microbes. Her work could revolutionize how we study protein function + structure, & our understanding of biology🤯.
🥳Congrats Dr. Ho! @Columbia
🙏#HFScout @Yeh_Lab

[Hypothesis Fund @Hypothesisfund]

🌠 We're thrilled to announce our latest @HypothesisFund awardees and their groundbreaking projects! From optimizing enzymes, to protein sequencing, and membrane 'functional hotspots', each of these projects holds the potential to be broadly transformative for science! 1/ 🧵

[bioRxiv Microbiology @biorxiv_micrbio]

Endogenous structure of antimalarial target PfATP4 reveals new class of apicomplexan P-type ATPase modulators https://t.co/ehz8wbjEHi #biorxiv_micrbio

[Akanksha Thawani, PhD @AkankshaThawani]

Vertebrate retrotransposons are the future of gene therapy. But how do they insert their genes? 🔥🔥

Thrilled to present part 2 of my postdoctoral work with @NogalesLab @CollinsRNPLab @berkeleyMCB where we investigate this using #CryoEM and transgene insertion in 🧪 and cells!

[Lander Lab @LanderLab]

The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex! https://t.co/77epZBAIpV

[Phil Ross @philippzross]

Love when Malaria gets a MOM shoutout! https://t.co/9iGpX9nfQK

@LlinasLab @mimi1inh

[Chi-Min Ho @mimi1inh]

So excited to be joining the Pew Scholar family! Thank you @pewtrusts for supporting and believing in our vision and congrats to the 2024 class of scholars!!! 😊 https://t.co/TVRDJgZoDC

[Chi-Min Ho @mimi1inh]

We have a fully-funded postdoc position in the
@cmholab in #NYC to study how #membraneproteins drive host-pathogen interactions in #malaria parasites using #CryoEM and #CryoET!🦠❄️🔬Email [email protected] with your CV to apply!

https://t.co/jZa2WxFLFk #teamtomo

[Young Investigators in Parasitology @YIPS_2024]

We're back! Together with #MPM/#KMCB, we are holding a Young Investigators in Parasitology Meeting (YIPs) for junior PIs! We'll have panels & group discussions on all things to do with starting a new lab.

Register here!👇👉https://t.co/EAqFBpWJGf

[Young Investigators in Parasitology @YIPS_2024]

We'll also have an AMA Panel of #newPIs in #Parasitology who recently started their labs for Postdocs interested in transitioning to independence or going on the job market soon!!!

#Postdocs_in_Parasitology come ask us anything at 3PM on Sep 15 in Clapp Auditorium @WoodsHole!

[Chi-Min Ho @mimi1inh]

Manuel Fierro from the Beck Lab and Am @WDedkhad from the @MuralidharanLab closing out #MPM2023 with a bang!! 💪