BrianWalcottMD

cerebrovascular neurosurgeon - specializing in aneurysm, AVM, stroke, moyamoya, and more

[BrianWalcottMD @brianwalcottmd]

A peptide vaccine trial to prevent pancreatic cancer - it teaches your own immune system to fight off the mutated protein. This is part of a broader push toward primary prevention vaccines for people who carry inherited cancer risk. For BRCA1 and BRCA2, the Basser Center at Penn Medicine is running interception vaccine trials in healthy carriers, and Cleveland Clinic is testing a vaccine in BRCA1 and PALB2 carriers planning risk-reducing mastectomy. For Lynch syndrome, the NOUS-209 neoantigen vaccine showed immune responses in carriers in a phase 1b/2 trial published in Nature Medicine this year and has FDA Fast Track designation, with the PROTECT-Lynch phase 3 and the Tri-Ad5 program also moving forward. If you carry a pathogenic variant in BRCA1, BRCA2, a Lynch syndrome gene, or another heritable cancer condition, ask your genetics team or oncologist whether a prevention trial fits your situation. Remember, I’m a doctor, just not your doctor 🩺

Cancer Discovery, July 16 2026. DOI 10.1158/2159-8290.CD-25-2245. Trial NCT05013216, still enrolling

[BrianWalcottMD @brianwalcottmd]

@PedroFounder good tech

[BrianWalcottMD @brianwalcottmd]

@tickerisNUTS so basically hold $NUTS?

[BrianWalcottMD @brianwalcottmd]

@anonchain proceed

[BrianWalcottMD @brianwalcottmd]

@artthatfucks @tickerisNUTS tingles = good

[BrianWalcottMD @brianwalcottmd]

@anonchain @wetpotatobrain iykyk!

[BrianWalcottMD @brianwalcottmd]

@grok @wetpotatobrain How does it compare to other long form generative projects from different artists? Think @artblocks_io 2021 era, as well as more contemporary works.

[BrianWalcottMD @brianwalcottmd]

@mcuban We all know this will just lead to FURTHER Medicare “efficiency adjustments” to reimbursement 😭

[BrianWalcottMD @brianwalcottmd]

@GuidoDisalle @wetpotatobrain Very nice looking Fiducial Markers 🫡

[BrianWalcottMD @brianwalcottmd]

@vitorborin_ @AnilMakam Tough but fair

[BrianWalcottMD @brianwalcottmd]

@CoffeeBlackMD Tough but fair

[BrianWalcottMD @brianwalcottmd]

Real medical screening is about one thing: finding disease early enough to actually change your future. Effective screening focuses on diseases where early treatment can improve outcomes or can cure. Think of things like colonoscopies, mammograms, or low dose chest CTs for smokers.

Commercial screening usually uncovers normal things, abnormal things that are harmless, or disease where treatment cannot cure. These things are not helpful. They lead to endless secondary testing, severe anxiety, and sometimes unnecessary surgeries, all without improving survival.

This is exactly why no major medical society recommends routine whole body MRI screening for healthy, asymptomatic adults. Preventive medicine saves lives. Commercialized wellness scans are magical thinking at best and an upper level financial grift at worst (likely both).

Talk to a real doctor about your health, not a podcaster.

#EvidenceBasedMedicine #NeurosurgeryAwarenessMonth #PreventiveMedicine #WholeBodyMRI

[BrianWalcottMD @brianwalcottmd]

@grok Under US law, what is retatrutide’s exact regulatory status right now, and is there any lawful pathway for a patient to obtain it outside a clinical trial? Address specifically: 1. its FDA approval status and where it sits in Lilly’s development program, 2. whether it qualifies for compounding under FDCA 503A or 503B, walking through each eligibility criterion (component of an approved drug, USP/NF monograph, presence on FDA’s bulk drug substances lists), 3. what that means for any product currently being sold or administered as retatrutide in the USA from both patient and physician standpoint, and (4) what FDA enforcement activity has occurred against retatrutide vendors, including the number of warning letters issued and the date range. Be blunt about the legal conclusion rather than hedging.

[BrianWalcottMD @brianwalcottmd]

Things that never happened for 500, Alex

[Andrew D. Huberman, Ph.D. @hubermanlab]

The whole body MRI thing is controversial for obvious reasons. It’s costly & there are a lot of false positives. But I have neurosurgeon friends who tell me they do life-saving surgeries *every month* b/c people got full body MRI merely b/c they curious & found operable issues.

[BrianWalcottMD @brianwalcottmd]

@noahkaufmanmd Per patient metric (hypothesized) this non-profit hospital ceo probably wins by a landslide https://t.co/0JYVil7Orh

[BrianWalcottMD @brianwalcottmd]

@ferrisbuhler81 @ways2wellX Do you believe in magic ?🪄

[BrianWalcottMD @brianwalcottmd]

@YannickBuccella

[BrianWalcottMD @brianwalcottmd]

@nickmmark why are there so few likes and bookmarks? im genuninely confused by this

[BrianWalcottMD @brianwalcottmd]

The road to becoming a doctor is long and difficult. A lot of personal sacrifices are made along the way. In the end, you learn a lot about yourself, and medicine! Many people can call themselves doctor and act like one on social media, but you owe it to yourself to find out who you are really listening to 🩺