Bryan Nathalia

PhD Candidate in Synthetic Biology at the Eindhoven University of Technology (TU/e)

[Anna-Maria Makri-Pistikou @AMakriPistikou]

Stoked that the project I started as soon as I started my PhD with @tfadgreef is finally out on #bioRxiv! 📜
Huge effort. 💪🏼It took a village to raise that baby! 👶 🥰
I came in knowing nothing about synthetic receptors (my background was #microRNAs). Tom’s idea to add a miRNA negative feedback loop to #synNotch -the way nature does it-finally became reality with my amazing co-first authors Bryan Nathalia 🦸 and Tom Meuleman 👨‍🔬.

We built a self-limiting, tunable system where activated synNotch induces its own repressor and autonomously attenuates signaling over time.

Really excited about the bigger picture here: embedding this kind of autonomous control has the potential to make engineered cells more predictable, tunable, and adaptive — exactly what we’ll need for safer, smarter cell therapies.

Huge thanks to Bryan, Tom, and the whole team at TU/e, Utrecht University & MIT.

Preprint 👉 https://t.co/9jjHh6dUfL

#SyntheticBiology #CellEngineering #synNotch

[Tom de Greef @tfadgreef]

Excited to share our preprint on autonomous feedback control in synthetic receptor systems.
We engineered a miRNA-based negative feedback circuit where synNotch activation drives expression of a synthetic miRNA that represses the receptor itself.
Preprint: https://t.co/JIEP59vjjb

[Ross Cloney @rosscloney]

Engineering a scalable and orthogonal platform for synthetic communication in mammalian cells @AMakriPistikou @bl_nathalia98 @tfadgreef & co

#BiotechNatureComms

https://t.co/aoV8MJ7ssr

[Tom de Greef @tfadgreef]

Proud to share our latest work on engineering a platform for scalable synthetic communication in mammalian cells. Great work by first author @AMakriPistikou and collaborations with, among others, @MerkxMaarten, @rjerala and many more! @NatureComms
https://t.co/WIQw0wdREv