@nickmmark I don’t think this is practice changing for many… But there are myriad bad studies published these days, and this is a pretty internally and externally valid study that was reasonably well designed and ran… more than can be said for a lot of the literature out there!
@nickmmark Also it was designed to test non inferiority per the manuscript they’ve not expected an art line to show a 5% mortality reduction (no one would) but predefined 5% as the minimum safety threshold right…
@onepercentas Elite work here Mateo. Often felt (well at least since the 2018-2019 drafts as a crows fan…) that the list manager is the most important person at the club but get minimal criticism outside of true nuffies… I’d be interested to know how much turnover of their jobs there is
@Papa_Heme You can’t demand attempts at transparency and then complain about it when it’s done…. Why specifically is this paper problematic, and not just for the generic reasons that all retrospective studies have methodological issues and have to be interpreted with that in mind
@PulmCrit Obviously caveats apply but it is a source of immense frustration for me that every fever >38 in an ICU patient is reflexively met with a panculture of everything under the sun. Pre test probability is the most forgotten concept in our speciality
@Aidan_Baron In terms of other anti emetics you could try a phenothiazine (eg chlorpromazine) it’s a different chemical class of drug to droperidol / haloperidol so might not be allergic to that
@stephanamayer Great study. agree with the comments re: a select population. Additionally I think that level of sedation is really hard to achieve and patients often become uncooperative. Population they’re describing probably don’t need more than a hand hold and small amt of alfentanil
@claudetozer@Dan88872710@TMFScottP No Claude you don’t understand you see because actually all the other research that disagrees with the flawed Harvard review is wrong because it doesn’t agree with Dan’s opinion.
@CapitalCityCody Why is there an obsession with getting it “right.” Whose version of right? Sport is beautiful because it’s imperfect. People still talk about whether the ball was out of bounds (Harms) or whether Woewodin deserved it. Sport is more fun this way, it’s not that serious.
@onepercentas@daanysaeed It seems harsh to ask players to comment on an ongoing investigation. They can’t give too much away, and they already stay tight lipped at baseline. I think this is pretty mountains and molehill stuff. As you say would hope a strong statement is given when the verdict is final
@TheBackPocketAU In my mind Cerra was a clear get off and this was clear as day a week… but it sometimes feels partially like a game of spin the wheel and see which verdict it lands on