Cole DeForest

Weyerhaeuser Associate Professor of Chemical Engineering & Bioengineering, University of Washington | Husband | Father | Outdoor Enthusiast

[Cole DeForest @coledeforest]

HUGE NEWS! In our new preprint, we introduce “grayscale image z-stack-guided multiphoton optical-lithography” (GIZMO) to rapidly photomodulate materials in full 3D non-binary patterns at sub-µm resolutions spanning large volumes (>mm3).

https://t.co/5QJmZDschS

Paper 🧵 (1/19)

[bioRxiv @biorxivpreprint]

Grayscale 4D Biomaterial Customization at High Resolution and Scale https://t.co/SnamjMqcUn #bioRxiv

[Cole DeForest @coledeforest]

Check out our lab's new manuscript entitled "Boolean Logic-Based Control Over Recombinant Protein Biomaterial Degradability and Therapeutic Delivery", now live in Advanced Materials (@AdvPortfolio)!

🔓: https://t.co/VACUfEwYh9

Huge congrats to Murial, Ryan, and Shivani!

[Cole DeForest @coledeforest]

The publishing streak continues! Excited to share our new article in Nature Reviews Materials @NatRevMater entitled "Engineering Complexity into Protein-based Biomaterials for Biomedical Applications"!

Check it out here:
📜: https://t.co/bg88EmWjb9
🔓: https://t.co/xZ36hPqS14

[Cole DeForest @coledeforest]

Check out our new paper entitled "Boolean Logic-based Controlled Release of Bioactive Proteins with Diversified Inputs", live in @angew_chem!

Growth factors, enzymes, nanobodies, cytokines, and fluorescent proteins can now be "logically" delivered!

📜: https://t.co/0ECwq8V8mR

[UW News @uwnews]

Medicine isn’t just about finding the right therapies — it’s also about getting them to where in the body they’re needed. These new smart proteins can autonomously read bodily cues to zero in on the exact locations of diseases. @coledeforest
https://t.co/qANwLDrPLL

[Cole DeForest @coledeforest]

Our latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (@CellBiomat, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"!

🔓 : https://t.co/GSSJPePbgX

[Cole DeForest @coledeforest]

Our new paper entitled “Boolean Logic-gated Protein Presentation through Autonomously Compiled Molecular Topology” is now live at Nature Chemical Biology! Check it out!

📜: https://t.co/apDvC2TG7V

Thanks to @uwnews for the feature write-up! https://t.co/3tDUmuepDD

[Cole DeForest @coledeforest]

Thanks also to @UWISCRM for nicely highlighting the work!

https://t.co/n2BjNAkfXB

[Cole DeForest @coledeforest]

New in @ScienceMagazine, we report that dilated cardiomyopathy can be alleviated by preventing hypocontractility-induced fibroblast expansion! The story is a fun combination of advanced in vivo and biomaterial-based in vitro models. Check it out!

📜 : https://t.co/FHYmZH6azq

[Cole DeForest @coledeforest]

Mike Regnier, Farid Moussavi-Harami, Nate Sniadecki, and their respective labs also played instrumental roles on these exciting efforts!

[Cole DeForest @coledeforest]

Our new manuscript entitled "PhoCoil: A Photodegradable and Injectable Single-component Recombinant Protein Hydrogel for Minimally Invasive Delivery and Degradation" is now live at @ScienceAdvances!

Check it out here (🔓): https://t.co/kZmXa1C6ZS

[ISCRM at UW @UWISCRM]

A new study in @ScienceAdvances from @coledeforest introduces PhoCoil, a recombinant protein hydrogel with light-triggered disassembly, enabling precise spatiotemporal control of cell delivery, advancing tools for regenerative medicine + cell therapy.
https://t.co/WmUzWAiBlS

[Cole DeForest @coledeforest]

Check out our new paper entitled "Genetically Encoded Interpenetrating Polymer Networks as Injectable Biomaterials for Controlled Therapeutic Protein Delivery", appearing in @ACSBiomaterials!

https://t.co/YA1fgRtD0e

[Cole DeForest @coledeforest]

@jkmontclare @UW Thanks for visiting us in @UWChemE and for the fantastic seminar! Great to learn about all of the exciting new efforts in your lab!

[Cole DeForest @coledeforest]

@andrea_j0seph @SyracuseU @SyracuseBmce @SUBioInspired @profnance @JHU_ChemBE @UWChemE @CRSScience @SRIWomensHealth Congrats, @andrea_j0seph ! Excited to see what comes from your lab in the coming years!

[Cole DeForest @coledeforest]

@gingerlabUW @UW @UW_CEI @WagnerCustom Amazing! Would love to see them out on the snow sometime!

[Cole DeForest @coledeforest]

Happy Holidays from the DeForest Lab!

What fun to celebrate the group’s 2024 achievements, especially in the baking sector. Our annual dessert bake-off competition was a tasty success!

[Cole DeForest @coledeforest]

Professors often tell graduate students that “Your PhD is a #marathon, not a sprint”.

Having now run the 2024 @SeattleMarathon (many years after finishing a PhD), I now actually feel qualified to make such a statement.

@UWMedicine

[Cole DeForest @coledeforest]

@joelfinbloom @AmaniHariri20 @SMitragotri @cryoem_UBC @ubcpharmacy Thanks for the invitation, @joelfinbloom ! It was great to share a bit of our work and to learn about all of the exciting nanomedicine research taking place in Vancouver and beyond!

[Cole DeForest @coledeforest]

Happy Halloween! 👻

A patterned arrangement of photos, each of an analytical balance/scale that is colored gray?

Or, perhaps... a "grayscale photopattern"?

(costume inspired by our lab's recent work here: https://t.co/5QJmZDschS)

[Cole DeForest @coledeforest]

Come be our new faculty colleague - we're hiring this year at @UWBioE! Great department, stupendous science, awesome location, and amazing people!

[Kelly Stevens @kellystevenslab]

Calling all faculty candidates (postdocs, Asst Profs, senior grad students) - Apply to @UWBioE! Job ad at link below. If you are considering applying and have questions on the ad, please email or DM me. Come join us, UW is amazing! https://t.co/SaWp9k7nsD