AutoAb analysis of 140 systemic sclerosis shows low sensitivity (<33%), high specificity (>88%). Scl-70+ signif assoc w sine scleroderma, digital ulcers, Raynauds as 1st onset sign. SSc-ILD more common Scl-70 and PAH with CENP A/B Abs https://t.co/1zvkte4drJ
2 open-label reports of JAK inhibitors in Systemic sclerosis (SSc) - 59 SSc pts: significant decr in mRSS in 88%. 28/29 w/ ILD had no progression. Overall responses better in treatment naïve SSc patients. 20% had side-effects. More studies needed https://t.co/sR2OMNtxAk
Just accepted in Arthritis & Rheumatology:
Decrease in body mass index is associated with reduced incidence and progression of the structural defects of knee osteoarthritis: a prospective multi-cohort study
https://t.co/Rn5y6MI2Pv
✅ Just a few more days before the start of the European #Lupus Meeting by @SLEuroSociety in Stockholm 🇸🇪 Don't miss my Thursday (6 oct) morning talk about #SLE in men!
Hydroxychloroquine Dosing and SLE Flares
JAMA cohort study examining HCQ dosing in patients with SLE suggests that HCQ doses of 5 mg/kg per day or less, was associated with a higher risk of lupus flares, including moderate or severe lupus flares.
https://t.co/B5HqxWDqD3
Causes of slope is. Nice pictograph. Androgen pattern (mail pattern hair loss), diffuse (telegen effluvium)and local bald spots (alopecia areata). Latter@May be helped w topical or oral JAK inhibitors.
A 61-year-old woman with primary biliary cholangitis and Raynaud’s phenomenon was referred to the rheumatology clinic. Tongue telangiectasias, puffy fingers, and nailfold capillary hemorrhage were present. https://t.co/h6IkCGGWXE
Olokizumab, another IL-6 Inhibitor for RA
This week's NEJM has published the efficacy results of a large phase 3 trial of olokizumab, a humanized monoclonal antibody that directly targets interleukin-6 (IL-6) in patients with rheumatoid arthritis (RA).
https://t.co/VMz8xzffiZ
Hyaluronic Acid Knee Injections Equivalent to Placebo
In the United States, where over $300 million is spent annually on intraarticular hyaluronic acid injections, yet another study shows such therapy to be no better than placebo.
https://t.co/1pSVr3VI4t
✅ What's the difference between EARLY #LUPUS, incomplete #SLE & pre-clinical lupus?
Well, it is whether 🔎 the clinical manifestations of lupus 🦋 are present (or not) and whether the #DIAGNOSIS 🏨 is yet made (or not) ⬇️ timeline below.
#Rheumtwitter#MedTwitter#MedEd
🆕The impact of temporary methotrexate discontinuation for 1 week versus 2 weeks on seasonal influenza vaccination in patients with RA:
💊1 week❌ is non-inferior 2 weeks ❌ after vaccination
Interesting 🤔
https://t.co/bpBGcuF7Pt
Do not take antacids or PPI with mycophenolate. Magnesium & aluminium hydroxide antacids (Maalox) will lower MMF Cmax 33% & AUC 17% if given simultaneously. PPI also lowers AUC by ~33% https://t.co/IoWISgL3SY https://t.co/JV1Yv5Pg9d https://t.co/b8UoQ4zMUV