Geneticist turned Drug hunter • Chief Scientific Officer @Enveda • I dig hard problems & great adventures • Airplanes • One lucky human • Tweets my own
What can AI tell us about #nature and #chemistry? What can the 𝗽𝗮𝘀𝘁 reveal about what’s possible 𝙩𝙤𝙢𝙤𝙧𝙧𝙤𝙬?
At #WEF26 𝗶𝗻 𝗗𝗮𝘃𝗼𝘀, we had the opportunity to share a different view of #AI’s role in the world. Not just as a tool to make things faster or cheaper—but as a way to fundamentally change how we understand life itself.
At 𝗘𝗻𝘃𝗲𝗱𝗮, we’re using AI to read nature’s chemistry at scale, learning from billions of years of evolution to uncover new medicines that were previously invisible to us. This isn’t about replacing biology. It’s about finally being able to understand it through chemistry.
Grateful to the World Economic Forum for convening conversations that look beyond optimization—and toward reinvention.
#JPM26 was the best yet for Enveda - presenting at a packed house at the conference, where we discussed our incredible 𝗣𝗵𝗮𝘀𝗲 𝟭𝗯 𝗿𝗲𝘀𝘂𝗹𝘁𝘀 𝗶𝗻 𝗮𝘁𝗼𝗽𝗶𝗰 𝗱𝗲𝗿𝗺𝗮𝘁𝗶𝘁𝗶𝘀, and building a 𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗯𝗶𝗼𝘁𝗲𝗰𝗵.
We've been working hard behind the scenes to get us to where we are today, with 𝟰 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗽𝗿𝗼𝗴𝗿𝗮𝗺𝘀 𝗶𝗻 𝗷𝘂𝘀𝘁 𝟲 𝘆𝗲𝗮𝗿𝘀 in the largest indications, and we are just getting started.
You might even have caught one of our ads for our 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝘁𝗿𝗶𝗮𝗹𝘀 in 𝗮𝘁𝗼𝗽𝗶𝗰 𝗱𝗲𝗿𝗺𝗮𝘁𝗶𝘁𝗶𝘀 and 𝗼𝗯𝗲𝘀𝗶𝘁𝘆!
Patients need new and differentiated options and can't wait!
Stay tuned!
#JPMHC26
One more thing.
We have received another FDA IND clearance and have initiated Phase 1 for ENV-6946, bringing our total to three first-in-class, novel, nature-inspired molecules in the clinic.
ENV-6946 is an oral small molecule engineered for the potential to treat inflammatory bowel disease, designed as a “multi-biologic in a pill.” It simultaneously targets TNFα, IL-23, and TL1A signaling in the gut without requiring separate injectable therapies.
Millions of people live with IBD, with far too few efficacious, safe, durable, and convenient options available. ENV-6946 represents a new path forward – one designed for efficacy, safety, and simplicity.
With ENV-294, ENV-308, and now ENV-6946 in clinical development, we continue to demonstrate:
• The ingenuity of nature
• The power of our platform
• The pace and commitment of our team
Onward.
Read more: https://t.co/GH04ifkwyb
We are proud to announce our latest milestone at Enveda:
FDA IND clearance and first patient dosed for ENV-308, our first-in-class oral therapy for obesity.
GLP-1s changed expectations for weight loss. But they also raised challenging questions:
Can patients stay on them long term?
What happens after weight loss?
Who can realistically access injectable medicines on a global scale?
ENV-308 is a once-daily oral small molecule designed with exciting potential for durability, tolerability, and real-world use. It’s built for long-term metabolic health, not just short-term weight loss. And it’s designed to fit into everyday life, earlier in care and over years, not months.
Obesity is a chronic disease. Solving it at the population scale will require new tools, new thinking, and medicines designed to last.
This milestone is a first step.
And yes, we are now a multi-asset clinical-stage company!
Read more: https://t.co/EJgeRSsX4U
We are excited to welcome Nadeem Sarwar to Enveda as SVP & Global Head of Disease Prevention and Metabolic Disease Strategy.
Nadeem brings rare experience from the front lines of metabolic medicine, as the former Co-Founder and Head of the Transformational Prevention Unit (TPU) at @novonordisk , where he helped shape the industry's approach to obesity, risk, and long-term health.
At Enveda, we believe the future of medicine is not just treating disease, but ensuring long-term benefit or even preventing it before it takes hold. With our first-in-class oral metabolic program now in the clinic, Nadeem will help unlock the next chapter: medicines designed for durability, scalability, and real-world use.
This isn’t just about doing things differently. It’s about raising the bar for what patients can expect.
We are thrilled to help build a healthier future for society.
Welcome to Enveda, Nadeem.
Read more: https://t.co/EJgeRSsX4U
How we built a unicorn from seed in 5 years…
There are no secrets, but purpose, pace, and an incredible team certainly help.
“We’re combining ancient ancestral wisdom with the power of nature’s chemistry with modern AI and drug discovery,” Colluru said. “We’re standing on the shoulders of maybe the giant, which is Mother Nature.”
Read more by @damiangarde in @business about how we raised our Series D, advanced our lead candidate in atopic dermatitis to Phase 1b, and brought on a pharma legend Mikael Dolsten as we prepare to enter more programs in the clinic this year... and stay tuned for more.
#Unicorn #Startups #AI #DrugDiscovery #Nature
The intersection of biology and AI is powerful.
How do we build for the most meaningful impact? Leaders with vision, candor, and ambition are tackling the hardest questions facing our industry.
@viswacolluru, our founder and CEO, is speaking at the AI x Bio Summit hosted by @decodingbio and the @NYSE this Tuesday, July 21st. This exclusive forum brings together leaders advancing healthcare at the nexus of health, innovation, and the economy.
#AIxBio #DrugDiscovery #Biotech #AI
How do you build an organization to scale a biotech platform into a successful pipeline and beyond?
Hannah Gordon, PhD, MSCI (@brieski), Chief Product Officer at Enveda leads a global team that has scaled platforms and delivered multiple clinical candidates at the forefront of AI and biology.
She will share how we're hiring for what matters at the AI x Bio Summit hosted by @decodingbio and the @NYSE today July 21st. This forum brings together forward-thinking innovators who are shaping the next era of biotech through bold ideas and practical execution.
#AIxBio #Biotech #Talent #Hiring
🚀 We did it again! For the 2nd year in a row, Enveda has been named one of America’s Best Startup Employers – and we’re ranked #2 in biotech! ✨
🔗 https://t.co/xsVmS8yG4t
This recognition is a reflection of the incredible people who make Enveda a bold, mission-driven company where innovation thrives. If you’re ready to do the most impactful work of your career and be part of a once-in-a-generation company that’s transforming the future of medicine, we’d love to meet you.
Come build with us! #hiring #biotech #startup #bestemployers
One signal that you're doing things right is to have your investors continually double down. We are incredibly thankful to have the visionary investors at @premjiinvest extend our relationship. Founded by the legendary businessman Azim Premji, Founder Chairman of @Wipro. They know a thing or two about building amazing companies.
Read more here: https://t.co/hvV07aiPOH
We're proud to announce the formation of our Therapeutic Advisory Board, chaired by Nicholas A. Saccomano Ph.D., which will help guide our expanding pipeline and clinical trials. Read on to learn more 🧵👇
In today’s blog post, @ddomingof lays out the data-driven approach he led to determine where, within the vastness of biodiversity, Enveda should first deploy its new NGS-for-chemistry tool to find new medicines (hint: it’s the oldest source of medicines): https://t.co/If9R8hn4iE
Today on the blog: founder @viswacolluru lays out how re-integrating chemistry into our understanding of cell & organismal biology can complement and extend our genomically-inspired map of biology -- and the tech Enveda is building to make this happen: https://t.co/kCNk1VkE5k
We’re still celebrating our recognition as an @endpts 11 company! To welcome our new followers, starting Thursday we’ll be posting a four-part weekly blog series highlighting the key values of our unique approach to drug discovery (and beyond). And for more on the Endpoints 11: https://t.co/l0eldKdjtC
Second annual #Excursion concert… Former Recursionauts responsible for founding @envedabio, @noetik_ai, @known_med, and @leashlabs. Proud of all of these awesome folks and the impact what they are building will have.
@GregoryJBarber@WIRED I'm framing this line! It's all about velocity and execution. Moving with high conviction and a single-mindedness. Ruthless execution is a superpower that everyone can practice.