Just published today from Yibin Kang & co: TGF-b-induced Dact1 forms biomolecular condensates that sequester CK2 to repress Wnt signalling and modulate bone metastasis.
Read the full manuscript here: https://t.co/UsS4RUlJ0h
https://t.co/7zaqOAsx5B
Cool condensate work with the Tomocube done here in #PrincetonMOLBIO TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis | Nature Cell Biology https://t.co/1bXpRqQ4U5
@peiferlabunc We were inspired by your work to dig into phase separation and Wnt regulation. New paper out on Dact1 condensates that might be of interest: https://t.co/WiQMSOlQUu
@Princeton researchers Mark Esposito and Yibin Kang identify a new organelle driven by phase separation that drives #cancer metastasis. https://t.co/WiQMSOlQUu
Princeton’s leading cancer researchers, including Yibin Kang, were startled to discover that what they thought was a straightforward investigation into how cancer spreads through the body turned up evidence of liquid-liquid phase separations.
https://t.co/ie5JJAjIAC
Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis [$] https://t.co/9dr0IrgxLn #cancerSC via @zangaridelbalzo
New findings in @NatureCellBio provide unique insights into the functional role of E-selectin as a component of the vascular niche critical for metastatic colonization in bone. https://t.co/BgCWJ9LMsv @PrincetonMolBio
Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. https://t.co/4h0WDgt13Q
A team of researchers led by #PrincetonU and supported by @RutgersCancer has discovered a factor that promotes the spread of cancers to bone, opening the way toward treatments that could mitigate cancer’s ability to colonize bone. https://t.co/GrAR9KYHw7
Excited to contribute to the understanding of how breast cancer spreads to the bone! New paper out in NCB https://t.co/RfEKGDOiD8 #cancer#cancerresearch