Zhe Li

postdoc @UWproteindesign working on designing self-assembled materials from DNA/protein

[Indrek Kalvet @ikalvet]

We are happy to introduce to the world a new family of de novo designed heme enzymes!
This work is the result of a wonderful collaboration between @UWproteindesign and @GreenGroupMIB ! (1/n)
https://t.co/IZM8Qnhvm9

[Cole DeForest @coledeforest]

PUMPED that our paper introducing Light-Activated SpyLigation (#LASL) is now live at @NatureChemistry! We show bioactive proteins can be stably photo-assembled from split fragment pairs in solution, in biomaterials, and in living mammalian cells.

https://t.co/or5UgYMEbc
(1/13)

[Alena Khmelinskaia @khmelinskaia]

Happy to see this work with John and many many many other great collaborators now published in PNAS! (:

[Shunzhi Wang @wang_shunzhi]

Happy to share our recent breakthrough in computational design of 3D protein crystals. We develop a hierarchical approach to target crystal packing with design three orthogonal PPI interfaces, genetically encoded in their primary sequence, a priori. 1/3 https://t.co/NXoHQVn3mL

[Zhe Li @bluelz18]

Thanks @wang_shunzhi, @unattermann, and many others for this great collaboration, with support from the entire IPD under the supervision of Prof. David Baker.

[Zhe Li @bluelz18]

Excited to share our recent breakthrough in designing protein crystallization. We developed a general approach for designing protein self-assembly into 3D macroscopic crystals (>100 µm) at atomic accuracy. Preprint here: https://t.co/IKTwTfZ1hQ. (1/2)

[Zhe Li @bluelz18]

Designed protein crystals have high solvent content with tunable porosity, survive autoclaving, assemble in crude cell lysate, and can scaffold superlattices of inorganic nanoparticles. These emergent properties make them a powerful platform for biological material engineering.

[Shunzhi Wang @wang_shunzhi]

Excited to share our work on "top-down" reinforcement learning based approach to design proteins with exquisite structural control. The Monte Carlo tree search algorithm generate protein monomers and assemblies, guided by input geometric constraints. 1/4 https://t.co/OQvRqXSEbF

[Zhe Li @bluelz18]

@AjasjaLjubetic Wow! Sounds like a good number for two rounds of centrifugation.

[Zhe Li @bluelz18]

The article is like a memo of all the little excitements that I had when playing around with those crystals.