Rysh

geneticist interested in diversity

[Rysh @bloglablog]

@mindofjada The golden rule?

[Rysh @bloglablog]

I remember seeing a talk about this. The speaker called people with this trait super sleepers! Interesting that they developed a drug that might mimic that trait. I might look into this more later.

[Max Marchione @maxmarchione]

There are people who genetically need only 4-6 hours of sleep per night.

Researchers describe them as energetic, upbeat, resilient, and hard to keep still. Many appear to have type A personalities.

This trait has been associated with rare mutations in five genes: DEC2, ADRB1, NPSR1, GRM1, and SIK3.

Now consider this.

We spend about a third of our lives asleep. Take an 80-year life at 8 hours per night. That’s roughly 27 years spent sleeping. Now imagine a drug that cuts the requirement to 4 hours instead of 8, safely, without sacrificing health, mood, or lifespan.

From age 20 to 80, you would buy back a decade of waking life.

Knowing that Eli Lilly purchased Centessa Pharmaceuticals for $6.3B and its orexin drug pipeline, I think Lilly may be betting on something much broader than narcolepsy.

I believe they're betting on democratizing short sleep.

We have the closest thing to a human existence proof, and it’s not crazy to think we’ll eventually have an “Ozempic for sleep.”

[Rysh @bloglablog]

Yes, there's a clear mechanistic relationship between father's age and risk towards autism/intellectual disability/etc.

[Daisy @DaizyZeeX]

If a man becomes a father at 30, the baby will have 50% more paternal mutations than if he had done it at 18...

[Rysh @bloglablog]

@afederation I'm interested

[Rysh @bloglablog]

To be clear, Jung’s collective unconscious is the idea that all of us humans are biologically hardwired to associate some symbols with certain meanings. Not unlike how we’re hardwired to be afraid of snakes.

[Rysh @bloglablog]

Dragons represent the great, formidable foe that hordes wealth. If we take Jung’s collective unconscious into consideration: Are lizard men the modern manifestation of the dragon mythos?

[Rysh @bloglablog]

However, this evidence also doesn’t rule the possibility out. Dogs may have evolved to evolve faster.

[Rysh @bloglablog]

I’m interested in the evolution of evolvability. Things evolve faster if there is more existing genetic variation to begin with, or if new genetic variation is added quickly through mutations.

[Rysh @bloglablog]

This evidence isn’t conclusive however. Dogs may have a higher rate of SINE and CNV accumulation than wolves due to relaxed purifying selection. https://t.co/YgpxMCwuFY

[Rysh @bloglablog]

https://t.co/yemI5mskhl

[Rysh @bloglablog]

Meridian McDonald proposes a fascinating hypothesis for the increase in autism prevalence in the population. She suggests that it may, in part, be due to an increase in assortative mating over the last century.