Biondi Lab

Chemical Biology of regulatory mechanisms group @IFIBYNE
We use small compounds to understand the regulation of kinases and proteins of biomedical interest

[Biondi Lab @biondi_lab]

Happy to share that our latest paper is the new cover of @scisignal! Years of hard work and fruitful interdisciplinary collaborations helped us elucidate how PDK1 exists in distinct conformations that determine its substrate specificity. #ScienceSignaling

[Science Signaling @scisignal]

This week’s issue of #ScienceSignaling has arrived! 

Research in rodents suggests that the lungs help protect other organs from #SARSCoV2 infections, scientists explore how the conformation of a kinase shapes its substrate specificity, and more. https://t.co/iZFsr6ukIe

[Lissy Gross @lissy_gross]

Loved visiting and catching up with my PhD family @biondi_lab at their new great place at @ifibyne. Really miss working every day with this amazing team ✨

[Guadalupe Sabio @Gsabiolab]

No te pierdas a @biondi_lab. En @SEBBM_es

[Biondi Lab @biondi_lab]

It also lays the groundwork for the development of allosteric activators or inhibitors of PRKs, with potential applications in cancer, viral infections, nutrient sensing, and insulin sensitization! We invite you to read our paper using the following link https://t.co/pgLmk5EYqq

[Biondi Lab @biondi_lab]

We are excited to share our new paper published in @jbiolchem , 'Molecular insights into the regulatory landscape of PKC-related kinase-2 (PRK2/PKN2) using targeted small compounds'!

[Journal of Biological Chemistry @jbiolchem]

New in JBC press: "Researchers' study highlights the potential for developing allosteric drugs to modulate PRK2 kinase conformations and catalytic activity."
Learn more:
https://t.co/6J8bRix2ZL

[Biondi Lab @biondi_lab]

In this paper, we investigate how small compounds can allosterically modulate the formation of complexes between the kinases PDK1 and PRK2. Our work contributes to the understanding of the molecular mechanisms within the PI3-K signaling and how small molecules can regulate it!

[Biondi Lab @biondi_lab]

Time to say goodbye to @lissy_gross, who has been part of our group since 2017. We will miss you and wish you great success in your career path and new scientific projects! 🙌🚀

[Lissy Gross @lissy_gross]

Feeling a mix of emotions as I bid farewell to my academic family of these last 6+ years, @biondi_lab and @sebaklinke. Grateful for the opportunity to work alongside such brilliant minds and incredible people. And honored for having been part of @IBioBA_MPSP and @CONICETDialoga.

[IFIBYNE 🇦🇷 CONICET - UBA @ifibyne]

Seminarios IFIBYNE-FBMC 2024

Próximo Seminario de invitado presencial en el auditorio IFIBYNE.

JUEVES 21/3 – 12:00 horas – Auditorio IFIBYNE

Dr. Ricardo Biondi
@IBioBA_MPSP

“Biología Química de mecanismos regulatorios, su impacto en la fisiología y descubrimiento de fármacos”

[Instituto de Investigación en Biomedicina de BsAs @IBioBA_MPSP]

👀 Mirá, mirá…
🔬 Cómo se ve en un microscopio de fluorescencia esta línea celular, en la que trabaja Macarena Acebedo del grupo Biología química de mecanismos regulatorios @biondi_lab

[Biondi Lab @biondi_lab]

After 7 great years in our lab, @marusacer continues her academic formation in the @MRC_LMS in London, as a #PostDoc in the Meiosis Research Group of Enrique Martinez-Pérez. We will miss you a lot and wish you all the best in your new projects and science adventures! 🔬👏

[Mariana Sacerdoti @marusacer]

Farewell dinner with @biondi_lab
Saying goodbye to my team for the last 7 years 🥲! The best scientist AND people

[Biondi Lab @biondi_lab]

We have a new #PhD in the group! @lissy_gross defended her thesis on chemical biology and structural studies of PDK1 conformational regulation, and became a Doctor in Biochemistry from
@UBAonline. Her thesis work was directed by Dr. Biondi and @sebaklinke . Congratulations 🎉

[Instituto de Investigación en Biomedicina de BsAs @IBioBA_MPSP]

La familia del IBioBA tiene una nueva doctora, ¡Felicitaciones @lissy_gross!
🥳👏👏👏🥂
@FFyB_UBA @biondi_lab

[Florencia Herbstein @flor_herbstein]

This is how we celebrate a succesful PhD defense in Argentina 🇦🇷⚽️🏆😂. Congratulations to my dearest friend Dr. @lissy_gross after so many years of sharing our undergrad biochemistry studies and being neighbors at IBioBA. Wishing you all the best in your next scientific steps!

[Biondi Lab @biondi_lab]

Great meeting organized by @SAIB_Argentina! @maca_AMcc and @facugalce assisted with Dr. Biondi and presented posters on our latest work. And congratulations to Facundo and @lissy_gross for being selected as the best poster of the #SignalTransduction area! 👏

[Instituto de Investigación en Biomedicina de BsAs @IBioBA_MPSP]

👉Estuvimos en el Congreso anual de @SAIB_Argentina
✅Facu y Mica presentaron los avances de sus trabajos en formato póster 
✅Ricardo Biondi moderó una charla sobre cáncer
🎖Además, el póster que hicieron @facugalce y Lissy Gross, estuvo entre las menciones ganadoras
¡Bravo!👏

[Biondi Lab @biondi_lab]

Last week we participated of the #FrontiersInBioscience4 symposium! Great meeting organized by @IBioBA_MPSP with top conferences from distinguished scientists from both Argentina and Germany. @maca_AMcc @marusacer @lissy_gross @facugalce

[Instituto de Investigación en Biomedicina de BsAs @IBioBA_MPSP]

¡Seguimos festejando! 🎉
Mariana Sacerdoti @marusacer defendió su tesis sobre la modulación de PDK1, que realizó con la dirección de Ricardo Biondi y la co-dirección de Alejandro Leroux (@aleleroux1) y se recibió de Doctora en Bioquímica 👩‍🔬
¡Felicitaciones, Maru! 👏👏👏

[Biondi Lab @biondi_lab]

We have a new #PhD in the group! 🥳@marusacer
defended last Thursday her thesis on the modulation of the conformational landscape of PDK1 and became a Doctor in #Biochemistry from the University of Buenos Aires. Congratulations Mariana!!
@IBioBA_MPSP @FFyB_UBA

[Iberoamerican ICSA @Ibero_ICSA]

📢 Calling all senescence researchers! Join us for the 1st online meeting of the Iberoamerican Senescence Network. Introduce your research, connect with peers, and prepare for the @ICSA_senescence meeting in Chile. 🗓️Nov 30th. Interested? Email us to 📧[email protected]

[Lissy Gross @lissy_gross]

Thrilled to have witnessed part of the process towards the creation of the first platform for single-particle #CryoEM in Argentina. As users of this network, in @biondi_lab we are really excited to see how #StructuralBiology in LatinAmerica is growing stronger and more connected!

[Biondi Lab @biondi_lab]

5/5 This journey to understand the conformational landscape of full-length #kinase PDK1 was possible thanks to our lab members @marusacer @lissy_gross @aleleroux1, as well as all our amazing collaborators from Arg🇦🇷 and around the globe @piitU @bpfusionjazz @sebaklinke @SaxsTeam

[Biondi Lab @biondi_lab]

1/5 Our latest #ScienceSignaling paper is now available to download for free! It can be found in our institutional webpage from @IBioBA_MPSP under the section "Publications": https://t.co/tMkTup0KLb
A short summary of it in this thread👇🧵

[Biondi Lab @biondi_lab]

4/5 Given the relevance of PDK1 to activate #kinases that promote cell-growth and survival, these results provide new strategies to manipulate PDK1 in future #oncology treatments.