A study using an n=1 experiment with single standards at 0V CID reported that 70% of detected ions were in-source fragments (ISFs). https://t.co/kZEyjh86bf... This was extrapolated to suggest that ISFs affect all experiments to this degree. A counterpoint. https://t.co/ovGKhbsq5e
I want to tell you a story about computers, creativity and awe! (1/N)🧵
Sydney Brenner once said in 2012 that “nobody has actually read the human genome. I mean, computers have processed the human genome, but we all know computers are stupid.”
(This is a talk I gave last week..)
Happy to share our back-to-back papers in @Nature, presenting a new framework for understanding metabolism - using genomics rather than traditional biochemistry! This led to a systems-level understanding of both metabolic wiring and rewiring. @UMassChan
https://t.co/xqUUkOriko
@StevenSalzberg1@Forbes There’s a Reddit thread about him being fake. Seems you are sleuthing correctly. His bio reads ridiculous, and there’s no record of him as a professor, so far as I can tell
Dimensionality reduction can "see" structures that do not exist & miss structures that exist.
Use it sparingly and evaluate conclusions in the high dimensional data.
https://t.co/8nPybyu9Et
@CJ_NFA@JoshLekach Hey this is legit. There’s a technique in chemistry called NMR spectroscopy. You put “spin” active atoms in a strong magnetic field and they precess (spin) with a specific frequency. Different atoms have different frequencies, also different spin states!