Anne M L

[Anne M L @birding45]

Well, here’s 68 and such a life I have had..thus far… a daughter to Helen & Pete; sister to one sister, 5 brothers 🙄🤣 , a mother to a wonderful son ♥️ twicewife ♥️♥️♥️ And a nurse of many types; w/ dear friends, cycling 🚴🏼‍♀️ & 🥬 gardening…SO BLESSED!!

[Seth Abramson @SethAbramson]

Meanwhile, the photograph below is what the D.C. Reflecting Pool you paid a friend of Donald Trump's $20 million to clean—*16 times* what Trump originally promised—looks like today: filled with algae, more disgusting than ever before.

This man is a *blight* on the United States.

[Seth Abramson @SethAbramson]

BREAKING: NYT Confirms Trump Is Supervising Kennedy Center Tarp Removal As His Agents Appear to Be Indicating It May Stay Up Indefinitely—Effectively Taking *Kennedy's* Name Off the Center As Well As Trump's in One of the Most Petty and Vindictive Acts Ever Taken By Any President

[Bill Madden @maddenifico]

Everything Trump touches turns to shit: Because conman Trump awarded a $14.2 million taxpayer-funded no bid contract to an incompetent friend to makeover the Lincoln Memorial Reflecting Pool, the water is now a putrid smelly swamp of stinking algae.

[Harry Spoelstra @HarrySpoelstra]

Immunothrombosis in hospitalized COVID-19 patients identified by multiomics profiling and linked to postacute complications

🚨INTERESTING New Latvian/Swedish multi-omics study shows immunothrombosis never fully switched off in longC0VID patients: 3 months after COVID hospitalization, your blood is still biologically “clot-ready.”

➡️What makes this study so important:
1. It reinforces that immunothrombosis (the interplay of complement, NETs, and platelets) is a central driver in severe acute COVID-19 and can persist in longC0VID,
2. It confirms persistent endothelial Dysfunction/Endotheliopathy in longC0VID patients, consistent with earlier studies on vascular damage and microclots,
3. It aligns with prior evidence of mitochondrial dysfunction during the acute phase, followed by partial repair mechanisms,
4. The persistent complement activation they observed fits with other recent multi-omics studies showing ongoing complement dysregulation in longC0VID.

➡️Study:
1. Prospective longitudinal multi-omics study of 81 hospitalized COVID-19 patients tracked whole-blood transcriptomics, urine metabolomics (46 analytes), and 13 kidney-injury biomarkers at acute admission, ~1 month, and ~3 months post-hospitalization,

2. Patients stratified by EHR into recovered (n=35) versus long COVID (n=46) groups based on a PASC diagnoses within 12 months,

3. None of the 81 hospitalized patients were vaccinated,

4. Acute phase dominated by interconnected immunothrombosis: strong upregulation of complement (C1QA/B/C), NETosis (PADI4, MPO), and platelet-activation genes (ITGA2B, ITGB3), plus mitochondrial dysfunction (HIF1A/EPAS1 up, OXPHOS down, Warburg-like glycolysis) and elevated renal injury markers (KIM-1 etc.),

5. Most immune, mitochondrial, and metabolomic changes largely normalized by 1–3 months, with rebound in mitophagy/heme genes (PINK1, OPA1, FECH) indicating repair,

6. At 3 months, longC0VID patients showed a distinct transcriptional signature of persistent endothelial activation (↑VWF, PROS1, ITGA2B/ITGB3), complement dysregulation (CFH), and low-grade vascular inflammation/platelet reactivity (CXCL5, ALOX12) that was absent in recovered individuals,

7. No significant late differences in urine metabolomics or kidney biomarkers between groups.

➡️They conclude with their Highlight-points:
• Severe COVID-19 induces immunothrombosis-associated molecular programs,
• Acute COVID-19 is associated with mitochondrial metabolic dysregulation,
• Urine profiling indicates gradual renal recovery after hospitalization,
• LongC0VID patients retain endothelial-associated activation signatures.

‼️So, even after apparent clinical recovery, immunothrombosis leaves a persistent molecular scar of endothelial activation and prothrombotic signalling in longC0VID patients at three months, revealing that the acute vascular battlefield never fully quiets in those who remain symptomatic.

→Three months post Covid-19, longC0VID patient’s blood is still biologically primed to clot!
#AvoidSars2 #AvoidReinfections
https://t.co/PQWLlgx8kp

[Hannah Davis @ahandvanish]

The choroid plexus is a network of specialized cells & blood vessels in the brain that produces cerebrospinal fluid (CSF), filters out toxins, & provides nutrients to the central nervous system.

Recovered COVID patients also had lower cerebral blood flow compared to controls. 2/

[Hannah Davis @ahandvanish]

New: #LongCovid patients have alterations to the choroid plexus and reduced cerebral blood flow.

The alterations were associated with Alzheimer's markers, including GFAP and p-tau217.

https://t.co/qv9klVg7kI 1/

[S Blitshteyn MD, FAAN, FANA, Dysautonomia Clinic @dysclinic]

🫀🧠 When I see new studies and papers coming out on #POTS and #dysautonomia in scientific literature, I am so glad to see this progress! I remember a time when it was one or two papers per month, but now new papers are coming out almost daily! There is a huge need to advance the field: the more, the better!
🦠 Here is a new study (not yet peer-reviewed) that demonstrates impaired immune response in patients with post-COVID POTS, compared to people who recovered from COVID-19, in the form of increased T cell monocytes and proinflammatory cytokines.
📢 My take on this: This study should be replicated in people with POTS unrelated to COVID-19.
https://t.co/mDKs2HoMx9

[Melissa Bime @Melissabime]

the overlap is the problem with reading this as a Parkinson's signal. loss of smell, fatigue, brain fog, dizziness from blood-pressure swings, low mood, those are also just the standard long COVID symptom list. so a higher rate of them in long COVID patients might only be telling you they have long COVID.

the one feature there that actually points at early Parkinson's is dream-enactment, where people physically act out their dreams in their sleep. it is called REM sleep behavior disorder, and it has the strongest track record of any early sign for converting to Parkinson's or Lewy body disease years down the line.

it is also the one you can watch continuously. movement sensors and at-home actigraphy can flag it over months, which makes it the signal worth following over time instead of the rest of the list measured once.

[Vipin M. Vashishtha @vipintukur]

Could #LongCOVID be leaving behind early fingerprints of Parkinson’s disease?

➡️ In a 16-country study of >11,000 participants, people with LongCOVID showed significantly higher rates of multiple prodromal Parkinson’s-like features—including loss of smell, constipation, daytime sleepiness, dizziness, cognitive problems, urinary symptoms, depression, and dream-enactment behaviors. 1/

[Denis - The COVID info guy - @BigBadDenis]

Researchers say there's a big difference between people who think they’ve never had COVID and those who truly haven't. Data suggest only 2–3% of people worldwide may have avoided infection, with many unnoticed cases due to mild or asymptomatic illness.

https://t.co/KUh89qKETh

[Denis - The COVID info guy - @BigBadDenis]

Study: SARS-CoV-2 infection heightens the risk of developing HPV-related carcinoma in situ and cancer.

Published: 14 August 2025

https://t.co/vXSw5hNXfV

[Denis - The COVID info guy - @BigBadDenis]

"Could COVID Increase Your Risk for HPV-Related Cancers?"

A study of 4.8 million women found contracting COVID in 2020 was linked to a higher risk of HPV-driven cancers 3 years later, showing higher cervical, anal, and vulvar cancer rates across all ages.
https://t.co/Y4HNkRfYgK

[Aaron Rupar @atrupar]

Rubio tosses RFK Jr under the bus on vaccines: "The State Dept made the decision that we are going to reengage ... we have certainly allowed Sec. Kennedy to play a leading role, but right now we're at a stage where we are going to reengage."

[Vipin M. Vashishtha @vipintukur]

A new study sheds light on how SARS-CoV-2 may cause loss of smell (anosmia), one of the most common neurological symptoms of COVID-19.

➡️ Researchers found that the virus can directly infect olfactory sensory neurons and trigger abnormal activation of the TRPV1 receptor, leading to damage and degeneration of the nerve fibers responsible for smell. 1/

[Dr. Gee @askgodswill]

What makes these #ASCO26 curves so striking is the mechanism shift. Daraxonrasib targets KRAS G12D — the mutation driving ~40% of pancreatic cancers that was considered undruggable for decades. And the melanoma neoantigen mRNA vaccine trains T-cells against the patient's own tumor fingerprint. Both are attacking root biology rather than just slowing proliferation. Long overdue. 🙏

[Kyle Dempsey @kyleedempsey3]

@EricTopol @ASCO Also worth mentioning the metastatic brain cancer curves from this phase III study— the magnitude of OS improvement is unprecedented, and it’s been >20 years since any study has shown as OS benefit!

[garden bev @gardenbev]

@EricTopol @ASCO As a retired pathologist, I have been musing that we've made great progress against the cancers that kill you fast and hard, but not so much the more common ones that kill you long and slow (but kill you regardless if they are given the chance.)

[Denise @DuhTroof]

@EricTopol @ASCO My friend’s stage 4 melanoma was finally beaten by an experimental treatment that didn’t exist when she was first diagnosed. This is all amazing news!

[Codieverse @ClaudesyI81047]

been staring at these curves for a minute. the top two panels especially, that widening gap at the tail end is the kind of thing you barely dare to hope for in these cancers. it means the benefit isn't just statistical, it's durable. patients who respond keep responding.

also quietly huge: TIGIT working after everyone wrote it off, and mRNA finally delivering in a solid tumor. prostate cancer of all places. nobody had that on their bingo card five years ago.

congrats to everyone who ran these trials. the kind of work that doesn't make headlines until it makes history.

[Eric Topol @EricTopol]

Big progress vs cancer, folks.
The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done. #ASCO26, @ASCO