Delve into the practical applications of realistic medicine by addressing community challenges and advancements in wound care on a global scale. Join our Podiatric Medicine Conference to find out more including disparities in foot care. Book at: https://t.co/1iS6QzfpY5
@3uan
Many think osteoarthritis (OA) is a 'wear and tear' problem.
While the instigator may be traumatic (think ACL injury), framing it as wear-and-tear can cause patients to think exercise will make things worse.
So understanding why cartilage loves load is important...🧵👇 1/7
Role of Mechanical Loading in Managing Tendinopathy
Recent insights from Stańczak et al. (2024) have highlighted the pivotal role of mechanical loading in tendon health and its implications for managing tendinopathy, a condition that accounts for approximately 20% of musculoskeletal complaints:
🔹 Adaptation Through Load: Tendons dynamically respond to various loads (tension, compression, shear), with mechanical stress driving the synthesis of key proteins like Type I collagen and proteoglycans, essential for maintaining tensile strength and hydration.
🔹 Mechano-transduction at Work: Integrins and focal adhesion complexes translate mechanical stimuli into cellular responses, activating pathways such as MAPK/ERK and PI3K/Akt, which regulate extracellular matrix (ECM) remodelling and gene expression.
🔹 Preventing Degeneration: Reduced or improper loading disrupts this balance, leading to ECM disorganisation, inflammation, and degenerative changes—a common pathway in tendinopathy development.
🔹 Rehabilitation Focus: The research underscores that strategic mechanical loading isn’t just about strength; it’s a molecular cue for tendon repair. Tailored load-specific rehabilitation programmes can enhance collagen synthesis, restore matrix integrity, and prevent the progression of tendinopathy.
Full link:
https://t.co/eChouCnC43
🌟 PhD done!!!! 🥳🎓👣
Delighted. Absolutely delighted! Many thanks to my examiners Associate Professor Joanne Paton from the University of Plymouth and Dr @Gordon_Hendry for a wonderful viva experience. I have thoroughly enjoyed our discussions.
@Kittyhi Thank you so much Claire! And thank you so much for all your help and immense support with my recruitment. It is so greatly appreciated! Hope you and your teams are all well ☺️🌟